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Editor’s Choice Articles

Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.

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12 pages, 1103 KB  
Systematic Review
Dental Implant Failure Risk in Patients with Bruxism—A Systematic Review and Meta-Analysis of the Literature
by Josephine A. Ionfrida, Hanna L. Stiller, Peer W. Kämmerer and Christian Walter
Dent. J. 2025, 13(1), 11; https://doi.org/10.3390/dj13010011 - 26 Dec 2024
Cited by 12 | Viewed by 5469
Abstract
Background/Objectives: Recent research has indicated that placing dental implants in patients diagnosed with bruxism has led to higher rates of implant failure. This study aimed to provide more accurate knowledge about the relationship between bruxism and implant loss in patients (number, age, gender) [...] Read more.
Background/Objectives: Recent research has indicated that placing dental implants in patients diagnosed with bruxism has led to higher rates of implant failure. This study aimed to provide more accurate knowledge about the relationship between bruxism and implant loss in patients (number, age, gender) with different numbers of implants and prosthetic restorations, considering the follow-up time, compared to non-bruxers. Methods: A systematic search was conducted in PubMed and Cochrane Library using the keyword combination “dental implant”, “bruxism”, and “implant failure”. This search had no language or time restrictions. Results: The review included 15 papers, which were divided into four groups. The first group focused on studies regarding implant loss regardless of the superstructure. In the second group, research on implant-supported removable prostheses was examined. The third group consisted of a single study specifically addressing implant-supported single crowns. Lastly, the fourth group comprised two studies investigating implant-supported single crowns and fixed partial dentures. Only three out of the fifteen studies failed to find a correlation between bruxism and implant failure. The meta-analysis shows a significant pooled effect across the included studies, with an odds ratio of 4.68. Conclusions: Bruxism is a probable risk factor for mechanical issues in implant-supported prostheses and implant-supported crowns. Additionally, elevated failure rates have been documented in patients with bruxism. Full article
(This article belongs to the Special Issue Risk Factors in Implantology)
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19 pages, 16272 KB  
Article
Predictable Full Digital Workflow Using Stackable Surgical Templates for Complete Dental Arch Rehabilitation with Implant-Supported Fixed Restorations—Case Series and Proof of Concept
by Corina Marilena Cristache, Oana Elena Burlacu Vatamanu, Cristian Corneliu Butnarasu, Tamara Mihut and Eliza Denisa Sgiea
Dent. J. 2024, 12(11), 347; https://doi.org/10.3390/dj12110347 - 30 Oct 2024
Cited by 7 | Viewed by 3383
Abstract
Background: In recent years, advancements in digital dentistry have provided new opportunities for more predictable and efficient treatment options, particularly in patients with failing dentition. This study aimed to evaluate the effectiveness and accuracy of a fully digital workflow using stackable surgical templates [...] Read more.
Background: In recent years, advancements in digital dentistry have provided new opportunities for more predictable and efficient treatment options, particularly in patients with failing dentition. This study aimed to evaluate the effectiveness and accuracy of a fully digital workflow using stackable surgical templates for complete dental arch rehabilitation with implant-supported fixed restorations. Methods: Four patients, comprising two males and two females with a mean age of 66 years, were included in this case series. Each patient underwent meticulous digital planning, including CBCT and intraoral scanning, to create a virtual patient for preoperative assessment and virtual treatment planning. The assessment of the trueness of implant positioning was conducted in Geomagic Control X software (version 2017.0.3) by referencing anatomical landmarks from both the preoperative and one-year postoperative CBCT scans. Results: A total of 25 dental implants were placed in the maxilla, followed by the installation of long-term provisional restorations. The results showed minimal deviation between the planned and actual implant positions, with mean 3D coronal, apical, and angular discrepancies of 0.87 mm, 2.04 mm, and 2.67°, respectively. All implants achieved successful osseointegration, and no failures were recorded, resulting in a 100% survival rate at the one-year follow-up. Patients reported high satisfaction with both the esthetic and functional outcomes based on their subjective feedback. Conclusions: The findings suggest that the use of a fully digital workflow with stackable surgical templates is a reliable and effective approach for immediate implant placement and prosthetic rehabilitation, enhancing treatment precision and patient comfort. Full article
(This article belongs to the Special Issue Advancements and Implications of Digital Workflow Integration in Implant Dentistry)
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14 pages, 778 KB  
Review
Correlation between Periodontitis and Onset of Alzheimer’s Disease: A Literature Review
by Antonio Barbarisi, Valeria Visconti, Dorina Lauritano, Francesca Cremonini, Gianluigi Caccianiga and Saverio Ceraulo
Dent. J. 2024, 12(10), 331; https://doi.org/10.3390/dj12100331 - 17 Oct 2024
Cited by 22 | Viewed by 5679
Abstract
Background: Alzheimer’s disease is a slowly progressing neurodegenerative illness and the most common form of dementia. This pathology leads to an increase in cognitive decline and is responsible, in patients, for several difficulties in performing various activities of daily living, such as oral [...] Read more.
Background: Alzheimer’s disease is a slowly progressing neurodegenerative illness and the most common form of dementia. This pathology leads to an increase in cognitive decline and is responsible, in patients, for several difficulties in performing various activities of daily living, such as oral hygiene. Several experimental studies have shown that oral health in patients with Alzheimer’s disease worsens in direct proportion to the progression of the disease due to the appearance of gingivitis and periodontitis. Methods: This clinical literature review aims to evaluate a possible correlation between periodontal disease and Alzheimer’s disease, trying to understand if the periopathogens can contribute to the onset or the progression of Alzheimer’s disease (AD). The study was conducted on the database PubMed (MEDLINE) of full-text systematic reviews in English on humans and animals that were published in the last five years, from 2018 to 2023. This returned 50 publications, which, once the eligibility criteria were applied, resulted in the 10 publications examined in this review. The selected articles were organized through the construction of tables, analyzed, and compared through Judith Garrard’s Matrix method to arrive at the review results. Results: Infection by periopathogens can increase the risk of developing Alzheimer’s disease, but also the onset of the latter can make it more difficult to maintain proper oral hygiene, favoring the onset of periodontal disease: it is possible to affirm the existence of a correlation between periodontitis and AD. It was found that patients exposed to chronic periodontitis have a greater risk of developing a cognitive decline or AD and that oral pathogens can be responsible for neuropathologies and increasing systemic inflammation. Conclusions: Periodontitis and periodontal pathogens represent a real risk factor for the onset or worsening of AD; however, the pathogenetic mechanism is still not completely clear. Full article
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13 pages, 3919 KB  
Article
Comparative Histological Analysis of Dentine-Derived Tooth Grafts in Maxillary vs Mandibular Socket Preservation: A Retrospective Study of 178 Cases
by Elio Minetti, Francesco Gianfreda, Patrizio Bollero, Ciro Annicchiarico, Monica Daniele, Rossella Padula and Filiberto Mastrangelo
Dent. J. 2024, 12(10), 320; https://doi.org/10.3390/dj12100320 - 7 Oct 2024
Cited by 7 | Viewed by 2689
Abstract
(1) Background: In recent years, there has been a growing interest in tooth-derived materials as valuable alternatives to synthetic biomaterials for preventing alveolar ridge dimensional changes. This study aimed to evaluate the histological and clinical differences between alveolar ridge preservation procedures in the [...] Read more.
(1) Background: In recent years, there has been a growing interest in tooth-derived materials as valuable alternatives to synthetic biomaterials for preventing alveolar ridge dimensional changes. This study aimed to evaluate the histological and clinical differences between alveolar ridge preservation procedures in the maxilla and mandible using demineralized dentin treated with Tooth Transformer®. (2) Methods: A total of 178 patients in good general health were enrolled, with 187 post-extractive sockets lacking buccal and/or palatal bone walls. Alveolar socket preservation procedures and histological evaluations were performed. The sites were divided into two groups: Group A (99 mandibular samples) and Group B (108 maxillary samples). After 5 months (±1 month), single bone biopsies were performed for histologic and histomorphometric analysis. (3) Results: Clinical outcomes demonstrated a good healing of hard and soft tissues with an effective maintenance of bone architecture in both groups. Histomorphometric analysis revealed a total bone volume of 50.33% (±14.86) in Group A compared to 43.53% (±12.73) in Group B. The vital new bone volume was 40.59% (±19.90) in Group A versus 29.70% (±17.68) in Group B, with residual graft dentin material volume at 7.95% (±9.85) in Group A compared to 6.75% (±9.62) in Group B. (4) Conclusions: These results indicate that tooth-derived material supports hard tissue reconstruction by following the structure of the surrounding bone tissue. A 6.8% difference observed between the maxilla and mandible reflects the inherent disparities in natural bone structures in these regions. This suggests that the bone regeneration process after tooth extraction adheres to an anatomical functional pattern that reflects the specific bone characteristics of each area, thus contributing to the preservation of the morphology and functionality of the surrounding bone tissue. Full article
(This article belongs to the Special Issue Dental Materials Design and Innovative Treatment Approach)
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14 pages, 1605 KB  
Article
Characteristics of the Occlusal Plane Associated with Unilateral and Bilateral Articular Eminence Inclination: A Cross-Sectional CBCT Study
by Fátima Erandi Camacho-Álvarez, Silvia Paulina Martínez-Contreras, Jacqueline A. Rodríguez-Chávez, Gerardo Martínez-Suárez, Álvaro Edgar González-Aragón Pineda, Ronald Roossevelt Ramos-Montiel, Carla Monserrat Ramírez-Martínez, Sergio Sánchez-García, Luis Pablo Cruz-Hervert and María Eugenia Jiménez-Corona
Dent. J. 2024, 12(10), 316; https://doi.org/10.3390/dj12100316 - 29 Sep 2024
Cited by 7 | Viewed by 3445
Abstract
The characteristics of the temporomandibular joint (TMJ) are essential in orthodontic and prosthetic treatments. Previous studies have suggested an association between articular eminence inclinations (AEI) and occlusal plane characteristics using radiographs, but no bilateral analysis has been conducted using cone beam computed tomography [...] Read more.
The characteristics of the temporomandibular joint (TMJ) are essential in orthodontic and prosthetic treatments. Previous studies have suggested an association between articular eminence inclinations (AEI) and occlusal plane characteristics using radiographs, but no bilateral analysis has been conducted using cone beam computed tomography (CBCT). Objective: This study aimed to investigate the specific characteristics of the occlusal plane inclinations associated with unilateral and bilateral AEI using CBCT. Methods: We conducted a cross-sectional study to evaluate 200 temporomandibular joints (TMJs) from 100 records obtained at the orthodontic department. We evaluated the association between the AEI, and occlusal plane characteristics like the cant of the occlusal angle, occlusal plane angles, inclination of the upper incisor to the Frankfort plane and palatal plane using both bivariate and multivariate analyses both unilaterally and bilaterally. Results: Our findings suggested statistically significant associations (p < 0.050) between AEI (bilateral) and occlusal inclination parameters, including the cant of the occlusal plane (Coef. −0.38; 95%CI −0.70:−0.06; p = 0.017), occlusal plane angle (Coef. −0.39; 95%CI −0.740:−0.05; p = 0.024), and position of the upper incisor relative to the palatal plane (Coef. −0.34; 95%CI −0.63:−0.06; p = 0.016). Conclusion: This study suggests an association between dental inclinations and AEI, which reflects the anatomical characteristics of TMJ and its related dental structures. Full article
(This article belongs to the Topic Diagnosis and Treatment of Dental Diseases and Tempromandibular Joints)
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21 pages, 908 KB  
Review
The Oral Microbiome of Peri-Implant Health and Disease: A Narrative Review
by Natalia de Campos Kajimoto, Yvonne de Paiva Buischi, Mansour Mohamadzadeh and Peter Loomer
Dent. J. 2024, 12(10), 299; https://doi.org/10.3390/dj12100299 - 24 Sep 2024
Cited by 17 | Viewed by 9601
Abstract
Peri-implantitis disease has increased significantly over the last years, resulting in increased failure of implants. Many factors may play a role in implant complications and failure, including ones related to the oral microbiota. This literature review aims to summarize the current knowledge of [...] Read more.
Peri-implantitis disease has increased significantly over the last years, resulting in increased failure of implants. Many factors may play a role in implant complications and failure, including ones related to the oral microbiota. This literature review aims to summarize the current knowledge of microbiome of implants in health and disease, focusing not only on the presence/absence of specific microbiota or on their relative abundance, but also on their phenotypic expression and their complex relationships with the host. The authors examined the MEDLINE database and identified key topics about peri-implant oral microbiome in health and disease. The peri-implant microbiome differs from that of the tooth, both in health and disease, as they are structurally and chemically different. The adhesion and formation of the peri-implant biofilm can be affected by the surface energy, topography, wettability, and electrochemical charges of the implant surface. In addition, the morphogenesis of the tissues surrounding the dental implant also differs from the tooth, making the dental implant more susceptible to bacterial infection. This interplay between the microbiome and the host immune system in peri-implant infections still needs to be elucidated. Full article
(This article belongs to the Special Issue Latest Advances in Peri-Implantitis)
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16 pages, 338 KB  
Review
Multifactorial Contributors to the Longevity of Dental Restorations: An Integrated Review of Related Factors
by Maria Jacinta Moraes Coelho Santos, Elham Zare, Peter McDermott and Gildo Coelho Santos Junior
Dent. J. 2024, 12(9), 291; https://doi.org/10.3390/dj12090291 - 12 Sep 2024
Cited by 17 | Viewed by 9780
Abstract
Purpose: This integrated review aims to identify and analyze the multifactorial contributors to the longevity of direct restorations, focusing on tooth-, patient-, and dentist-related factors. Materials and Methods: A search of the literature was performed using an electronic database, PubMed/Medline, Web of Science, [...] Read more.
Purpose: This integrated review aims to identify and analyze the multifactorial contributors to the longevity of direct restorations, focusing on tooth-, patient-, and dentist-related factors. Materials and Methods: A search of the literature was performed using an electronic database, PubMed/Medline, Web of Science, and Scopus, on papers published between 1980 and 2024. The titles and abstracts of papers that evaluated aspects categorized into tooth-related, patient-related, and dentist-related factors influencing restoration failure were selected and screened. Full-text assessments were conducted, and the extracted data were compiled, summarized, and synthesized. The reference lists of the collected papers were also screened, and relevant citations were included in this review. Data were gathered from clinical and laboratorial studies, systematic reviews, and meta-analyses to provide a comprehensive understanding of restoration longevity. Results: Among the tooth-related factors, multiple-surface restorations, deep margins, tooth location, and tooth vitality significantly impact restoration survival. Patient-related factors such as medical conditions, risk predictors of caries, age, sex, parafunctional habits, smoking, periodontal health, number of restorations, and socioeconomic status all play crucial roles. Regarding dentist-related factors, the decision-making process, age, experience, and dentist manual dexterity are vital aspects. Furthermore, the technique used, including isolation methods for moisture control, as well as the type of dental practice (large group vs. small practice), notably influenced the restoration survival. Conclusions: The longevity of dental restorations is influenced by a complex interplay of tooth-related, patient-related, and dentist-related factors. Strategies to improve restoration outcomes should consider all these multifactorial contributors. Continuing professional education, diligent patient guidance on the factors that influence restoration survival, careful material selection and restorative technique, and tailored individual treatment are crucial factors to reduce failure rates and improve the lifespan of restorations. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry)
12 pages, 623 KB  
Article
Color Stability Assessment of Single- and Multi-Shade Composites Following Immersion in Staining Food Substances
by Vittorio Checchi, Eleonora Forabosco, Giulia Della Casa, Shaniko Kaleci, Luca Giannetti, Luigi Generali and Pierantonio Bellini
Dent. J. 2024, 12(9), 285; https://doi.org/10.3390/dj12090285 - 4 Sep 2024
Cited by 10 | Viewed by 3329
Abstract
Composite resins are the material of choice for direct restorations, and their success depends mainly on their color stability, since discoloration causes color mismatch, and consequent patient dissatisfaction. A single- and a multi-shade resin were compared in order to evaluate their pigmentation after [...] Read more.
Composite resins are the material of choice for direct restorations, and their success depends mainly on their color stability, since discoloration causes color mismatch, and consequent patient dissatisfaction. A single- and a multi-shade resin were compared in order to evaluate their pigmentation after immersion in staining substances and to investigate the effect of the polymerization time on their color stability. Two-hundred-and-forty composite specimens were created, half made of a single-shade (Group ONE, n = 120) and half of a multi-shade composite (Group OXP, n = 120). Each group was further divided into ONE30 (n = 60) and OXP30 (n = 60), polymerized for 30″, and ONE80 (n = 60) and OXP80 (n = 60), polymerized for 80″. Randomly, the specimens were immersed in turmeric solution, soy sauce, energy drink, or artificial saliva. By means of a spectrophotometer, ΔE00 and WId were calculated at 24 h (T0), at 7 (T1), and 30 (T2) days. Single-shade composites showed statistically significant differences in color change from the turmeric solution, energy drink, and soy sauce than the multi-shade composites (p < 0.005), showing a higher discoloration potential. The polymerization time did not have significative effects on color stability. Single-shade composites showed more color change than multi-shade systems after immersion in staining substances, and the curing time did not influence color variations. Full article
(This article belongs to the Special Issue State of the Art in Dental Restoration)
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15 pages, 1561 KB  
Article
Dental Color-Matching Ability: Comparison between Visual Determination and Technology
by Maria Menini, Lorenzo Rivolta, Jordi Manauta, Massimo Nuvina, Zsolt M. Kovacs-Vajna and Paolo Pesce
Dent. J. 2024, 12(9), 284; https://doi.org/10.3390/dj12090284 - 3 Sep 2024
Cited by 10 | Viewed by 4646
Abstract
Background: The choice of the correct color is of paramount importance in esthetic dentistry; however, there is still no consensus on the best technique to determine it. The aim of the present study is to compare the accuracy of a recently introduced colorimeter [...] Read more.
Background: The choice of the correct color is of paramount importance in esthetic dentistry; however, there is still no consensus on the best technique to determine it. The aim of the present study is to compare the accuracy of a recently introduced colorimeter in shade matching with human vision. In addition, possible variables affecting color-matching by human eye have been analysed. Methods: 18 disc-shaped composite samples with identical size and shape were produced from a composite flow system (Enamel plus HriHF, Micerium): Nine were considered control samples (UD 0-UD 6), and nine were test samples with identical flow composite shade to the control ones. Parallelly, 70 individuals (dental students and dental field professionals) were individually instructed to sit in a dark room illuminated with D55 light and to perform visual shade matching between control and test discs. An error matrix containing ΔE94 between control and test discs was generated, containing four match-clusters depending on perceptibility and acceptability thresholds. The frequency and severity of errors were examined. Results: The colorimeter achieved a 100% perfect matching, while individuals only achieved a 78%. A higher occurrence of mismatches was noted for intermediate composite shades without a statistically significant difference. No statistically significant differences were reported for age, sex, and experience. A statistically significant difference was present among the Optishade match and the visual determination. Conclusions: The instrumental shade-matching evaluation proved to be significantly more reliable than the human visual system. Further research is needed to determine whether the same outcomes are achieved in a clinical setting directly on patients. Full article
(This article belongs to the Special Issue Esthetic Dentistry: Current Perspectives and Future Prospects)
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18 pages, 19065 KB  
Systematic Review
Correlation between Implant Surface Roughness and Implant Stability: A Systematic Review
by Marta Romero-Serrano, Manuel-María Romero-Ruiz, Mariano Herrero-Climent, Blanca Rios-Carrasco and Javier Gil-Mur
Dent. J. 2024, 12(9), 276; https://doi.org/10.3390/dj12090276 - 23 Aug 2024
Cited by 17 | Viewed by 5563
Abstract
The aim of this study was to find in the literature data on the relationship between implant surface roughness and implant stability achieved, from the time of placement to three months afterward, to help us to know what type of surface roughness is [...] Read more.
The aim of this study was to find in the literature data on the relationship between implant surface roughness and implant stability achieved, from the time of placement to three months afterward, to help us to know what type of surface roughness is more favorable to guarantee implant stability and osseointegration. A systematic review was conducted in accordance with the PRISMA 2020 (Preferred Reporting Items for Systematic Review and Meta-analysis) statement, and the protocol was registered on the Open Science Framework. The specific inclusion and exclusion criteria were selected using the PICOS framework. The databases Medline (PubMed), Scopus, the Web of Science and The Cochrane Library were searched up to October 2023. The selection of studies and data extraction were conducted by two independent reviewers. The review included a total of 11 studies. A total of 1331 dental implant placements were identified. Two of the eleven selected studies were on humans in vivo, eight were on animals in vivo, and one was on animals in vitro. A statistically significant correlation between surface roughness and implant stability as measured by resonance frequency analysis (RFA) was not identified in ten of the eleven selected studies. It appears that there is no correlation between primary stability and the degree of implant roughness. However, there appears to be a correlation between the roughness of the implant and the degree of osseointegration, as indicated by bone-implant contact values. This correlation is more closely related to secondary stability. The great methodological variability makes it difficult to compare data and draw conclusions, so it would be desirable to agree on a common methodology to help draw appropriate conclusions from published studies. Full article
(This article belongs to the Special Issue Risk Factors in Implantology)
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13 pages, 1522 KB  
Systematic Review
Hyaluronic Acid in Bone Regeneration: Systematic Review and Meta-Analysis
by Claudia Lorenzi, Andrea Leggeri, Ilaria Cammarota, Paolo Carosi, Vincenzo Mazzetti and Claudio Arcuri
Dent. J. 2024, 12(8), 263; https://doi.org/10.3390/dj12080263 - 19 Aug 2024
Cited by 22 | Viewed by 6266
Abstract
Aim: The aim of this systematic review and meta-analysis was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when hyaluronic acid (HA) was added and mixed with graft materials in bone regeneration. Materials and methods: This review [...] Read more.
Aim: The aim of this systematic review and meta-analysis was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when hyaluronic acid (HA) was added and mixed with graft materials in bone regeneration. Materials and methods: This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) of the National Institute of Health Research (registration number CRD42024530030). Electronic research was performed, and involved studies published up to 29 February 2024 using a specific word combination. The primary outcome was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when HA was added and mixed with graft materials in bone regeneration. The search resulted in 138 potential studies. Meta-analyses were performed using the fixed and random effects model to identify significant changes in new bone formation and in the remaining graft particles. Results: After screening procedures, only three randomized controlled trials fulfilled the inclusion criteria and were selected for qualitative and quantitative analysis. The effect size of HA in the new bone formation was not statistically significant at 95% CI (Z = 1.734, p-value = 0.083, 95 % CI -,399; 6516). The effect size of HA in the remaining graft particles was not statistically significant at 95% CI (Z = −1.042, p-value = 0.297, CI -,835; 255). Conclusions: Within the limitations of the present systematic review and meta-analysis, the addition of HA to bone graft did not result in significant changes in bone regeneration procedures in terms of new bone formation and residues, even if the included studies showed encouraging and promising results. Full article
(This article belongs to the Special Issue Bone Regeneration and Tissue Reconstruction in Dentistry)
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14 pages, 797 KB  
Review
Peri-Implantitis
by Miriam Ting and Jon B. Suzuki
Dent. J. 2024, 12(8), 251; https://doi.org/10.3390/dj12080251 - 9 Aug 2024
Cited by 23 | Viewed by 13350
Abstract
Peri-implantitis can affect the longevity of successfully integrated implants. Implant success is dependent on reducing the peri-implantitis risk or successfully managing peri-implantitis. Further understanding of peri-implantitis can be derived from its prevalence, microbial and diagnostic findings, existing therapies, and the effects of systemic [...] Read more.
Peri-implantitis can affect the longevity of successfully integrated implants. Implant success is dependent on reducing the peri-implantitis risk or successfully managing peri-implantitis. Further understanding of peri-implantitis can be derived from its prevalence, microbial and diagnostic findings, existing therapies, and the effects of systemic health issues and medication. Based on published information: (1) peri-implantitis is higher in patients who have periodontitis or smoke as well as in implants with 5 years of function; (2) peri-implantitis microflora is different from periodontitis; (3) peri-implantitis risk is increased in patients with cardiovascular diseases and uncontrolled diabetes; (4) most reported peri-implantitis therapies may result in resolution, but the best peri-implantitis treatment is still to be determined; (5) more frequent peri-implant maintenance may reduce risk for peri-implantitis. Full article
(This article belongs to the Special Issue Latest Advances in Peri-Implantitis)
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21 pages, 9535 KB  
Article
Insights into the Cytotoxicity and Irritant Potential of Chlorhexidine Digluconate: An In Vitro and In Ovo Safety Screening
by Stefania Dinu, Anamaria Matichescu, Roxana Buzatu, Iasmina Marcovici, Andreea Geamantan-Sirbu, Alexandra Denisa Semenescu, Remus Christian Bratu and Dana-Cristina Bratu
Dent. J. 2024, 12(7), 221; https://doi.org/10.3390/dj12070221 - 17 Jul 2024
Cited by 14 | Viewed by 4733
Abstract
Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, the potential toxic events arising from its common use in practice has become a subject of increasing concern. Thus, the [...] Read more.
Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, the potential toxic events arising from its common use in practice has become a subject of increasing concern. Thus, the present study was designed to investigate the potential toxicity of CHX digluconate at concentrations covering its antibacterial properties (0.0002–0.2%) in HGF primary gingival fibroblasts, HaCaT immortalized human keratinocytes, and JB6 Cl 41-5a epidermal cells, as well as its irritant action in ovo. Our results indicate that CHX exerted a concentration- and time-dependent cytotoxicity in all cell lines, which was evidenced by the reduction in cell viability, number, and confluence, damaged cell membrane integrity, impaired cell morphology, and specific apoptotic nuclear shape. The highest cytotoxicity was caused by CHX digluconate 0.02% and 0.2%, concentrations, at which an irritant effect on the chorioallantoic membrane was also observed. The novel findings revealed in this research contribute to the overall safety profile of CHX and stand as a basis for further investigations in this regard. Full article
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11 pages, 259 KB  
Article
The Role of Malocclusion and Oral Parafunctions in Predicting Signs and Symptoms of Temporomandibular Disorders—A Cross-Sectional Study
by Luka Šimunović, Marina Lapter Varga, Dubravka Negovetić Vranić, Ivana Čuković-Bagić, Lana Bergman and Senka Meštrović
Dent. J. 2024, 12(7), 213; https://doi.org/10.3390/dj12070213 - 10 Jul 2024
Cited by 12 | Viewed by 3407
Abstract
Background: The aim of this study was to examine to what extent malocclusion and parafunctional habits contribute to the development of signs and symptoms associated with temporomandibular disorders (TMD) in schoolchildren with mixed dentition in Croatia in a sample of 338 children, aged [...] Read more.
Background: The aim of this study was to examine to what extent malocclusion and parafunctional habits contribute to the development of signs and symptoms associated with temporomandibular disorders (TMD) in schoolchildren with mixed dentition in Croatia in a sample of 338 children, aged 9 to 15 years. Methods: TMD signs and symptoms assessed by the clinician were joint function and pain, masticatory muscles tenderness, range of mandibular motion, and joint sounds. To evaluate subjective symptoms and parafunctions, children and parents were asked about the presence of headaches, jaw locking, temporomandibular joint (TMJ) sounds, pain during mouth opening, or bruxism, as well as parafunctions like biting pencils or nails, chewing hard candies or ice, daily gum chewing, opening bottles with teeth, engaging in jaw play, thumb-sucking, and clenching/grinding teeth. Results: At least one symptom of a TMD was pronounced in 142 participants (42.0%). The most commonly reported parafunction was pencil or nail biting, present in 25.1% of participants. Class II malocclusion increased the likelihood by 2.6 times, pencil or nail biting by 2.34 times, and clenching/grinding teeth by 8.9 times that the subject would exhibit at least one TMD symptom. Conclusions: Every child with mixed dentition should undergo a brief examination of the TMJ, especially in cases of Class II malocclusion, pencil or nail biting, and teeth clenching or grinding, as these have all been identified as significant risk factors that increase the likelihood of experiencing TMD symptoms. This highlights the need for proactive screening and assessment by healthcare providers to reduce the risk and prevalence of TMDs in affected children and ensure timely diagnosis and treatment. Full article
(This article belongs to the Special Issue Feature Papers to Celebrate the First Impact Factor of Dentistry Journal)
18 pages, 707 KB  
Systematic Review
Clinical Factors on Dental Implant Fractures: A Systematic Review
by Mattia Manfredini, Pier Paolo Poli, Luca Giboli, Mario Beretta, Carlo Maiorana and Matteo Pellegrini
Dent. J. 2024, 12(7), 200; https://doi.org/10.3390/dj12070200 - 28 Jun 2024
Cited by 22 | Viewed by 6867
Abstract
Dental implant fractures pose a significant challenge to long-term treatment success. This systematic review aims to comprehensively examine the clinical factors influencing dental implant fractures (IFs). Furthermore, strategies to choose the right type of implant and prevent this complication are addressed. A systematic [...] Read more.
Dental implant fractures pose a significant challenge to long-term treatment success. This systematic review aims to comprehensively examine the clinical factors influencing dental implant fractures (IFs). Furthermore, strategies to choose the right type of implant and prevent this complication are addressed. A systematic search was conducted across PubMed, Scopus, and Web of Science databases. Eligible studies included retrospective case–control, prospective cohort studies, and clinical trials. The initial search yielded 361 articles, of which 312 were excluded being these reviews, case reports, irrelevant, or written in languages other than English. This left 49 articles, with only 6 meeting the eligibility criteria for an in-depth review. These studies, all retrospective case–control, examine implant characteristics, patient demographics, surgical and prosthetic variables, biomechanical and functional factors, clinical and procedural variables, complications and maintenance issues. The risk of bias was assessed as low using the ROBINS-I tool. Key findings suggest a correlation between implant diameter and structural resistance, with wider implants demonstrating reduced fracture risk. Additionally, posterior regions, especially molars and premolars, exhibit higher susceptibility to IFs due to increased masticatory forces. Implant design and material may considerably influence fracture risk, with conical implants and screw-retained prostheses showing higher vulnerability. Biomechanical overload, particularly in patients with bruxism, emerges as a primary contributing factor to IFs. Prosthesis type significantly influences fracture incidence, with cantilever prostheses posing a higher risk due to increased stress. Peri-implant bone loss is strongly associated with IFs, emphasizing the need for meticulous preoperative assessments and individualized management strategies. Future research should prioritize larger and heterogeneous populations with long-term follow-up and standardized methodologies to enhance the generalizability and comparability of findings. Randomized controlled trials and biomechanical studies under controlled conditions are also essential to elucidate the complex interactions contributing to IFs and developing effective prevention strategies. Additionally, integrating patient-reported outcomes may offer a comprehensive understanding of the impact of IFs on quality of life. Full article
(This article belongs to the Special Issue Risk Factors in Implantology)
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10 pages, 2875 KB  
Article
Implementation of Patient-Individualized 3D-Printed Models in Undergraduate Students’ Education for Various Prosthetic Treatments: A Cross-Sectional Survey Study
by Andrea Klink, Fabian Engelskirchen, Pablo Kaucher-Fernandez, Fabian Huettig and Ariadne Roehler
Dent. J. 2024, 12(7), 199; https://doi.org/10.3390/dj12070199 - 27 Jun 2024
Cited by 6 | Viewed by 1821
Abstract
Background: Due to rapid changes in dental practice, digital technologies have become prominent in undergraduate dental education at German universities in recent years. This shift has prompted a re-evaluation of content as well as teaching methods, particularly in courses where students are prepared [...] Read more.
Background: Due to rapid changes in dental practice, digital technologies have become prominent in undergraduate dental education at German universities in recent years. This shift has prompted a re-evaluation of content as well as teaching methods, particularly in courses where students are prepared for patient treatment. Traditional training on standardized models with resin teeth cannot cover the complexity of individual dental arch configuration encountered in patient situations. This study explores the use of 3D printing technology to create individualized models for prosthetic treatment simulations, aiming to evaluate students’ feedback towards their experience with this training setting. Methods: First, the study describes the design and fabrication of individualized models with exchangeable teeth based on intraoral scans, mounted on connected plates with distance holders that can be fixed to standard phantom heads. Second, students provided feedback through a questionnaire, assessing various aspects such as the effectiveness of the 3D-printed models compared to traditional frasaco models for preparation exercises. Results: The results indicated that the design of the realized models was feasible for preparation training (question no. 4: 93% positive rating) and showed positive perceptions of the 3D-printed models, with students finding them effective for preparation exercises and beneficial in bridging the gap between simulation and real patient situations (question no. 6: 69% positive rating). Conclusions: The study suggests that 3D printing technology offers a valuable tool in dental education, providing realistic and patient-specific scenarios for students to enhance their skills and readiness for clinical practice. Further improvements in material properties in hand with cost-effective approaches are essential for widespread implementation. Full article
(This article belongs to the Special Issue Feature Papers in Digital Dentistry)
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13 pages, 569 KB  
Article
Investigating the Relationship between Oral Health and Severe Mental Illness: Analysis of NHANES 1999–2016
by Jing Kang, Jianhua Wu, Vishal. R. Aggarwal, David Shiers, Tim Doran and Jasper Palmier-Claus
Dent. J. 2024, 12(7), 191; https://doi.org/10.3390/dj12070191 - 24 Jun 2024
Cited by 9 | Viewed by 3856
Abstract
Objectives: To explore whether: (i) people with severe mental illness (SMI) experience worse oral health than the general population, and (ii) the risk factors for poor oral health in people with SMI. Methods: Cross-sectional data were extracted from the National Health and Nutrition [...] Read more.
Objectives: To explore whether: (i) people with severe mental illness (SMI) experience worse oral health than the general population, and (ii) the risk factors for poor oral health in people with SMI. Methods: Cross-sectional data were extracted from the National Health and Nutrition Examination Survey (1999–2016), including on self-rated oral health, oral pain, tooth loss, periodontitis stage, and number of decayed, missing, and filled teeth. Candidate risk factors for poor oral health included demographic characteristics, lifestyle factors, physical health comorbidities, and dental hygiene behaviours. Ordinal logistic regression and zero-inflated negative binomial models were used to explore predictors of oral health outcomes. Results: There were 53,348 cases included in the analysis, including 718 people with SMI. In the fully adjusted model, people with SMI were more likely to suffer from tooth loss (OR 1.60, 95% CI: 1.34–1.92). In people with SMI, risk factors identified for poor oral health outcomes were older age, white ethnicity, lower income, smoking history, and diabetes. Engaging in physical activity and daily use of dental floss were associated with better oral health outcomes. Conclusions: People with SMI experience higher rates of tooth loss than the general population, and certain subgroups are particularly at risk. Performing regular physical exercise and flossing may lower the risk of poor oral health, while smoking and diabetes may increase the risk. These findings suggest opportunities for targeted prevention and early intervention strategies to mitigate adverse oral health outcomes in people with SMI. Full article
(This article belongs to the Special Issue Feature Papers to Celebrate the First Impact Factor of Dentistry Journal)
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16 pages, 822 KB  
Review
Iron Deficiency Anemia and Its Impact on Oral Health—A Literature Review
by Kabilan Velliyagounder, Krupa Chavan and Kenneth Markowitz
Dent. J. 2024, 12(6), 176; https://doi.org/10.3390/dj12060176 - 7 Jun 2024
Cited by 10 | Viewed by 11976
Abstract
Oral disease interventions primarily focus on behavioral changes like dietary improvements and ensuring better oral hygiene. However, recognizing the influence of biological factors, including genetics and early-life nutrition, is crucial. Iron deficiency (ID) and its advanced form, iron deficiency anemia (IDA), affect nearly [...] Read more.
Oral disease interventions primarily focus on behavioral changes like dietary improvements and ensuring better oral hygiene. However, recognizing the influence of biological factors, including genetics and early-life nutrition, is crucial. Iron deficiency (ID) and its advanced form, iron deficiency anemia (IDA), affect nearly two billion people globally, especially children and pregnant women. We conducted a comprehensive search using Medline via EndNote and Web of Science, employing keywords related to iron deficiency anemia (IDA), and we identified 36 studies deemed relevant for inclusion in this literature review. IDA prevalence is notably high among pregnant women and young children. Both IDA and early-childhood caries (ECC) disproportionately affect impoverished populations, highlighting the socioeconomic dimension of this issue. IDA presents with various oral mucosal changes and is closely linked to candidiasis. Additionally, IDA can hinder tooth development and weaken the immune response. Multiple population surveys have revealed a significant association between ECC and IDA. While some studies have explored the IDA–periodontal disease link, the current evidence is relatively limited in its robustness. In conclusion, more comprehensive longitudinal studies are essential to deepen our understanding of the IDA–oral disease connection. Investigating the underlying biological mechanisms is critical to developing effective interventions, particularly for vulnerable populations affected by IDA. Full article
(This article belongs to the Section Oral Hygiene, Periodontology and Peri-implant Diseases)
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14 pages, 3604 KB  
Systematic Review
The Treatment and Management of Oroantral Communications and Fistulas: A Systematic Review and Network Metanalysis
by Stefano Oliva, Felice Lorusso, Antonio Scarano, Maurizio D’Amario and Giovanna Murmura
Dent. J. 2024, 12(5), 147; https://doi.org/10.3390/dj12050147 - 20 May 2024
Cited by 21 | Viewed by 14328
Abstract
Objectives: The aim of this work was to systematically review and carry out a statistical metanalysis to identify the best treatment for close oroantral communications and fistulas and to avoid the risk of recurrence. Materials and Methods: An electronic search was conducted on [...] Read more.
Objectives: The aim of this work was to systematically review and carry out a statistical metanalysis to identify the best treatment for close oroantral communications and fistulas and to avoid the risk of recurrence. Materials and Methods: An electronic search was conducted on the MEDLINE database (Pubmed), Scopus, and Google scholar using the following keywords: “oro antral communication (OAC)” OR “oro antral fistula (OAF)” OR “antro-oral communication” OR “communication between maxillary sinus and oral cavity” OR “oro-sinusal communication” OR “oro-sinusal fistula” OR “sinus communication” OR “sinus fistula” OR “antral communication” AND “treatment” OR “management” OR “surgical treatment” OR “surgical interventions”. This work was performed in accordance with the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). After article screening, 9 RCTs (randomized controlled trials), comparing two or more techniques, were included in this review. Results: A statistically significant difference was detected in favor of the buccal fat pad compared to the buccal advancement flap and palatal rotational flap. Conclusions: With the limitations of this study, the buccal fat pad showed the best results in terms of communication closure and reducing the risk of relapse. Full article
(This article belongs to the Section Oral and Maxillofacial Surgery)
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13 pages, 584 KB  
Article
Clinical Use of Paraprobiotics for Pregnant Women with Periodontitis: Randomized Clinical Trial
by Andrea Butera, Maurizio Pascadopoli, Maria Gloria Nardi, Chiara Ogliari, Alessandro Chiesa, Camilla Preda, Giulia Perego and Andrea Scribante
Dent. J. 2024, 12(4), 116; https://doi.org/10.3390/dj12040116 - 19 Apr 2024
Cited by 50 | Viewed by 4115
Abstract
Periodontal disease is very common in pregnant women. Paraprobiotics are a subset of probiotics. They can be defined as inactivated microbial cells providing health benefits to the host and are considered particularly safe. The aim of this study was to compare the periodontal [...] Read more.
Periodontal disease is very common in pregnant women. Paraprobiotics are a subset of probiotics. They can be defined as inactivated microbial cells providing health benefits to the host and are considered particularly safe. The aim of this study was to compare the periodontal health of pregnant women and puerperae after 6 months of home use of paraprobiotics. A total of 30 pregnant women were enrolled and divided into two groups: the test group, who had to use a paraprobiotic-based toothpaste (Biorepair Peribioma Pro, Coswell S.p.A., Funo di Argelato, BO, Italy) and mousse (Mousse Mouthwash Biorepair Peribioma, Coswell S.p.A.) twice a day, and the control group, who had to use only the paraprobiotic-based toothpaste. The time frames of the study were: 1 month (T1), 3 months (T2) and 6 months (T3), and data were collected during pregnancy and in the period immediately following delivery. The following indices were evaluated at T0, T1, T2 and T3: clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), plaque control record (PCR), modified marginal gingival index (mMGI), papillary marginal gingival index (PMGI) and recessions (R). All data were subjected to statistical analysis. PCR decreased significantly from T0 to T1 in the control group and from T0 to T2 and from T0 to T3 in the test group. BOP tended to decrease in both groups, but a significant reduction was observed only in the test group. CAL, PPD, PMGI and mMGI tended to decrease gradually in both groups without significant differences between or within groups. The combination of the paraprobiotic-based toothpaste and the paraprobiotic-based mousse significantly reduced BoP and plaque control over time, although there were no significant differences with the use of the paraprobiotic-based toothpaste alone. In addition, the combination of the two products promoted a trend towards the better stabilization of recessions. Full article
(This article belongs to the Special Issue Rising Stars: Oral Infections and Microbes)
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12 pages, 599 KB  
Review
Different Methods of Teaching and Learning Dental Morphology
by Helene Lindén Overskott, Caroline Elisabet Markholm, Amer Sehic and Qalbi Khan
Dent. J. 2024, 12(4), 114; https://doi.org/10.3390/dj12040114 - 18 Apr 2024
Cited by 16 | Viewed by 5772
Abstract
Dental anatomy education is traditionally structured into theoretical and practical modules to foster both cognitive and psychomotor development. The theoretical module typically involves didactic lectures where educators elucidate dental structures using visual aids. In contrast, practical modules utilize three-dimensional illustrations, extracted and plastic [...] Read more.
Dental anatomy education is traditionally structured into theoretical and practical modules to foster both cognitive and psychomotor development. The theoretical module typically involves didactic lectures where educators elucidate dental structures using visual aids. In contrast, practical modules utilize three-dimensional illustrations, extracted and plastic teeth, and tooth carving exercises on wax or soap blocks, chosen for their cost, ease of handling, and fidelity in replication. However, the efficacy of these traditional methods is increasingly questioned. The criticism in this concern is that oversized carving materials may distort students’ understanding of anatomical proportions, potentially affecting the development of necessary skills for clinical practice. Lecture-driven instruction, on the other hand, is also criticized for its limitations in fostering interactive learning, resulting in a gap between pre-clinical instruction and practical patient care. In this study, we review the various educational strategies that have emerged to enhance traditional dental anatomy pedagogy by describing the effectiveness of conventional didactic lectures, wax carving exercises, the use of real and artificial teeth, the flipped classroom model, and e-learning tools. Our review aims to assess each method’s contribution to improving clinical applicability and educational outcomes in dental anatomy, with a focus on developing pedagogical frameworks that align with contemporary educational needs and the evolving landscape of dental practice. We suggest that the optimal approach for teaching tooth morphology would be to integrate the digital benefits of the flipped classroom model with the practical, hands-on experience of using extracted human teeth. To address the challenges presented by this integration, the creation and standardization of three-dimensional tooth morphology educational tools, complemented with concise instructional videos for a flipped classroom setting, appears to be a highly effective strategy. Full article
(This article belongs to the Section Dental Education)
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20 pages, 3499 KB  
Review
The Impact of Vitamin Deficiencies on Oral Manifestations in Children
by Stjepanka Lešić, Zrinka Ivanišević, Bruno Špiljak, Matej Tomas, Magdalena Šoštarić and Aleksandar Včev
Dent. J. 2024, 12(4), 109; https://doi.org/10.3390/dj12040109 - 17 Apr 2024
Cited by 14 | Viewed by 24149
Abstract
Vitamins play a vital role in human health, particularly in the development and maintenance of oral health in children. These nutrients are broadly categorized into fat-soluble and water-soluble types, crucial for children’s well-being. The objective of this study is to investigate the impact [...] Read more.
Vitamins play a vital role in human health, particularly in the development and maintenance of oral health in children. These nutrients are broadly categorized into fat-soluble and water-soluble types, crucial for children’s well-being. The objective of this study is to investigate the impact of vitamin deficiencies on the oral health of children, focusing on how these deficiencies contribute to various oral health issues and determining the relationship between specific vitamin shortages and oral diseases. Findings indicate that shortages in vitamins A and D lead to enamel issues and a higher susceptibility to dental diseases, vitamin E assists in treating oral mucositis, and vitamin K is essential for blood clotting in dental surgeries. Deficits in B-complex and vitamin C result in enamel hypomineralization and soft tissue ailments, including aphthous stomatitis and gingival petechiae. Additionally, a lack of vitamin B7 compromises the immune response, increasing oral candidiasis risk. Therefore, vitamin deficiencies markedly affect children’s oral health, highlighting the need for joint efforts between dental professionals and caregivers for effective pediatric care. Addressing vitamin deficiencies through supplementation and tailored dental care emphasizes the significance of nutritional health in children’s overall and dental well-being, advocating for a collaborative approach to achieve optimal health outcomes. Full article
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases: Volume II)
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14 pages, 1772 KB  
Article
Perceptions in Digital Smile Design: Assessing Laypeople and Dental Professionals’ Preferences Using an Artificial-Intelligence-Based Application
by Smaranda Buduru, Florin Cofar, Anca Mesaroș, Manuela Tăut, Marius Negucioiu and Oana Almășan
Dent. J. 2024, 12(4), 104; https://doi.org/10.3390/dj12040104 - 11 Apr 2024
Cited by 10 | Viewed by 6102
Abstract
Digital Smile Design (DSD) is used in many fields of dentistry. This prospective observational study assessed laypeople’s and dental professionals’ perceptions of a DSD application. SmileCloud, an online DSD platform, was used to create two different designs for three patients; after that, the [...] Read more.
Digital Smile Design (DSD) is used in many fields of dentistry. This prospective observational study assessed laypeople’s and dental professionals’ perceptions of a DSD application. SmileCloud, an online DSD platform, was used to create two different designs for three patients; after that, the participants, in a 30-question online illustrated survey, were asked about the most attractive design and other features of the smile. Dentists’ and laypeople’s perceptions about specific DSD features were assessed. The Kolmogorov–Smirnov normality test was used. Descriptive and crosstab analyses compared the respondents’ opinions for each statement. Chi-square tests were used to determine the relationship between the questions and any association with age, gender, and profession. The test results were rated as significant at a p-value < 0.05. A total of 520 participants (dental professionals, students, dental technicians, and laypeople) were enrolled. The statistically significant features were self-esteem related to appearance (p = 0.05), facial and smile symmetry (p = 0.42, p < 0.0001), tooth color (p = 0.012), and symmetry of gums (p < 0.001). For each patient, the design with dominant round upper incisors and perfect symmetry was preferred (p < 0.001). Digital pre-visualization benefits diagnosis and enriches treatment planning. The dentist–dental technician–patient team should be involved in the decision-making process of pre-visualization. Full article
(This article belongs to the Section Digital Technologies)
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27 pages, 634 KB  
Systematic Review
Effectiveness of Autologous Platelet Concentrates in the Sinus Lift Surgery: Findings from Systematic Reviews and Meta-Analyses
by Roberta Gasparro, Alessandro Espedito Di Lauro, Maria Domenica Campana, Nicola Rosiello, Mauro Mariniello, Gilberto Sammartino and Gaetano Marenzi
Dent. J. 2024, 12(4), 101; https://doi.org/10.3390/dj12040101 - 10 Apr 2024
Cited by 8 | Viewed by 3344
Abstract
Maxillary sinus augmentation is one of the most predictable procedures for the rehabilitation of the posterior maxilla. The current overview aimed to summarize the findings provided by systematic reviews (SRs) and meta-analyses on the effectiveness of autologous platelet concentrates (APCs) in sinus lift [...] Read more.
Maxillary sinus augmentation is one of the most predictable procedures for the rehabilitation of the posterior maxilla. The current overview aimed to summarize the findings provided by systematic reviews (SRs) and meta-analyses on the effectiveness of autologous platelet concentrates (APCs) in sinus lift and to assess the methodological quality of the included SRs. Three electronic databases have been explored. SRs and meta-analyses addressing the effectiveness of APCs in sinus lift technique were included. Clinical, radiographic and histomorphometric findings were considered for APCs as solely grafting materials and APCs in combination with biomaterials. Outcomes were implant survival rate (ISR), implant stability (IS), implant failure (IF), postoperative complications, histomorphometric findings, radiographic bone gain, bone volume and bone density. The methodological quality of the included SRs was assessed using the updated version of “A Measurement Tool to Assess Systematic Review” (AMSTAR-2). Thirty SRs were included. The methodological quality of the included reviews ranged from critically low (3 studies) to high (9 studies). The included SRs showed favorable clinical outcomes, short-term new bone formation and no biological complications when APCs were used both as solely graft material or in combination with other biomaterials. However, no significant additional effects in the long-term period were observed. APCs did not add any further positive effects compared to the physiological healing derived by the natural blood clot. The current overview of SRs highlighted the need for high-quality SRs evaluating the role of APCs in sinus lift though network meta-analyses, in order to identify the most powerful material for sinus lift augmentation. The use of APCs improves the healing of soft tissues and the postoperative quality of life in the short-term period. Thus, its application can be recommended. Full article
(This article belongs to the Special Issue Current and Future Trends in Maxillary Sinus Management: Perspectives in Oral Surgery)
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13 pages, 2428 KB  
Article
Vacuum Plasma Treatment Device for Enhancing Fibroblast Activity on Machined and Rough Titanium Surfaces
by Luigi Canullo, Tullio Genova, Giorgia Chinigò, Roberta Iacono, Paolo Pesce, Maria Menini and Federico Mussano
Dent. J. 2024, 12(3), 71; https://doi.org/10.3390/dj12030071 - 7 Mar 2024
Cited by 8 | Viewed by 2778
Abstract
This study was conducted to compare the effects of an innovative plasma surface treatment device that does not need a gas supply for titanium disks with two different surface topographies: the prototypical machined surface (MAC) and one of the most diffused roughened ones [...] Read more.
This study was conducted to compare the effects of an innovative plasma surface treatment device that does not need a gas supply for titanium disks with two different surface topographies: the prototypical machined surface (MAC) and one of the most diffused roughened ones (SL) obtained through grit blasting and acid etching. A total of 200-MAC and 200-SL titanium disks were used. Each group of disks was divided into four sub-groups of 40 samples each that were subjected to five different tests. Among these, 150-MAC and 150-SL were considered the test group, and they were treated with plasma for 15, 30, and 60 s after being removed from the sterile packaging. On the other hand, 50-MAC and 50-SL were considered the control group, and they were only removed from sterile plastic vials. The samples were analyzed to evaluate the capability of the plasma treatment in influencing protein adsorption, cell adhesion, proliferation, and microbial growth on the test group disks when compared to the untreated disks. Protein adsorption was significantly enhanced after 20 min of plasma treatment for 15 and 30 s on the MAC and SL disks. Plasma treatment for 15 and 30 s significantly increased the level of adhesion in both treated samples after 30 min. Furthermore, the MAC samples showed a significant increase in cell adhesion 4 h after plasma treatment for 15 s. The SEM analysis highlighted that, on the treated samples (especially on the MAC disks), the cells with a polygonal and flat shape prevailed, while the fusiform- and globular-shaped cells were rare. The encouraging results obtained further confirm the effectiveness of plasma treatments on cell adhesion and fibroblast activity. Full article
(This article belongs to the Special Issue Feature Papers in Digital Dentistry)
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12 pages, 4492 KB  
Article
Influence of Post-Curing in Nitrogen-Saturated Condition on the Degree of Conversion and Color Stability of 3D-Printed Resin Crowns
by Bohyun Lim, Dohyun Kim, Je Seon Song, Sunil Kim, Hoon Kim and Yooseok Shin
Dent. J. 2024, 12(3), 68; https://doi.org/10.3390/dj12030068 - 6 Mar 2024
Cited by 8 | Viewed by 4449
Abstract
Post-curing is the process of applying extra light to complete the polymerization process of 3D printing. The mechanical properties of light-cured three-dimensional (3D) printed resin can be improved by decreasing the oxygen concentrations during post-curing, and nitrogen-saturated post-curing has been applied for this [...] Read more.
Post-curing is the process of applying extra light to complete the polymerization process of 3D printing. The mechanical properties of light-cured three-dimensional (3D) printed resin can be improved by decreasing the oxygen concentrations during post-curing, and nitrogen-saturated post-curing has been applied for this purpose. This study aimed to evaluate and compare the color stability of 3D-printed resin crowns that were post-cured in both normal air and nitrogen-saturated conditions. Crowns were fabricated with a 3D printer and post-cured in normal air (control group; air) or nitrogen-saturated conditions (experimental group; nitrogen). The specimens in each group were subdivided into four subgroups, each exposed to different discoloration agents: distilled water, coffee, wine, and curry. Post-immersion color changes were measured using a digital spectrophotometer and analyzed using repeated-measures ANOVA. Fourier transform infrared (FT-IR) spectroscopy evaluated the degree of conversion of resin over immersion times for both post-curing conditions. Upon comparing the effects of post-curing conditions, a significant difference between the control and experimental groups in terms of immersion time in the wine and curry subgroups was found. FT-IR analysis showed a significant difference in the degree of conversion between the air and nitrogen groups from 10 to 300 s. These findings suggest that nitrogen-saturated post-curing can potentially enhance the conversion rate of 3D-printed resin crowns, thereby improving their color stability. Full article
(This article belongs to the Topic Advances in Dental Health)
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17 pages, 3084 KB  
Article
Mobile Application-Based Support for Periodontal Treatment Improves Clinical, Cognitive, and Psychomotor Outcomes: A Randomized Controlled Trial Study
by Valdy Hartono, Yoga Setiadharma, Aurelle Khadeeja Rizany, Benso Sulijaya, Robert Lessang, Natalina Haerani, Ette S. Tadjoedin, Sri Lelyati C. Masulili, Fatimah Maria Tadjoedin, Yuniarti Soeroso and Marie Rossini Carmela T. Lachica
Dent. J. 2024, 12(3), 63; https://doi.org/10.3390/dj12030063 - 4 Mar 2024
Cited by 10 | Viewed by 4387
Abstract
This study aims to evaluate the clinical, cognitive, and psychomotor changes that emerged among patients with gingivitis and patients with periodontitis via mobile application assistance. Forty subjects were randomly and evenly distributed into test and control groups and were administered a professional mechanical [...] Read more.
This study aims to evaluate the clinical, cognitive, and psychomotor changes that emerged among patients with gingivitis and patients with periodontitis via mobile application assistance. Forty subjects were randomly and evenly distributed into test and control groups and were administered a professional mechanical plaque removal (PMPR) procedure. The clinical parameters examined were bleeding on probing (BoP), probing pocket depth (PPD), and the oral hygiene index (OHI-S). The test group was administered a mobile application intervention, namely PerioUICare, which provided users with continuous education and motivation and served as a daily dental hygiene reminder. The comparative results of the mean values of all parameters between the groups (inter-group) and within the groups (intra-group) after one- and three-month evaluations were analyzed. A one-month inter-group evaluation uncovered significant differences in the BoP, PPD, cognitive, and psychomotor scores of subjects with gingivitis and the BoP, OHI-S, cognitive, and psychomotor scores of subjects with periodontitis. A three-month inter-group evaluation revealed significant differences across all parameters except for PPD in subjects with periodontitis. The results of the intra-group comparison demonstrated statistically significant differences in all parameters in the test group but no significant differences in the cognitive and psychomotor scores of the control group. This study revealed that mobile application-based support for periodontal treatment can be considered effective. Full article
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13 pages, 892 KB  
Review
Does Miniscrew-Assisted Rapid Palatal Expansion Influence Upper Airway in Adult Patients? A Scoping Review
by Mariachiara Benetti, Luca Montresor, Daniele Cantarella, Nicoletta Zerman and Enrico Spinas
Dent. J. 2024, 12(3), 60; https://doi.org/10.3390/dj12030060 - 1 Mar 2024
Cited by 11 | Viewed by 8246
Abstract
(1) Objective: This scoping review evaluates the effects of miniscrew-assisted rapid palatal expansion (MARPE) on different regions of the upper airway in adult patients and investigates various methods of measurement. (2) Methods: The search encompassed Pubmed, Cochrane Library, Scopus and Web of Science. [...] Read more.
(1) Objective: This scoping review evaluates the effects of miniscrew-assisted rapid palatal expansion (MARPE) on different regions of the upper airway in adult patients and investigates various methods of measurement. (2) Methods: The search encompassed Pubmed, Cochrane Library, Scopus and Web of Science. This review was conducted following the PRISMA_ScR guidelines, and the inclusion criteria for examined studies were chosen in accordance with the PICOS framework. (3) Results: Seven studies were included in this review, comprising four retrospective studies, one prospective and two case reports. All studies involved the use of Cone Beam Computed Tomography (CBCT) for measurements of the areas of interest. The percentage of increase in the volume of the nasal cavity varied between 31% and 9.9%, depending on the study. Volumetric variations in the nasopharynx were reported as increases between T0 (before expansion) and T1 (immediately after expansion) of 6.4%, 20.7% and 14.1%. All studies considered T0 before expansion and T1 immediately after expansion. Only one study evaluated remote follow-up to assess if the results were maintained after one year. (4) Conclusions: MARPE appears to lead to a statistically significant increase in the upper airway, especially in the nasal cavity and nasopharynx immediately after expansion. However, further prospective and retrospective trails with long-term controls are required to verify the effects of MARPE on the upper airway. Full article
(This article belongs to the Special Issue Tradition and Innovation in Orthodontics)
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15 pages, 3453 KB  
Article
GDF15 Contributes to the Regulation of the Mechanosensitive Responses of PdL Fibroblasts through the Modulation of IL-37
by Julia Steinmetz, Albert Stemmler, Christoph-Ludwig Hennig, Judit Symmank and Collin Jacobs
Dent. J. 2024, 12(2), 39; https://doi.org/10.3390/dj12020039 - 13 Feb 2024
Cited by 7 | Viewed by 3202
Abstract
During orthodontic tooth movement (OTM), areas of compressive and tensile forces are generated in the periodontal ligament (PdL), a mechanoreactive connective tissue between the teeth and alveolar bone. Mechanically stimulated PdL fibroblasts (PdLFs), the main cell type of PdL, express significantly increased levels [...] Read more.
During orthodontic tooth movement (OTM), areas of compressive and tensile forces are generated in the periodontal ligament (PdL), a mechanoreactive connective tissue between the teeth and alveolar bone. Mechanically stimulated PdL fibroblasts (PdLFs), the main cell type of PdL, express significantly increased levels of growth differentiation factor 15 (GDF15). In compressed PdL areas, GDF15 plays a fundamental role in modulating relevant OTM processes, including inflammation and osteoclast activation. However, the specific function of this factor in tensile areas has not yet been investigated. Thus, the aim of this study was to investigate the role of GDF15 in the mechanoresponse of human PdLFs (hPdLFs) that were exposed to biaxial tensile forces in vitro. Using siRNA-mediated knockdown experiments, we demonstrated that GDF15 had no impact on the anti-inflammatory force response of elongated hPdLFs. Although the anti-inflammatory markers IL1RN and IL10, as well as the activation of immune cells remained unaffected, we demonstrated an inhibitory role of GDF15 for the IL-37 expression. By analyzing osteogenic markers, including ALPL and RUNX2, along with an assessment of alkaline phosphatase activation, we further showed that the regulation of IL-37 by GDF15 modulates the osteogenic differentiation potential of hPdLFs. Despite bone resorption in tensile areas being rather limited, GDF15 was also found to positively modulate osteoclast activation in those areas, potentially by adjusting the IL-37 levels. In light of our new findings, we hypothesize that GDF15 modulates force-induced processes in tissue and bone remodeling through its various intra- and extracellular signaling pathways as well as interaction partners. Potentially acting as a master regulator, the modulation of GDF15 levels may hold relevance for clinical implications. Full article
(This article belongs to the Special Issue Current Research Topics in Orthodontics)
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12 pages, 3157 KB  
Article
Effect of Duplication Techniques on the Fitting Accuracy of CAD-CAM Milled, 3D-Printed, and Injection-Molded Mandibular Complete Denture Bases
by Abdel-Naser M. Emam, Ahmed Ayman El-Esawy, Mohammed Hamad Alyami, Yasser Baraka, Mohammed M. Gad and Mohamed Ahmed Helal
Dent. J. 2024, 12(2), 32; https://doi.org/10.3390/dj12020032 - 2 Feb 2024
Cited by 5 | Viewed by 4412
Abstract
Background: Digital technology has been introduced in prosthodontics, and it has been widely used in denture duplication instead of a conventional denture duplication technique. However, research comparing different denture duplication techniques and how they affect the fitting accuracy of the denture base is [...] Read more.
Background: Digital technology has been introduced in prosthodontics, and it has been widely used in denture duplication instead of a conventional denture duplication technique. However, research comparing different denture duplication techniques and how they affect the fitting accuracy of the denture base is scarce. Objectives: The aim was to assess the impact of duplication techniques on the accuracy of the fitting surface of computer-aided design and manufacturing (CAD-CAM) milled, 3D-printed, and injection-molded complete denture bases (CDBs). Methodology: This study involved fabricating a mandibular complete denture base with three marked dimples as reference marks (A, B, and C at the incisive papilla, right molar, and left molar areas) using a conventional compression molded technique. This denture was then scanned to generate a standard tessellation language (STL) file; after that, it was duplicated using three different techniques (milling, 3D printing, and injection molding) and five denture base resin materials—two milled CAD-CAM materials (AvaDent and IvoBase), two 3D-printed materials (NextDent and HARZ Labs), and one injection-molded material (iFlextm). Based on the denture base type, the study divided them into five groups (each with n = 10). An evaluation of duplication accuracy was conducted on the fitting surface of each complete denture base (CDB) using two assessment methods. The first method was a two-dimensional evaluation, which entailed linear measurements of the distances (A–B, A–C, and B–C) between reference points on both the scanned reference mandibular denture and the duplicated dentures. Additionally, a three-dimensional superimposition technique was employed, involving the overlay of the STL files of the dentures onto the reference denture’s STL file. The collected data underwent statistical analysis using a one-way analysis of variance and Tukey’s pairwise post hoc tests. Results: Both evaluation techniques showed significant differences in fitting surface accuracy between the tested CDBs (p ˂ 0.001), as indicated by one-way ANOVA. In addition, the milled CDBs (AvaDent and IvoBase) had significantly higher fitting surface accuracy than the other groups (p ˂ 0.001) and were followed by 3D-printed CDBs (NextDent and HARZ Labs), while the injection-molded (iFlextm) CDBs had the lowest accuracy (p ˂ 0.001). Conclusions: The duplication technique of complete dentures using a CAD-CAM milling system produced superior fitting surface accuracy compared to the 3D-printing and injection-molded techniques. Full article
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14 pages, 285 KB  
Review
Oral Health and Older Adults: A Narrative Review
by Martin S. Lipsky, Tejasvi Singh, Golnoush Zakeri and Man Hung
Dent. J. 2024, 12(2), 30; https://doi.org/10.3390/dj12020030 - 1 Feb 2024
Cited by 47 | Viewed by 13939
Abstract
Oral health’s association with general health, morbidity, and mortality in older adults highlights its importance for healthy aging. Poor oral health is not an inevitable consequence of aging, and a proactive, multidisciplinary approach to early recognition and treatment of common pathologies increases the [...] Read more.
Oral health’s association with general health, morbidity, and mortality in older adults highlights its importance for healthy aging. Poor oral health is not an inevitable consequence of aging, and a proactive, multidisciplinary approach to early recognition and treatment of common pathologies increases the likelihood of maintaining good oral health. Some individuals may not have regular access to a dentist, and opportunities to improve oral health may be lost if health professionals fail to appreciate the importance of oral health on overall well-being and quality of life. The authors of this narrative review examined government websites, the American Dental Association Aging and Dental Health website, and the Healthy People 2030 oral objectives and identified xerostomia, edentulism, caries, periodontitis, and oral cancer as five key topics for the non-dental provider. These conditions are associated with nutritional deficiencies, poorer quality of life, increased risk of disease development and poorer outcomes for cardiovascular disease, diabetes, and other systemic conditions prevalent among older adults. It is important to note that there is a bi-directional dimension to oral health and chronic diseases, underscoring the value of a multidisciplinary approach to maintaining oral health in older adults. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry)
25 pages, 891 KB  
Systematic Review
Exploring the Risk Factors for Oral Cancer in Pakistan: A Systematic Literature Review
by Muhammad Feroz Khan, Richard P. Hayhoe and Russell Kabir
Dent. J. 2024, 12(2), 25; https://doi.org/10.3390/dj12020025 - 29 Jan 2024
Cited by 10 | Viewed by 7744
Abstract
Background: Oral cancer is one of the major public health issues in Pakistan and is the second most common malignancy in the country. This is mainly attributed to the widespread use of smokeless tobacco products, cigarettes, and paan without tobacco. This review aims [...] Read more.
Background: Oral cancer is one of the major public health issues in Pakistan and is the second most common malignancy in the country. This is mainly attributed to the widespread use of smokeless tobacco products, cigarettes, and paan without tobacco. This review aims to go beyond commonly discussed factors and, consequently, to provide a comprehensive picture of all the multi-faceted contributors to the high prevalence of the carcinoma of the oral cavity, including the role of human papillomavirus and genetic predisposition. The aim is to synthesise all available evidence on the predisposing factors of oral carcinoma in Pakistan. Methods: This is a comprehensive systematic review of all observational studies investigating the contributing factors of malignancy of the oral cavity in Pakistan, and it strictly follows the PRISMA guidelines. Multiple databases, such as PubMed, EBSCO CINAHL Plus, SCOPUS, and Ovid Medline, were used to find studies, and the Cochrane Database of Systematic Reviews was searched for existing/ongoing reviews carried out on the same topic. A meta-synthesis of selected studies was carried out to create robust and statistically valid conclusions. Results: ST and cigarette smoking were found to be the major contributors to the burden of carcinoma of the lip and oral cavity. The included studies indicated that genetic predisposition and human papillomavirus could be major risk factors for the disease in the Pakistani population, but not enough research has been carried out to find their true impact. Conclusions: Smokeless tobacco, cigarette smoking, genetic predisposition, and human papillomavirus can be considered significant risk factors for oral cancer in Pakistan. Full article
(This article belongs to the Special Issue Dental Oncology)
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13 pages, 1994 KB  
Article
Visual Versus Digital Color Determination of 3D-Printed Teeth as an Exercise in Dental Students’ Education
by Elisabeth Prause, Wolfgang B. Hannak, Robert Nicic, Holger A. Jakstat, Klaus Böning and Thomas Klinke
Dent. J. 2024, 12(2), 24; https://doi.org/10.3390/dj12020024 - 26 Jan 2024
Cited by 5 | Viewed by 3272
Abstract
Visual color determination is part of the daily routine in dental practice. However, it is not a part of dental education so far. The aim of this study was to evaluate whether visual or digital tooth color determination of 3D-printed teeth is a [...] Read more.
Visual color determination is part of the daily routine in dental practice. However, it is not a part of dental education so far. The aim of this study was to evaluate whether visual or digital tooth color determination of 3D-printed teeth is a reliable tool for inexperienced dentistry students. Preclinical dental students evaluated eleven 3D-printed, tooth-shaped samples (VarseoSmile Crown plus, BEGO, Bremen, Germany) of different color shades. Visual shade determination using a reference scale (3D-Master Toothguide (3DM_TG), VITA Zahnfabrik, Bad Säckingen, Germany), followed by a digital color determination using a spectrophotometer (VITA Easyshade V, (ES_V), VITA Zahnfabrik), was performed. Color deviation was calculated in the Lab* color space (ΔE00) and converted into CIELAB 2000. The results were evaluated using the Mann–Whitney U test and the Wilcoxon Rank Sum test (α = 0.05). Significant differences between visual and digital color determination were proven (p < 0.001). Visual color determination (3DM_TG) showed a mean deviation (ΔE00 ± 95%CI) of 6.49 ± 0.47. Digital color determination (ES_V) showed significantly lower mean deviations of ΔE00 of 1.44 ± 0.58. Digital tooth color measurement using a spectrophotometer was a more reliable tool for the color determination of 3D-printed teeth for inexperienced dentistry students. Full article
(This article belongs to the Special Issue New Trends in Dental Education and Dental Care)
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15 pages, 841 KB  
Systematic Review
Mouth Breathing and Its Impact on Atypical Swallowing: A Systematic Review and Meta-Analysis
by Carmen Gómez-González, Antonio González-Mosquera, Mohammad Hamdan Alkhraisat and Eduardo Anitua
Dent. J. 2024, 12(2), 21; https://doi.org/10.3390/dj12020021 - 23 Jan 2024
Cited by 7 | Viewed by 12159
Abstract
The aim of this systematic review is the assessment of the effect of mouth breathing on the prevalence of tongue thrust. The review was performed according to the PRISMA 2020 checklist guidelines, and the protocol was registered with PROSPERO (CRD42022339527). The inclusion criteria [...] Read more.
The aim of this systematic review is the assessment of the effect of mouth breathing on the prevalence of tongue thrust. The review was performed according to the PRISMA 2020 checklist guidelines, and the protocol was registered with PROSPERO (CRD42022339527). The inclusion criteria were the following: studies of clinical trials and cross-sectional and longitudinal descriptive studies that evaluate the appearance of tongue thrust in patients with mouth breathing; healthy subjects of any age, race or sex; and studies with a minimum sample group of five cases. The exclusion criteria were the following: studies with syndromic patients, articles from case reports, and letters to the editor and/or publisher. Searches were performed in electronic databases such as The National Library of Medicine (MEDLINE via PUBMED), the Cochrane Central Register of Controlled Trials, Web of Science and Scopus, including studies published until November 2023, without a language filter. The methodological quality of the included case–control studies was assessed using the Newcastle–Ottawa Scale (NOS), and the Joanna Briggs Institute (JBI) tool was used for descriptive cross-sectional studies and cross-sectional prevalence studies. A meta-analysis was conducted on studies that provided data on patients’ classification according to mouth breathing (yes/no) as well as atypical swallowing (yes/no) using Review Manager 5.4. From 424 records, 12 articles were selected, and 4 were eligible for meta-analysis. It was shown that there is no consensus on the diagnostic methods used for mouth breathing and tongue thrust. The pooled risk ratio of atypical swallowing was significantly higher in the patients with mouth breathing (RR: 3.70; 95% CI: 2.06 to 6.66). These studies have several limitations, such as the heterogeneity among the individual studies in relation to the diagnostic tools and criteria for the assessment of mouth breathing and atypical swallowing. Considering the results, this systematic review shows that patients with mouth breathing presented higher risk ratios for atypical swallowing. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry)
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12 pages, 5030 KB  
Article
Fracture Resistance of Repaired 5Y-PSZ Zirconia Crowns after Endodontic Access
by Andreas Greuling, Mira Wiemken, Christoph Kahra, Hans Jürgen Maier and Michael Eisenburger
Dent. J. 2023, 11(3), 76; https://doi.org/10.3390/dj11030076 - 7 Mar 2023
Cited by 8 | Viewed by 4152
Abstract
This study analyzed the fracture load before and after a chewing simulation of zirconia crowns that were trepanned and repaired using composite resin. Overall, 3 groups with 15 5Y-PSZ crowns in each group were tested. For group A, the fracture load of the [...] Read more.
This study analyzed the fracture load before and after a chewing simulation of zirconia crowns that were trepanned and repaired using composite resin. Overall, 3 groups with 15 5Y-PSZ crowns in each group were tested. For group A, the fracture load of the unmodified crowns was evaluated. For group B, the crowns were trepanned and repaired using composite resin, also followed by a fracture test. For group C, crowns were prepared like in group B but received thermomechanical cycling before the final fracture tests. Furthermore, scanning electron microscopy (SEM) and X-ray microscopy (XRM) analysis were performed for group C. The mean fracture loads and standard deviation were 2260 N ± 410 N (group A), 1720 N ± 380 N (group B), and 1540 N ± 280 N (group C). Tukey-Kramer multiple comparisons showed a significant difference between groups A and B (p < 0.01) and groups A and C (p < 0.01). After ageing, surface fissures were detected via SEM, but no cracks that reached from the occlusal to the inner side of the crown were detected via XRM. Within the limitations of this study, it can be stated that trepanned and composite-repaired 5Y-PSZ crowns show lower fracture loads than 5Y-PSZ crowns without trepanation. Full article
(This article belongs to the Topic Material Science in Endodontics)
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18 pages, 1731 KB  
Systematic Review
Immunomodulatory Effects of Endodontic Sealers: A Systematic Review
by Jindong Guo, Ove A. Peters and Sepanta Hosseinpour
Dent. J. 2023, 11(2), 54; https://doi.org/10.3390/dj11020054 - 17 Feb 2023
Cited by 18 | Viewed by 4281
Abstract
Inflammation is a crucial step prior to healing, and the regulatory effects of endodontic materials on the immune response can influence tissue repair. This review aimed to answer whether endodontic sealers can modulate the immune cells and inflammation. An electronic search in Scopus, [...] Read more.
Inflammation is a crucial step prior to healing, and the regulatory effects of endodontic materials on the immune response can influence tissue repair. This review aimed to answer whether endodontic sealers can modulate the immune cells and inflammation. An electronic search in Scopus, Web of Science, PubMed, and Google Scholar databases were performed. This systematic review was mainly based on PRISMA guidelines, and the risk of bias was evaluated by SYRCLEs and the Modified CONSORT checklist for in vivo and in vitro studies, respectively. In total, 28 articles: 22 in vitro studies, and six in vivo studies were included in this systematic review. AH Plus and AH 26 can down-regulate iNOS mRNA, while S-PRG sealers can down-regulate p65 of NF-κB pathways to inhibit the production of TNF-α, IL-1, and IL-6. In vitro and in vivo studies suggested that various endodontic sealers exhibited immunomodulatory impact in macrophages polarization and inflammatory cytokine production, which could promote healing, tissue repair, and inhibit inflammation. Since the paradigm change from immune inert biomaterials to bioactive materials, endodontic materials, particularly sealers, are required to have modulatory effects in clinical conditions. New generations of endodontic sealers could hamper detrimental inflammatory responses and maintain periodontal tissue, which represent a breakthrough in biocompatibility and functionality of endodontic biomaterials. Full article
(This article belongs to the Special Issue Regenerative Approaches in Dental Sciences)
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18 pages, 1784 KB  
Review
Systematic Review and Meta Analysis of the Relative Effect on Plaque Index among Pediatric Patients Using Powered (Electric) versus Manual Toothbrushes
by Andrew Graves, Troy Grahl, Mark Keiserman and Karl Kingsley
Dent. J. 2023, 11(2), 46; https://doi.org/10.3390/dj11020046 - 9 Feb 2023
Cited by 17 | Viewed by 14409
Abstract
Although many randomized controlled trials (RCT) have evaluated the efficacy of powered or electric toothbrushes compared with manual or traditional toothbrushes to remove biofilm and plaque, only one systematic review has been published for pediatric patients. The primary objective of this study was [...] Read more.
Although many randomized controlled trials (RCT) have evaluated the efficacy of powered or electric toothbrushes compared with manual or traditional toothbrushes to remove biofilm and plaque, only one systematic review has been published for pediatric patients. The primary objective of this study was to perform a systematic review and meta analysis for this population. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol, N = 321 studies were initially identified. Three independent, blinded abstract reviews were completed resulting in a total of n = 38/322 or 11.8% for the final analysis (n = 27 non-orthodontic, n = 11 orthodontic studies). Meta analysis of these outcome data have revealed a strong reduction in plaque index scores among pediatric patients using electric toothbrushes of approximately 17.2% for non-orthodontic patients and 13.9% for orthodontic patients. These results provide strong clinical evidence for recommending electric toothbrushing to pediatric patients, as well as those patients undergoing orthodontic therapy and treatment. Full article
(This article belongs to the Special Issue Feature Review Papers in Dentistry)
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14 pages, 2072 KB  
Article
Retrospective Longitudinal Study on Changes in Atmospheric Pressure as a Predisposing Factor for Odontogenic Abscess Formation
by Marko Tarle, Arijan Zubović, Boris Kos, Marina Raguž and Ivica Lukšić
Dent. J. 2023, 11(2), 42; https://doi.org/10.3390/dj11020042 - 8 Feb 2023
Cited by 3 | Viewed by 3493
Abstract
In our retrospective longitudinal study based on the data from 292 patients, we wanted to investigate whether there was an association between weather conditions and the occurrence of odontogenic abscesses (OA) requiring hospitalization. In the adult group (249 patients), the incidence of severe [...] Read more.
In our retrospective longitudinal study based on the data from 292 patients, we wanted to investigate whether there was an association between weather conditions and the occurrence of odontogenic abscesses (OA) requiring hospitalization. In the adult group (249 patients), the incidence of severe OA was highest in winter (32.9%) during January (11.6%), with the most common localizations being the perimandibular (35.7%) and submandibular (23.3%) regions. We found that changes in mean daily atmospheric pressure five days before hospitalization showed a positive association with the occurrence of OA, especially pressure variations greater than 12 hPa. Atmospheric pressure changes two and five days before hospitalization were also found to be moderate predictors of complications during treatment. Antibiogram analysis revealed resistance of streptococci to clindamycin in 26.3%. In the pediatric group, OA were also most frequent in winter (30.2%), and the perimandibular region (37.2%) and the canine fossa (20.9%) were the most frequent abscess localizations, while an association with meteorological parameters was not demonstrated. Clinical experience teaches us that weather change influences the occurrence of severe OA requiring hospitalization, which we confirmed in this research. To our knowledge, our study is the first to provide a threshold and precise time frame for atmospheric pressure changes. Full article
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases: Volume II)
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37 pages, 2472 KB  
Review
Periodontal Management in Periodontally Healthy Orthodontic Patients with Fixed Appliances: An Umbrella Review of Self-Care Instructions and Evidence-Based Recommendations
by Federica Di Spirito, Alessandra Amato, Maria Pia Di Palo, Davide Cannatà, Francesco Giordano, Francesco D’Ambrosio and Stefano Martina
Dent. J. 2023, 11(2), 35; https://doi.org/10.3390/dj11020035 - 31 Jan 2023
Cited by 26 | Viewed by 4677
Abstract
The present umbrella review aimed to characterize periodontal self-care instructions, prescriptions, and motivational methods; evaluate the associated periodontal outcomes; and provide integrated, evidence-based recommendations for periodontal self-care in periodontally healthy orthodontic patients with fixed appliances. The presently applied study protocol was developed in [...] Read more.
The present umbrella review aimed to characterize periodontal self-care instructions, prescriptions, and motivational methods; evaluate the associated periodontal outcomes; and provide integrated, evidence-based recommendations for periodontal self-care in periodontally healthy orthodontic patients with fixed appliances. The presently applied study protocol was developed in advance, compliant with the PRISMA statement, and registered on PROSPERO (CRD42022367204). Systematic reviews published in English without date restrictions were electronically searched until 21 November 2022 across the PROSPERO Register and Cochrane Library, Web of Science (Core Collection), Scopus, and MED-LINE/PubMed databases. The study quality assessment was conducted through the AMSTAR 2 tool. Seventeen systematic reviews were included. Powered and manual toothbrushes showed no significant differences in biofilm accumulation, although some evidence revealed significant improvements in inflammatory, bleeding, and periodontal pocket depth values in the short term with powered toothbrushes. Chlorhexidine mouthwashes, but no gels, varnishes, or pastes, controlled better biofilm accumulation and gingival inflammation as adjuncts to toothbrushing, although only for a limited period. Organic products, such as aloe vera and chamomile, proved their antimicrobial properties, and herbal-based mouthwashes seemed comparable to CHX without its side effects. Motivational methods also showed beneficial effects on periodontal biofilm control and inflammation, while no evidence supported probiotics administration. Full article
(This article belongs to the Special Issue Advances in Periodontal and Peri-Implant Tissues Health Management)
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14 pages, 2479 KB  
Article
In Vitro Trueness and Precision of Intraoral Scanners in a Four-Implant Complete-Arch Model
by Dimitrios Spagopoulos, George Kaisarlis, Foteini Spagopoulou, Demetrios J. Halazonetis, Jan-Frederik Güth and Efstratios Papazoglou
Dent. J. 2023, 11(1), 27; https://doi.org/10.3390/dj11010027 - 12 Jan 2023
Cited by 9 | Viewed by 4813
Abstract
(1) Background: New intraoral (IOS) and laboratory scanners appear in the market and their trueness and precision have not been compared. (2) Methods: Seven IOS and two laboratory scanners were used to scan a mandibular edentulous model with four parallel internal hexagon implant [...] Read more.
(1) Background: New intraoral (IOS) and laboratory scanners appear in the market and their trueness and precision have not been compared. (2) Methods: Seven IOS and two laboratory scanners were used to scan a mandibular edentulous model with four parallel internal hexagon implant analogues and PEEK scan bodies. Digital models in Standard Tessellation Language (STL) were created. The master model with the scan bodies was scanned (×10) with a computerized numerical control 3D Coordinate Measuring Machine (CMM). The short (distances of adjacent scan posts) and long distances (distances of the scan posts with non-adjacent sites in the arch) among the centroids of the four analogues were calculated using CMM special software. Trueness (comparisons with the master model) and precision (intragroup comparisons) were statistically compared with ANOVA, chi-square and Tukey tests. (3) Results: Laboratory scanners had the best trueness and precision compared to all IOSs for long distances. Only iTero (Align Technologies Inc., Milpitas, CA, USA) had comparable trueness with one laboratory scanner in short and long distances. For short distances, CS3600 (Carestream Health, Inc., Rochester, NY, USA), Omnicam, Primescan (Sirona Dental Sys-tems GmbH, Bens-heim, Germany) and TRIOS 4 (3Shape A/S, Copen-hagen, Denmark) had similar trueness to one laboratory scanner. From those, only Omnicam and Primescan had similar precision as the same laboratory scanner. Most IOSs seem to work better for smaller distances and are less precise in cross-arch distances. (4) Conclusions: The laboratory scanners showed significantly higher trueness and precision than all IOSs tested for the long-distance group; for the short distance, some IOSs were not different in trueness and precision than the laboratory scanners. Full article
(This article belongs to the Special Issue Quality Assurance, Professionalism, and Sustainability in Dentistry after the COVID-19 Pandemic)
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11 pages, 2597 KB  
Article
Effect of Temporary Cement, Surface Pretreatment and Tooth Area on the Bond Strength of Adhesively Cemented Ceramic Overlays—An In Vitro Study
by Sanita Grinberga, Evaggelia Papia, Jolanta Aleksejuniene, Vita Zalite, Janis Locs and Una Soboleva
Dent. J. 2023, 11(1), 19; https://doi.org/10.3390/dj11010019 - 5 Jan 2023
Cited by 1 | Viewed by 3844
Abstract
Several viewpoints have been reported regarding the effect of temporary cements, different surface pretreatment protocols before adhesive cementation, and predictive factors. This in vitro study tested if temporary cement, pretreatment of the tooth surface, the size of enamel or dentine influence adhesive cementation [...] Read more.
Several viewpoints have been reported regarding the effect of temporary cements, different surface pretreatment protocols before adhesive cementation, and predictive factors. This in vitro study tested if temporary cement, pretreatment of the tooth surface, the size of enamel or dentine influence adhesive cementation to zirconia ceramics. Twenty premolars were prepared for determination of enamel and dentin area, bond strength test and failure analysis. The samples were divided into two groups: untreated prior adhesive cementation (n = 10) and with temporary cementation done, pretreated prior adhesive cementation (n = 10). Zirconia overlays (Katana Zirconia STML) were cemented on the grounded flat teeth surfaces using Panavia V5. An additional six premolars underwent dentine tubule analysis with SEM to detect temporary cement residues after temporary cementation on an untreated tooth surface (n = 3) and on a pretreated surface (n = 3). The independent sample t-test was used to compare the two groups and the means of the total tooth, dentin or enamel areas did not differ significantly between the untreated and pretreated specimens. The mean tensile bond strength was significantly (p = 0.005) higher in the pretreated specimens (337N) than in the untreated ones (204N). The overall multivariable linear regression model with three predictors (surface pre-treatment, enamel area and dentine area) was significant (p = 0.003), among which the size of enamel was the strongest predictor (β = 0.506; p = 0.049), followed by the pretreatment effect (β = 0.478; p = 0.001) and the size of dentin area (β = −0.105; p = 0.022). Full article
(This article belongs to the Section Dental Materials)
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13 pages, 4345 KB  
Case Report
Temporomandibular Joint Ankylosis in a Girl Child: Immunochemical Evaluation of Tissue Material Obtained from Repeated Arthroplasty Surgeries
by Nityanand Jain, Mara Pilmane, Andrejs Skagers, Shivani Jain and Pavlo Fedirko
Dent. J. 2023, 11(1), 16; https://doi.org/10.3390/dj11010016 - 3 Jan 2023
Cited by 1 | Viewed by 2678
Abstract
Temporomandibular joint ankylosis (TMJA) is a rare, but debilitating, condition that leads to TMJ joint hypomobility. Surgery is the mainstay for treatment, which is accompanied by rehabilitative and psychological support. Despite the advances in surgical techniques, the recurrence of TMJA post-surgery has been [...] Read more.
Temporomandibular joint ankylosis (TMJA) is a rare, but debilitating, condition that leads to TMJ joint hypomobility. Surgery is the mainstay for treatment, which is accompanied by rehabilitative and psychological support. Despite the advances in surgical techniques, the recurrence of TMJA post-surgery has been reported as a common complication. Therefore, it becomes essential to investigate and understand the histo-morpho-pathological processes governing these ankylotic changes. Given the lack of such studies in the literature, herein we present a case of a girl child who underwent primary surgery at the age of six years, followed by a second surgery at the age of twelve years. Ankylotic tissue samples collected during both surgeries were studied using various immunohistochemical markers for tissue remodeling, inflammation, antimicrobial activity, and transcriptional regulation. The expression of MMP-2 and -9 was downregulated in repeated surgery materials, whilst MMP-13 was rarely detected in both tissues. Strong MMP-8, TIMP-2, and TIMP-4 expressions were noted in both tissues, showing their anti-inflammatory and protective roles. Moderately strong expression of bFGF, FGFR-1, IL-1α, and TNF-α could indicate sustained tissue growth in the background of inflammation (wound healing). Interestingly, the expression of β-defensin-2 was found to be constant in both tissues, thereby indicating possible ECM remodeling and collagen breakdown. Finally, a moderate expression of RUNX-2, coupled with a low expression of WNT-1 and -3a, could indicate a slow and delayed bone regeneration process. Our results showcase the complex myriad of pathways that could be involved in the progression of TMJA and post-surgery healing processes. Immunopathological studies could aid in improving the diagnosis, treatment, and prognosis for patients affected with TMJA. Full article
(This article belongs to the Special Issue Oral Health Care in Paediatric Dentistry Volume 2)
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15 pages, 1808 KB  
Article
The Effect of General Bone Mineral Density on the Quantity and Quality of the Edentulous Mandible: A Cross-Sectional Clinical Study
by Anda Slaidina, Baiba Springe, Andris Abeltins, Sergio E. Uribe and Aivars Lejnieks
Dent. J. 2023, 11(1), 17; https://doi.org/10.3390/dj11010017 - 3 Jan 2023
Cited by 10 | Viewed by 5086
Abstract
Background: Osteoporosis is a disease which is characterized by a decrease in general bone mineral density (BMD), resulting in decreased bone strength and an increased risk of bone fractures. The effect of reduced BMD on the jawbones is still not fully understood. The [...] Read more.
Background: Osteoporosis is a disease which is characterized by a decrease in general bone mineral density (BMD), resulting in decreased bone strength and an increased risk of bone fractures. The effect of reduced BMD on the jawbones is still not fully understood. The purpose of the study was to evaluate the impact of BMD on the quality and quantity of the edentulous mandible. Methods: The present study included 127 edentulous postmenopausal women who underwent cone beam computed tomography (CBCT) examinations. BMD measurements of the lumbar spine and femoral necks were performed by dual-energy X-ray absorptiometry. In the cross-sectional CBCT images, three different areas of the mandible (lateral incisor, first premolar, and first molar) were selected. The complete mandibular, trabecular, and cortical bone volumes were measured. All measurements were performed on the total mandibular area, and the basal and alveolar parts of the mandible. Results: The volume of the cortical bone was reduced for females with reduced BMD in the lateral incisor and first premolar regions, both in the total mandibular area and in the basal part of the mandible. The trabecular bone volume statistically significantly increased when the BMD decreased in the complete mandibular area and the basal part of the mandible (linear regression). The total bone volume significantly decreased with a decrease in BMD in the basal part of the mandible. Conclusions: Reduced BMD has a negative effect on the quantity and quality of bone in the basal part of the edentulous mandible. Full article
(This article belongs to the Topic Diagnostic Imaging in Oral and Maxillofacial Diseases)
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14 pages, 2470 KB  
Article
Implementation of a Full Digital Workflow by 3D Printing Intraoral Splints Used in Dental Education: An Exploratory Observational Study with Respect to Students’ Experiences
by Pablo Kraemer-Fernandez, Sebastian Spintzyk, Ebru Wahl, Fabian Huettig and Andrea Klink
Dent. J. 2023, 11(1), 5; https://doi.org/10.3390/dj11010005 - 26 Dec 2022
Cited by 8 | Viewed by 8032
Abstract
Fully digital workflows gained acceptance in dental practice and thereby are of interest for undergraduate education. An exploratory clinical observation was designed to track the implementation of such a workflow with novice digital users in order to describe its feasibility, time investment, and [...] Read more.
Fully digital workflows gained acceptance in dental practice and thereby are of interest for undergraduate education. An exploratory clinical observation was designed to track the implementation of such a workflow with novice digital users in order to describe its feasibility, time investment, and pitfalls. Methods: Students were invited to provide feedback for their experiences with a training module that consisted of the following: intraoral scanning, computer-aided design (CAD), manual finishing, and insertion of a 3D-printed bite splint for the lower jaw. Results: A total of 82 fourth-year students participated in the module. The average time required to perform an intraoral scan was 17 m 5 s, and all students were able to design a splint with an average time of 2 h 38 m. Students who indicated prior experience with CAD seem to outperform inexperienced students in both CAD task completion and intraoral scanning. The initial fit was reported as clinically acceptable by 68.5% of the participants, while 79% rated the workflow as very good to satisfactory and indicated that the training was helpful for dental practice. Conclusions: The implementation of a digital workflow in undergraduate dental education is feasible and has acceptable clinical results. However, CAD is time-intensive, and the experience can be challenging. Full article
(This article belongs to the Special Issue New Trends in Dental Education and Dental Care)
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13 pages, 1417 KB  
Article
An In Vivo Study on the Development of Bacterial Microbiome on Clear Orthodontic Retainer
by Kabilan Velliyagounder, Anil Ardeshna and Serena Shah
Dent. J. 2022, 10(12), 239; https://doi.org/10.3390/dj10120239 - 16 Dec 2022
Cited by 3 | Viewed by 3687
Abstract
Objectives: The objective of this study was to see how the bacterial composition changes on clear orthodontic retainer over a 14-day period. Methods: Saliva and plaque samples collected from a clear retainer surface were obtained from five healthy volunteers receiving retainer treatment. Prior [...] Read more.
Objectives: The objective of this study was to see how the bacterial composition changes on clear orthodontic retainer over a 14-day period. Methods: Saliva and plaque samples collected from a clear retainer surface were obtained from five healthy volunteers receiving retainer treatment. Prior to clear retainer delivery, patients had not been wearing any other appliances. Patients were instructed to wear their clear retainer for the 14-day period, taking them off to eat and to clean them with a soft-bristle toothbrush. The bacterial composition was determined via Illumina MiSeq sequencing of the bacterial 16S rRNA. After bioinformatics processing using the QIIME pipeline, the intra- and intergroup biodiversity of the sample was analyzed. Results: The bacterial composition changed over a 14-day period in the saliva and on the clear retainer. When comparing the different phylum levels between saliva and clear retainer’ microbiota, the Firmicutes were significantly increased 1.26-fold (p = 0.0194) and 1.34-fold (p = 0.0123) after 7 and 14 days of retainer treatment when compared to saliva, respectively. The Campylobacteriota were significantly decreased 1.80-fold (p = 0.05) in the clear retainer when compared to saliva at 7 days. At the genus level, several microbiota were significantly increased in relative abundance in the clear retainer after the 14-day period. Conclusion: These findings reveal that the presence of a clear retainer in the mouth might lead to enamel changes or periodontal tissue destruction, especially after 14 days of use. Full article
(This article belongs to the Special Issue Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their Impact on the Development of Dental Material)
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12 pages, 291 KB  
Article
Increased Oral Dryness and Negative Oral Health-Related Quality of Life in Older People with Overweight or Obesity
by Nattapat Khongsirisombat, Sirichai Kiattavorncharoen and Supanee Thanakun
Dent. J. 2022, 10(12), 231; https://doi.org/10.3390/dj10120231 - 6 Dec 2022
Cited by 7 | Viewed by 3555
Abstract
This cross-sectional study was to evaluate the association between the oral health-related quality of life (OHRQoL) of older Thai people with obesity and oral health indicators. General and oral conditions were assessed. Oral dryness was determined using the Xerostomia Inventory-11 (XI-11) and clinical [...] Read more.
This cross-sectional study was to evaluate the association between the oral health-related quality of life (OHRQoL) of older Thai people with obesity and oral health indicators. General and oral conditions were assessed. Oral dryness was determined using the Xerostomia Inventory-11 (XI-11) and clinical oral dryness score (CODS). OHRQoL was evaluated by the oral health impact profile (OHIP-14). Participants were aged 60–86 years; 73 (59.3%) were overweight or obese, and 50 (40.7%) were normal weight. Older patients with obesity had almost four times the rate of hypertension (OR = 3.59; 95%CI:1.34–9.60; p = 0.002), more missing teeth (p = 0.025), and higher CODS (p = 0.014) than those without obesity. The total XI-11 scores were positively associated with the total CODS, after adjusting for BMI (r = 0.267, p = 0.003). Those with obesity had almost three times the tendency for a negative OHRQoL compared with the non-obese (OR = 2.73; 95%CI:1.12–6.71; p = 0.04). After adjusting for all related factors, the chances of predicting an OHIP-14 score of four based on obesity and total XI-11 score were 4.42 (95%CI:1.57–12.47; p = 0.005) and 1.11 (95%CI:1.02–1.20; p = 0.013), respectively. Obesity had an increasingly undesirable negative impact on the OHRQoL of older Thai people and was influenced by BMI and oral dryness. Full article
(This article belongs to the Topic Oral Health Management for Children, Adolescents, and Adults)
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13 pages, 47145 KB  
Project Report
Streptococcus mutans Proteases Degrade Dentinal Collagen
by Bo Huang, Cameron A. Stewart, Christopher A. McCulloch, J. Paul Santerre, Dennis G. Cvitkovitch and Yoav Finer
Dent. J. 2022, 10(12), 223; https://doi.org/10.3390/dj10120223 - 28 Nov 2022
Cited by 15 | Viewed by 9682
Abstract
Here, we explored the role of S. mutans’s whole cell and discrete fractions in the degradation of type I collagen and dentinal collagen. Type I collagen gels and human demineralized dentin slabs (DS) were incubated in media alone or with one of [...] Read more.
Here, we explored the role of S. mutans’s whole cell and discrete fractions in the degradation of type I collagen and dentinal collagen. Type I collagen gels and human demineralized dentin slabs (DS) were incubated in media alone or with one of the following: overnight (O/N) or newly inoculated (NEW) cultures of S. mutans UA159; intracellular proteins, supernatant or bacterial membranes of O/N cultures. Media from all groups were analyzed for protease-mediated release of the collagen-specific imino acid hydroxyproline. Images of type I collagen and DS were analyzed, respectively. Type I collagen degradation was highest for the supernatant (p < 0.05) fractions, followed by intracellular components and O/N cultures. Collagen degradation for DS samples was highest for O/N samples, followed by supernatant, and intracellular components (p < 0.05). There was lower detectable degradation for both type I collagen and DS from NEW culture samples (p < 0.05), and there was no type I collagen or DS degradation detected for bacterial membrane samples. Structural changes to type I collagen gel and dentinal collagen were observed, respectively, following incubation with S. mutans cultures (O/N and NEW), intracellular components, and supernatant. This study demonstrates that intracellular and extracellular proteolytic activities from S. mutans enable this cariogenic bacterium to degrade type I and dentinal collagen in a growth-phase dependent manner, potentially contributing to the progression of dental caries. Full article
(This article belongs to the Special Issue Considering Host-Biomaterials and Microbial Interactions in Oral Health and Their Impact on the Development of Dental Material)
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10 pages, 571 KB  
Systematic Review
Effect of Photobiomodulation on Atrophic–Erosive Clinical Forms of Oral Lichen Planus: A Systematic Review
by Juan Antonio Ruiz Roca, Pía López Jornet, Francisco José Gómez García and Paula Marcos Aroca
Dent. J. 2022, 10(12), 221; https://doi.org/10.3390/dj10120221 - 27 Nov 2022
Cited by 14 | Viewed by 3671
Abstract
Introduction. Oral lichen planus is a chronic autoimmune inflammatory disease of unknown origin, characterized by various clinical forms of which the atrophic–erosive causes patients the greatest symptomatology. For this reason, there are different treatments that improve the associated signs and symptoms. One of [...] Read more.
Introduction. Oral lichen planus is a chronic autoimmune inflammatory disease of unknown origin, characterized by various clinical forms of which the atrophic–erosive causes patients the greatest symptomatology. For this reason, there are different treatments that improve the associated signs and symptoms. One of these therapies is photobiomodulation (PBM), which, although new, has a high level of acceptance in dentistry based on evidence. However, there are inconsistent results in its application against lichen planus. The aim of this review was to evaluate the effect of photobiomodulation and its effectiveness as a therapeutic alternative for atrophic–erosive lesions. Material and methods. The databases PubMed, Google Scholar and Cochrane Library were searched to identify studies investigating the photobiomodulation treatment in atrophic–erosive lesions of oral lichen planus. A total of 294 articles were identified, published between 2017 and 2022, and then evaluated; 7 articles that met all the inclusion criteria were included in this study. Results. The type of laser light source used in PBM was the diode laser (four cases), the Nd–YAG laser at the same wavelength of 1064 nm (two cases) and the He–Ne laser (one case). The minimum and maximum wavelengths used were 630 nm and 1064 nm, respectively. Most studies used lesions treated with topical corticosteroids as a control group. The follow-up times of the studies were highly variable. Conclusions. Photobiomodulation is a treatment that competently combats oral lichen planus lesions by improving signs and symptoms, with no known adverse reactions so far, which makes it more beneficial compared to more conventional therapies, such as corticosteroids, for which side effects have been found. Full article
(This article belongs to the Special Issue Photobiomodulation and Its Application in Dentistry)
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8 pages, 6435 KB  
Article
Assessment of Occlusal Vertical Dimension Change in Mechanical and Virtual Articulation: A Pilot Study
by Yu-Chun Lin, Rebecca Scialabba, Jason D. Lee, Jie Sun and Sang J. Lee
Dent. J. 2022, 10(11), 212; https://doi.org/10.3390/dj10110212 - 8 Nov 2022
Cited by 8 | Viewed by 7782
Abstract
The aim of this clinical study was to investigate the change in occlusal vertical dimension (OVD) with dental casts mounted on a mechanical articulator using an average axis facebow and on a virtual articulator mounted using the Bonwill triangle and the Balkwill angle [...] Read more.
The aim of this clinical study was to investigate the change in occlusal vertical dimension (OVD) with dental casts mounted on a mechanical articulator using an average axis facebow and on a virtual articulator mounted using the Bonwill triangle and the Balkwill angle and compare these groups with OVD change observed clinically in patients. Casts were obtained from each patient (n = 14) and mounted on a semi-adjustable articulator in the facebow preservation group (FPG) and on a virtual articulator using average anatomic values in the average mounting group (AMG). Customized mandibular anterior splints were virtually designed at an OVD increased by 3, 6, and 9 mm. Digital buccal scans were performed with the anterior devices in the participants’ mouths in the intraoral group (IOG), AMG, and FPG at the different OVD increases accordingly. While no statistically significant differences (p > 0.05) were observed in the posterior interocclusal measurements with the incisal guide pin raised by 3 mm and 6 mm among all groups, a 9 mm increase resulted in a significant difference between AMG and IOG. The interocclusal posterior-to-anterior opening ratio observed clinically was 1:1.575. Increases in OVD up to 6 mm on dental casts mounted using average anatomic values performed similarly to the actual intraoral changes. Full article
(This article belongs to the Special Issue Dentistry Journal: 10th Anniversary)
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11 pages, 1007 KB  
Article
Relationship between Children’s and Parents’ Dental Anxiety: A Cross-Sectional Study on the Six European Countries
by Luka Šimunović, Bruno Špiljak, Milica Radulović, Adna Vlahovljak, Mihailo Ostojić, Jovan Krlev, Amina Ibrahimpašić, Lara Vranić and Dubravka Negovetić Vranić
Dent. J. 2022, 10(11), 209; https://doi.org/10.3390/dj10110209 - 4 Nov 2022
Cited by 21 | Viewed by 6219
Abstract
Background: The purpose of this study is to investigate the relationship between children’s and parents’ dental anxiety. Methods: 731 children of different ages and their parents from six European countries participated in this study. Dental anxiety was investigated through an online questionnaire, which [...] Read more.
Background: The purpose of this study is to investigate the relationship between children’s and parents’ dental anxiety. Methods: 731 children of different ages and their parents from six European countries participated in this study. Dental anxiety was investigated through an online questionnaire, which consisted of general questions and the Corah Dental Anxiety Scale (CDAS), which is a questionnaire that measures respondents’ reactions on a 5-point scale for four different situations. Results: CDAS results were calculated for all children and their parents. A total of 12.5% of children from Croatia, 26.67% from Macedonia, 10.94% from Bosnia and Herzegovina, 20.31% from Montenegro, 23.08% from Slovenia and 16.10% from Serbia showed a high level of anxiety. The correlation between dental anxiety of parents and children was 0.4 (p < 0.01). Conclusions: Parents with negative experience from a dental office can have a bad effect on their child’s behaviour, which results in the creation of a non-active patient. Due to the clear and existing cause-and-effect relationship of dental anxiety in children and parents, it is extremely important to educate parents about the proper psychological approach to children in order to promote positive experiences from dental offices, as well as to emphasize the importance of regular visits to the dentist. Full article
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