Quality of Life in Surgical Oncology Patients

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Surgical Oncology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 741

Special Issue Editor


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Guest Editor
School of Medicine, Western Sydney University, Penrith, NSW 2751, Australia
Interests: upper GI surgery; pancreatic cancer; liver cancer; gastric cancer; value-based care

Special Issue Information

Dear Colleagues,

The treatment of patients with cancer is complex and multidisciplinary. We have always assumed that the role of all treatments is to cure the disease and return the patient to a normal lifestyle. In modern medical practice, this involves assessing not only survival and cures but balancing the impacts of these treatments, which often may be palliative or non-curative, on the overall quality of life of the patient and the wider ramifications on their family and carers. 

As the burden of cancer often falls on the older population, and as this population increases with life expectancy rates increasing worldwide, this Special Issue becomes even more important as we assess the impacts of aggressive treatments on a frailer population where issues, such as personal mobility, desires for independent living, and morbidity, associated with treatments need to be considered and assessed. To paraphrase Ivor Lewis when discussing some early treatments of oesophageal cancer: "We may or may not have prolonged their life: we certainly prolonged their misery”

As our abilities to treat and palliate tumours expand, we also need to expand beyond simple measures of just survival but take a more nuanced view and include in studies the overall impact of treatments on patients and their families, the ramifications on health resources and the health and community economic repercussions of treatments.

This Special Issue aims to present and discuss the issues of quality of life and surgical oncology. Contributions to be considered should cover this in the broader context of impacts not just on the patient but on the community and society.

Topics of interest will include, but not be limited to, the following:

  • Quality of life during and following treatment;
  • Impacts of treatments on the older population;
  • Impacts of technological improvements on treatments and quality of life;
  • Balancing cure and palliation with quality of life in different aged populations;
  • Moral dilemma associated with refusing and refusal of treatments in the older age groups;
  • Impacts of aggressive treatments on the health system in a financially constrained environment and the real opportunity costs to other patient cohorts;
  • Health equity and quality of life in the provision of treatments.

Dr. Neil Merrett
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PROMS
  • quality of life
  • health economics
  • surgical oncology
  • precision medicine
  • robotic surgery

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Published Papers (1 paper)

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Research

12 pages, 840 KB  
Article
Axillary Reverse Mapping Improves Quality of Life by Significantly Reducing Clinically Relevant Lymphedema After Axillary Lymph Node Dissection in Older Women with Breast Cancer
by Merve Tokocin, Turan Pehlivan and Atilla Celik
Curr. Oncol. 2026, 33(4), 212; https://doi.org/10.3390/curroncol33040212 - 10 Apr 2026
Viewed by 463
Abstract
Background: Breast cancer-related lymphedema (BCRL) is one of the most debilitating long-term morbidities after axillary lymph node dissection (ALND), severely impairing quality of life through reduced mobility, independence, and chronic burden, especially in older women. Axillary reverse mapping (ARM) aims to preserve upper [...] Read more.
Background: Breast cancer-related lymphedema (BCRL) is one of the most debilitating long-term morbidities after axillary lymph node dissection (ALND), severely impairing quality of life through reduced mobility, independence, and chronic burden, especially in older women. Axillary reverse mapping (ARM) aims to preserve upper extremity lymphatics while maintaining oncologic safety. Evidence in older adult populations with long-term follow-up remains limited. Methods: This retrospective cohort study included 138 female patients (median age 72.5 years) undergoing ALND for invasive breast cancer between January 2018 and January 2024. Patients were divided into ARM (n = 72) and non-ARM (n = 66) groups. BCRL was graded 0–3 according to adapted International Society of Lymphology (ISL) criteria (2013 consensus document). Assessments were performed preoperatively and at 3, 6, 12, 24, 36, 48, and 60 months using blinded circumference measurements and bioimpedance spectroscopy. Results: Baseline characteristics were comparable. Mean follow-up was 46.5 ± 8.8 months. Clinically relevant BCRL (Grades 2–3) was dramatically lower in the ARM group (18.1% vs. 60.6%, p < 0.0001), while subclinical changes (Grade 1) were similar (31.9% vs. 27.3%, p = 0.55). Kaplan–Meier analysis showed significantly better clinically relevant lymphedema-free survival with ARM (log-rank p = 0.00019), with curve separation after 30–40 months—indicating a sustained long-term benefit for quality of life in this frail population. Recurrence rates were comparable (8.3% vs. 10.6%, p = 0.776). Multivariable Cox regression confirmed ARM as an independent protective factor (adjusted HR 0.22, 95% CI 0.11–0.44, p < 0.0001). Conclusions: In older women with breast cancer, ARM significantly reduces clinically relevant lymphedema—a major determinant of long-term quality of life—without compromising oncologic safety. These findings support the routine consideration of ARM during ALND to preserve upper-extremity function, mobility, and independence in this vulnerable population, thereby balancing aggressive oncologic treatment with enhanced long-term quality of life and reduced treatment-related morbidity. Full article
(This article belongs to the Special Issue Quality of Life in Surgical Oncology Patients)
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