Special Issue "Melanogenesis and Melanin-Related Compounds: A Cosmetic Perspective"
A special issue of Cosmetics (ISSN 2079-9284).
Deadline for manuscript submissions: 31 May 2019
Dr. Lucia Panzella
Melanin pigments are one of the main determinants of skin and hair sensitivity to ultraviolet light and susceptibility to sun damage. Moreover, an overproduction or accumulation of melanins can lead to a local excess of pigmentation (hypermelanosis) associated with disorders such as melasma, lentigo, or postinflammatory hyperpigmentation, with a significant medical and aesthetic impact. Melanin pigments are produced in melanocytes by tyrosinase catalyzed oxidation of tyrosine, followed by a complex series of events that are regulated by either enzymatic or non-enzymatic factors. Recent advances in the chemistry of melanins have allowed one to disclose a number of important structure–property–function relationships that are of crucial relevance to the biological role of human pigments, including skin (photo) protection and UV-susceptibility. Two main groups of melanin pigments are found in humans: the black-to-dark brown eumelanins; and the lighter, yellowish-to-brown, sulfur-containing pheomelanins. The firsts are generated from the oxidative polymerization of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), derived from cyclization/oxidation of dopaquinone, whereas pheomelanins are produced when the addition of the thiol group of cysteine to dopaquinone occurs, leading to 5-S-cysteinyldopa as the major compound. Further oxidation of 5-S-cystenylopda leads to the formation of the pigments via benzothiazine intermediates. This Special Issue welcomes original research manuscripts on eumelanin and/or pheomelanin biosynthesis, which represent structures and properties of cosmetic relevance. Articles describing depigmenting activity (e.g., tyrosinase inhibition properties) of natural or synthetic compounds, as well as reviews describing the current state-of-the-art, are also welcome.
Dr. Lucia Panzella
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- depigmenting agents