Special Issue "Functional Polymers and Nanostructures: Coating Meets Biological Applications"

A special issue of Coatings (ISSN 2079-6412).

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editor

Prof. Giuseppe Cirillo
E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria
Tel. 0039 0984493011
Interests: cancer; infectious diseases; neurological diseases; nanoparticles; hydrogels; vesicles; hybrid materials; blood–brain barrier; transdermal delivery; nasal delivery
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Special Issue Information

Dear Colleagues,

Nanotechnology greatly impacts modern society by introducting different kinds of nanomaterials for applications in different technological fields, including chemistry, engineering, materials science, and nanomedicine. Different nanostructures have been proposed in the literature, including silica, carbon, and metal nanoparticles. Such nanostructures are often functionalized to improve their performances in taioloired applications. This Special Issue aims to be a platform for scientists working on polymer coating of nanostructures, sharing new insights in the employment of functional polymers for conferring specific biological activities to the resulting hybrid nanoscrtuctures.

In particular, the topics of interest include, but are not limited to:

• Covalent and non-covalent functionalization routes with macromolecules;
• Development of instrumental and functional characterization techniques;
• Innovative application opportunities;
• Key advantages and limitation in long-term use.

Dr. Giuseppe Cirillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle
Icariin-Functionalized Coating on TiO2 Nanotubes Surface to Improve Osteoblast Activity In Vitro and Osteogenesis Ability In Vivo
Coatings 2019, 9(5), 327; https://doi.org/10.3390/coatings9050327 - 18 May 2019
Cited by 1
Abstract
Surface modification of titanium is encouraged to facilitate early osseointegration in dental and orthopedic fields. Icariin is the main active constituents of Herba Epimedii, which has good bone-promoting ability. We established an icariin-functionalized coating composed of icariin and poly (lactic-co-glycolic acid) (PLGA) on [...] Read more.
Surface modification of titanium is encouraged to facilitate early osseointegration in dental and orthopedic fields. Icariin is the main active constituents of Herba Epimedii, which has good bone-promoting ability. We established an icariin-functionalized coating composed of icariin and poly (lactic-co-glycolic acid) (PLGA) on TiO2 nanotubes surface (NT-ICA-PLGA) to promote osteoblast cell activity and early osseointegration. Surface topography, wettability and drug release pattern of the established NT-ICA-PLGA surface were characterized by scanning electron microscopy (SEM), contact angle test and drug release test. MC3T3-E1 osteoblast cell activity tests were performed using SEM, immunofluorescent staining, cell counting kit-8 and alkaline phosphatase assays. The osteogenic effects of different surfaces were observed using a rat model. Surface characterization proved the successful fabrication of the icariin-functionalized coating on the TiO2 nanotube structure, with increased wettability. The NT-ICA-PLGA substrate showed sustained release of icariin until two weeks. Osteoblast cells grown on the NT-ICA-PLGA substrate displayed improved cell adhesion, proliferation and differentiation ability than the control Ti surface. The in vivo experiment also revealed superior bone forming ability on the NT-ICA-PLGA surface, compared to the pure Ti control. These results imply that the developed NT-ICA-PLGA substrate has a promising future use as functionalized coating for implant surface modification. Full article
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