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C
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Carbon Nanohybrids for Biomedical Applications (2nd Edition)
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Carbon Nanohybrids for Biomedical Applications (2nd Edition)

A special issue of C (ISSN 2311-5629). This special issue belongs to the section "Carbon Materials and Carbon Allotropes".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 2750

Special Issue Editor

Dr. Giuseppe Cirillo

E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: nanomaterials; biomaterials; carbon nanostructures; composite and hybrid materials; biomedical applications of functional materials; therapeutic devices; surface chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hybrid materials composed of organic and inorganic components are emerging as a class of biomaterials that can be extensively employed in biomedicine and various fields, including tissue engineering and drug delivery. The added value of such materials is the possibility of combining elements with various characteristics with materials possessing  superior properties, similar to some tissues within the human body. This Special Issue, entitled “Carbon Nanohybrids for Biomedical Applications (2nd Edition)”, aims to collect recent advances in the synthesis, modification, and characterization of hybrid materials based on carbon nanostructures in order to strengthen the impact of these materials in modern medicine. The 1st Edition of this Special Issue successfully published 20 papers, with more than 50,000 total views.

The aim of this Special Issue is to attract contributions (both research or review articles) that present multidisciplinary research involving chemists, materials scientists, biologists, engineers, and clinicians, and to act as a platform for knowledge exchange.

Dr. Giuseppe Cirillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. C is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon nanostructures
  • biomaterials
  • drug delivery
  • tissue engineering
  • nanoparticles
  • biosensors

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Related Special Issue

Published Papers (3 papers)

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Research

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17 pages, 2205 KiB  
Article
Exploring Metal Cluster Interactions with Functionalized Graphene via Molecular Dynamics Simulation
by Miriam Roldán-Matilla, Arisbel Cerpa-Naranjo and Isabel Lado-Touriño
C 2024, 10(4), 107; https://doi.org/10.3390/c10040107 - 18 Dec 2024
Viewed by 992
Abstract
This study investigates the interaction between copper (Cu) and silver (Ag) clusters and graphene-based materials using molecular dynamics simulations. It focuses on how graphene oxidation and aminated polyethylene glycol (PEG-NH2) functionalization influence interaction strength and cluster dynamics. The analysis includes pristine [...] Read more.
This study investigates the interaction between copper (Cu) and silver (Ag) clusters and graphene-based materials using molecular dynamics simulations. It focuses on how graphene oxidation and aminated polyethylene glycol (PEG-NH2) functionalization influence interaction strength and cluster dynamics. The analysis includes pristine graphene (PG), low-oxidized graphene oxide (GOL), and PEGylated graphene oxide (GO-PEG-NH2). The results reveal that clusters on PG exhibit high mobility, while GO-PEG-NH2 significantly restricts mobility due to strong interactions, as evidenced by highly negative interaction energies. GO-PEG-NH2 systems also display pronounced subdiffusive behavior (α < 1), indicating strong binding and constrained motion. These findings underscore the critical role of PEG-NH2 functionalization in controlling cluster diffusion, paving the way for innovative designs in biomedical and catalytic nanocarrier applications. Full article
(This article belongs to the Special Issue Carbon Nanohybrids for Biomedical Applications (2nd Edition))
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11 pages, 2993 KiB  
Article
Graphene Xerogel for Drug Release
by Kyriaki Kalyva, Katerina Michalarou, Moch Izzul Haq Al Maruf and Vasilios I. Georgakilas
C 2024, 10(4), 99; https://doi.org/10.3390/c10040099 - 28 Nov 2024
Cited by 1 | Viewed by 1031
Abstract
By functionalizing reduced graphene oxide with polydopamine, the production of a two-dimensional hydrophilicplatform with hydrophobic areas, suitable for the stabilization and slow and controlled release of hydrophilic and hydrophobic drugs, was realized. The functionalized graphene was first enriched with different organic drug molecules, [...] Read more.
By functionalizing reduced graphene oxide with polydopamine, the production of a two-dimensional hydrophilicplatform with hydrophobic areas, suitable for the stabilization and slow and controlled release of hydrophilic and hydrophobic drugs, was realized. The functionalized graphene was first enriched with different organic drug molecules, either hydrophilic, such as doxorubicin, or hydrophobic, such as curcumin or quercetin, and then incorporated into a xerogel of chitosan and polyvinyl alcohol. The graphene substrate stabilizes the xerogel in water and effectively controls the release of doxorubicin for more than three weeks. The release of curcumin and quercetin in the aqueous environment was equally successful but at different rates. The drug-loaded xerogels also worked effectively after their incorporation into a hemostatic cotton gauze. Full article
(This article belongs to the Special Issue Carbon Nanohybrids for Biomedical Applications (2nd Edition))
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Review

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47 pages, 2999 KiB  
Review
Advances in the Synthesis of Carbon Nanomaterials Towards Their Application in Biomedical Engineering and Medicine
by Numair Elahi and Constantinos D. Zeinalipour-Yazdi
C 2025, 11(2), 35; https://doi.org/10.3390/c11020035 - 20 May 2025
Abstract
Carbon nanomaterials that include different forms such as graphene, carbon nanotubes, fullerenes, graphite, nanodiamonds, carbon nanocones, amorphous carbon, as well as porous carbon, are quite distinguished by their unique structural, electrical, and mechanical properties. This plays a major role in making them pivotal [...] Read more.
Carbon nanomaterials that include different forms such as graphene, carbon nanotubes, fullerenes, graphite, nanodiamonds, carbon nanocones, amorphous carbon, as well as porous carbon, are quite distinguished by their unique structural, electrical, and mechanical properties. This plays a major role in making them pivotal in various medical applications. The synthesis methods used for such nanomaterials, including techniques such as chemical vapor deposition (CVD), arc discharge, laser ablation, and plasma-enhanced chemical vapor deposition (PECVD), are able to offer very precise control over material purity, particle size, and scalability, enabling for nanomaterials catered for different specific applications. These materials have been explored in a range of different systems, which include drug-delivery systems, biosensors, tissue engineering, as well as advanced imaging techniques such as MRI and fluorescence imaging. Recent advancements, including green synthesis strategies and novel innovative approaches like ultrasonic cavitation, have improved both the precision as well as the scalability of carbon nanomaterial production. Despite challenges like biocompatibility and environmental concerns, these nanomaterials hold immense promise in revolutionizing personalized medicine, diagnostics, and regenerative therapies. Many of these applications are currently positioned at Technology Readiness Levels (TRLs) 3–4, with some systems advancing toward preclinical validation, highlighting their emerging translational potential in clinical settings. This review is specific in evaluating synthesis techniques of different carbon nanomaterials and establishing their modified properties for use in biomedicine. It focuses on how these techniques establish biocompatibility, scalability, and performance for use in medicines such as drug delivery, imaging, and tissue engineering. The implications of nanostructure behavior in biological environments are further discussed, with emphasis on applications in imaging, drug delivery, and biosensing. Full article
(This article belongs to the Special Issue Carbon Nanohybrids for Biomedical Applications (2nd Edition))
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