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Recent Advances in Bioactive Coatings
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Recent Advances in Bioactive Coatings

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 20486

Special Issue Editor

Assoc. Prof. Camelia Ungureanu

E-Mail Website
Guest Editor
University Politehnica of Bucharest, Bucuresti, Romania
Interests: medical and pharmaceutical biotechnology; environmental biotechnology; biosynthesis; antimicrobial activity; modelling; antimicrobial coating
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The research for novel materials, which is focused on bioactivity and biocompatibility of the compound as well as their mechanical properties, is a very topical issue. Bioactive coatings, in particular, is a topic of research that has experienced an exponential increase in interest in the last decade. Efforts to improve the bioactivity of materials and increase their surface area is currently being studied, with some positive outcomes. Materials are being used as a coating and combined with further treatments and functional coatings which may reinforce their bioresponsive properties, providing additional properties, such as antimicrobial activity. The ideal material, based on our current needs, should be able to promote osteointegration and minimize bacterial adhesion.
Coatings consisting of extracellular matrix proteins, bioceramics or biological peptides bring bioactivity and biocompatibility to the implant surface, which promotes bone ingrowth. Furthermore, coatings such as antibiotics, silver, and peptides with antimicrobial properties have also been developed, showing promise in reducing bacterial adhesion.
This Special Issue, entitled “Recent Advances in Bioactive Coatings”, is dedicated to introducing recent advances in bioactive coatings. It is with great pleasure that I invite you to submit a manuscript for this Special Issue. Full papers, reviews, and communications are all welcome.

In particular, the topics of interest include but are not limited to:

  • Incorporation of a natural compound with an antimicrobial effect (e.g., fibroin; bioactive compounds obtaining by biotechnological production);
  • Incorporation of a natural extract.

Assoc. Prof. Camelia Ungureanu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (7 papers)

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Research

23 pages, 8354 KiB  
Article
Novel Ecogenic Plasmonic Biohybrids as Multifunctional Bioactive Coatings
by Marcela Elisabeta Barbinta-Patrascu, Camelia Ungureanu, Nicoleta Badea, Mihaela Bacalum, Andrada Lazea-Stoyanova, Irina Zgura, Catalin Negrila, Monica Enculescu and Cristian Burnei
Coatings 2020, 10(7), 659; https://doi.org/10.3390/coatings10070659 - 9 Jul 2020
Cited by 17 | Viewed by 2686
Abstract
The objective of the present study is the valorization of natural resources and the recycling of vegetal wastes by converting them into novel plasmonic bio-active hybrids. Thus, a “green” approach was used to design pectin-coated bio-nanosilver. Silver nanoparticles were generated from two common [...] Read more.
The objective of the present study is the valorization of natural resources and the recycling of vegetal wastes by converting them into novel plasmonic bio-active hybrids. Thus, a “green” approach was used to design pectin-coated bio-nanosilver. Silver nanoparticles were generated from two common garden herbs (Mentha piperita and Amaranthus retroflexus), and pectin was extracted from lemon peels. The samples were characterized by the following methods: Ultraviolet–visible (UV-Vis) absorption spectroscopy, Fourier Transform Infrared (FT-IR), X-ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), dynamic light scattering (DLS), Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM)–Energy-dispersive X-ray Spectroscopy (EDX), and zeta potential measurements. Microscopic investigations revealed the spherical shape and the nano-scale size of the prepared biohybrids. Their bioperformances were checked in terms of antioxidant and antibacterial activity. The developed plasmonic materials exhibited a strong ability to scavenge short-life (96.1% ÷ 98.7%) and long-life (39.1% ÷ 91%) free radicals. Microbiological analyses demonstrated an impressive antibacterial effectiveness of pectin-based hybrids against Escherichia coli. The results are promising, and the obtained biomaterials could be used in many bio-applications, especially as antioxidant and antimicrobial biocoatings. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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16 pages, 3309 KiB  
Article
Dual Nanofibrous Bioactive Coatings on TiZr Implants
by Mariana Prodana, Claudiu-Eduard Nistor, Andrei Bogdan Stoian, Daniela Ionita and Cristian Burnei
Coatings 2020, 10(6), 526; https://doi.org/10.3390/coatings10060526 - 29 May 2020
Cited by 11 | Viewed by 2281
Abstract
The objective of this research was to obtain a dual coating with antimicrobial properties on TiZr implants. The metallic surfaces were modified with two biopolymers (poly(lactic acid) and polycaprolactone), the first deposited by dip coating and the second by electrospinning, in order to [...] Read more.
The objective of this research was to obtain a dual coating with antimicrobial properties on TiZr implants. The metallic surfaces were modified with two biopolymers (poly(lactic acid) and polycaprolactone), the first deposited by dip coating and the second by electrospinning, in order to create a nanofibers type of coating with antibacterial and bioactive effect. The surface characteristics of the obtained bioactive coatings were evaluated by Fourier Transformed Infrared Spectroscopy, by scanning electron microscopy and by contact angle measurements. The electrochemical characterization of the coatings was performed in simulated body fluid. The metallic ion release from the coated implant materials was measured by inductively coupled plasma mass spectrometry. The in vitro antimicrobial properties of the coatings were studied using agar disc diffusion method and percentage inhibition of growth method for two bacterial strains—S. aureus and E. coli. The presence of silver nanoparticles presented high inhibition zone against gram negative bacteria like E. coli. Cell viability of MC3T3-E1 osteoblasts and cytoskeleton morphology, were tested in vitro for the biological evaluation. The results on in vitro cell response indicated good cell membrane integrity and viability for such nanofibrous bioactive coatings compared to the control substrate. These surface architectures design on implant materials holds promise for biomedical applications, presenting good antimicrobial properties and promote cell adhesion and proliferation. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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Graphical abstract

18 pages, 3962 KiB  
Article
Silk Fibroin-Based Hybrid Nanostructured Coatings for Titanium Implantable Surfaces Modification
by Simona Popescu, Maria-Elena Zarif, Cristina Dumitriu, Camelia Ungureanu and Cristian Pirvu
Coatings 2020, 10(6), 518; https://doi.org/10.3390/coatings10060518 - 28 May 2020
Cited by 12 | Viewed by 2969
Abstract
This study proposes the development of new architectures that combine nanostructured titanium surface and biodegradable polymers as a promising approach to achieve a better performance after bioactive agent incorporation. The silk fibroin protein that was extracted from silkworm Bombyx mori cocoons is important [...] Read more.
This study proposes the development of new architectures that combine nanostructured titanium surface and biodegradable polymers as a promising approach to achieve a better performance after bioactive agent incorporation. The silk fibroin protein that was extracted from silkworm Bombyx mori cocoons is important due to the remarkable characteristics, such as biocompatibility, good mechanical properties, adjustable degradation and drug stabilizing capabilities. The titanium substrate was firstly nanostructurated with TiO2 nanotubes and then coated with silk fibroin using electrospinning and electrochemical deposition. The deposited silk film ability to become a bioactive implant coating with antibacterial properties after the encapsulation of the active agents such as CeO2 was investigated. Important features of the new implant coating were analysed: surface properties, electrochemical stability in physiological simulated electrolytes, and antibacterial action against Escherichia coli. The obtained results indicate that silk fibroin bioactive layers are a potential candidate for regenerative medicine. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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15 pages, 3439 KiB  
Article
Dermal Targeting Delivery of Terbinafine Hydrochloride Using Novel Multi-Ethosomes: A New Approach to Fungal Infection Treatment
by Lijun Zhang, Xue Li, Shunyao Zhu, Ting Zhang, Aikebaier Maimaiti, Meihong Ding and Senlin Shi
Coatings 2020, 10(4), 304; https://doi.org/10.3390/coatings10040304 - 25 Mar 2020
Cited by 14 | Viewed by 3574
Abstract
This research aimed to develop and evaluate a novel multi-ethosome (ME) system for the dermal delivery of terbinafine hydrochloride (TH) as a new approach to fungal infection treatment. TH-loaded MEs were successfully prepared using cinnamaldehyde as a penetration enhancer. Mean diameter of ME [...] Read more.
This research aimed to develop and evaluate a novel multi-ethosome (ME) system for the dermal delivery of terbinafine hydrochloride (TH) as a new approach to fungal infection treatment. TH-loaded MEs were successfully prepared using cinnamaldehyde as a penetration enhancer. Mean diameter of ME was found as ~100 nm with monodispersed size distribution. Drug entrapment efficiency reached up to 86% ± 1.4%. MEs exhibited excellent colloid stability and no drug leakage after 2 months of storage. In contrast to a commercial Lamisil® cream, ME significantly improved the targeting efficiency by increasing the fluidity of stratum corneum layer, revealed by attenuated total reflection Fourier transformed infrared spectroscopy (ATR-FTIR). The dermal targeting effect was visualized using confocal microscopy. Moreover, skin irritation and allergy tests showed that ME was not irritating to the skin. The improved antifungal activity of ME was proved in vitro on Candida albicans strains by minimal inhibitory concentration (MIC) assay. This study paves the way towards design of MEs for dermal fungal infection treatment. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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12 pages, 3912 KiB  
Article
Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid
by Farzad Soleymani, Rahmatollah Emadi, Sorour Sadeghzade and Fariborz Tavangarian
Coatings 2020, 10(3), 231; https://doi.org/10.3390/coatings10030231 - 3 Mar 2020
Cited by 15 | Viewed by 2435
Abstract
Polymer–ceramic composite coatings on magnesium-based alloys have attracted lots of attention in recent years, to control the speed of degradability and to enhance bioactivity and biocompatibility. In this study, to decrease the corrosion rate in a simulated body fluid (SBF) solution for long [...] Read more.
Polymer–ceramic composite coatings on magnesium-based alloys have attracted lots of attention in recent years, to control the speed of degradability and to enhance bioactivity and biocompatibility. In this study, to decrease the corrosion rate in a simulated body fluid (SBF) solution for long periods, to control degradability, and to enhance bioactivity, polycaprolactone–chitosan composite coatings with different percentages of baghdadite (0 wt.%, 3 wt.%, and 5 wt.%) were applied to an anodized AZ91 alloy. According to the results of the immersion test of the composite coating containing 3 wt.% baghdadite in a phosphate buffer solution (PBS), the corrosion rate decreased from 0.45 (for the AZ91 sample) to 0.11 mg/cm2·h after seven days of immersion. To evaluate the apatite formation capability of specimens, samples were immersed in an SBF solution. The results showed that the samples were bioactive as apatite layers formed on the surface of specimens. The composite coating containing 3 wt.% baghdadite showed the highest apatite-formation capability, with a controlled release of ions, and the lowest corrosion rate in the SBF. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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15 pages, 12694 KiB  
Article
Uptake of Pb(II) Ions from Simulated Aqueous Solution via Nanochitosan
by Camellia Zareie, Saeideh Kholghi Eshkalak, Ghasem Najafpour Darzi, Mazyar Sharifzadeh Baei, Habibollah Younesi and Seeram Ramakrishna
Coatings 2019, 9(12), 862; https://doi.org/10.3390/coatings9120862 - 15 Dec 2019
Cited by 11 | Viewed by 2930
Abstract
In this work, nanochitosan (NC) was prepared through ionic gelation using low molecular weight chitosan and maleic acid (MA). The synthesized NC was characterized by atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). During preparation, the particle [...] Read more.
In this work, nanochitosan (NC) was prepared through ionic gelation using low molecular weight chitosan and maleic acid (MA). The synthesized NC was characterized by atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). During preparation, the particle size of the material depended on parameters such as concentration of chitosan and pH of the aqueous solution. After controlling the mentioned parameters, NC smaller than 100 nm was prepared. The chitosan and prepared NC were employed for the adsorption of Pb(II) from an aqueous solution in the form of a batch system. Among the sorption parameters, pH showed the strongest effect on the sorption process and removal of the maximum number of Pb(II) ions was obtained at pH value of 6. Pseudo-first-order and pseudo-second-order models were used to track the kinetics of the adsorption process. Langmuir and Freundlich’s isotherms were subjected to the absorption data to evaluate absorption capacity. NC proved to be an excellent adsorbent with a remarkable capacity to eliminate Pb(II) ions from aqueous solutions at multiple concentrations. The NC also showed better performance with a comparatively easier preparation process than in other reported work. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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14 pages, 9616 KiB  
Article
Applying Baghdadite/PCL/Chitosan Nanocomposite Coating on AZ91 Magnesium Alloy to Improve Corrosion Behavior, Bioactivity, and Biodegradability
by Farzad Soleymani, Rahmatollah Emadi, Sorour Sadeghzade and Fariborz Tavangarian
Coatings 2019, 9(12), 789; https://doi.org/10.3390/coatings9120789 - 25 Nov 2019
Cited by 25 | Viewed by 3028
Abstract
Magnesium alloys have received a great amount of attention regarding being used in biomedical applications; however, they show high degradability, poor bioactivity, and biocompatibility. To improve these properties, surface modification and various types of coatings have been applied. In this study, an anodized [...] Read more.
Magnesium alloys have received a great amount of attention regarding being used in biomedical applications; however, they show high degradability, poor bioactivity, and biocompatibility. To improve these properties, surface modification and various types of coatings have been applied. In this study, an anodized AZ91 alloy was coated with a polymer matrix composite made of polycaprolactone/chitosan (PCL/Ch) with different percentages of baghdadite to improve its resistance to corrosion, bioactivity, and biocompatibility. The effects of different percentages of baghdadite (0 wt %, 1 wt %, 3 wt %, and 5 wt %) on the surface microstructure, corrosion resistance, roughness, and wettability were evaluated. The results indicated that the applied nano-polymer-ceramic coating including 3 wt % baghdadite was hydrophobic, which consequently increased the corrosion resistance and decreased the corrosion current density of the anodized AZ91 alloy. Coating with 3 wt % baghdadite increased the roughness of AZ91 from 0.329 ± 0.02 to 7.026 ± 0.31 μm. After applying the polymer-ceramic coating on the surface of anodized AZ91, the corrosion products changed into calcium–phosphate compounds instead of Mg(OH)2, which is more stable in a physiological environment. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
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