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Advances in Functional Bio-Coatings
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Advances in Functional Bio-Coatings

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Bioactive Coatings and Biointerfaces".

Deadline for manuscript submissions: 22 February 2025 | Viewed by 7284

Special Issue Editors

Dr. Mosab Kaseem

E-Mail Website
Guest Editor
Department of Nanotechnology and Advanced Materials Engineering, Sejong University, Seoul 05006, Republic of Korea
Interests: corrosion matter of protective metallic materials via plasma electrolysis; surface modification via organic–inorganic conjugation; electrochemical interpretation per equivalent circuit model; plasticity control and mechanical modeling of nanostructured crystalline solid; biodegradable polymers; development of bioactive coatings on metallic materials
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Burak Dikici

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Ataturk University, Erzurum 25240, Turkey
Interests: manufacturing processes of bio-coatings; in vitro corrosion of biomaterials; biodegradable metallic materials; high-entropy alloy coatings; sol–gel; PVD/CVD-based coatings; bioceramic coatings; plasma electrolytic oxidation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bio-functional coatings have become the most efficient method for satisfying many therapeutic needs, in addition to producing excellent corrosion resistance and good mechanical qualities. For this Special Issue, we invite submissions exploring the latest advances in functional bio-coatings. In particular, the topics of interest include but are not limited to: manufacturing processes of bio-coatings, in vitro and in vivo responses of bio-coatings, the functionality of bio-coatings, biodegradable coatings, drug-delivery coatings, high-entropy alloy coatings, bioceramic coatings, cold spray deposition, thermal spray deposition, laser cladding technologies, sol–gel deposition, plasma electrolytic oxidation bio-coatings,  and PVD- and CVD-based bio-coatings. All manuscripts will be peer-reviewed, and those accepted will be immediately published online as a Special Issue entitled “Advances in Functional Bio-Coatings”. We welcome original research and review articles showcasing achievements and developments and providing guidance for developing functional bio-coatings.

Dr. Mosab Kaseem
Prof. Dr. Burak Dikici
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional bio-coatings
  • biomaterials
  • surface treatment
  • drug delivery
  • biocompatibility
  • corrosion
  • mechanical properties
  • antibacterial properties
  • cell viability

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Published Papers (6 papers)

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Research

20 pages, 18637 KiB  
Article
Poly(Lactide) Nonwoven Fabric with Iron Coating and Its Biological Properties
by Zdzisława Mrozińska, Małgorzata Świerczyńska, Michał Juszczak, Katarzyna Woźniak and Marcin H. Kudzin
Coatings 2024, 14(8), 1050; https://doi.org/10.3390/coatings14081050 - 16 Aug 2024
Viewed by 590
Abstract
The study investigated the biological properties of a composite material composed of poly(lactide) (PLA) and iron (Fe) produced by sputtering iron onto melt-blown poly(lactide) nonwoven fabrics. The research aimed to thoroughly understand the structure and properties of these materials and their potential applications [...] Read more.
The study investigated the biological properties of a composite material composed of poly(lactide) (PLA) and iron (Fe) produced by sputtering iron onto melt-blown poly(lactide) nonwoven fabrics. The research aimed to thoroughly understand the structure and properties of these materials and their potential applications in biomedicine. We conducted comprehensive chemical and structural analyses using techniques such as microscopic analysis, flame atomic absorption spectrometry (FAAS), and Brunauer–Emmett–Teller (BET) surface area analysis to precisely determine the properties of PLA-Fe materials. Additionally, we evaluated their impact on blood coagulation processes by measuring activated partial thromboplastin time (aPTT) and prothrombin time (PT). We also performed biological analyses on human peripheral blood mononuclear cells (PBM cells) including cell viability and DNA damage. Our results clearly demonstrate that PLA-Fe materials do not significantly influence blood coagulation mechanisms, as they only slightly prolong aPTT time and have no effect on PT. This suggests their potential in biomedical applications. Our results indicate the absence of cyto- and genotoxic properties of PLA-Fe materials against normal blood cells. In conclusion, the research findings suggest that the novel poly(lactide) and iron-sputtered nonwoven fabrics are promising tools in the field of biomedicine, offering potentially innovative therapeutic solutions for the treatment of wounds and injuries. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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20 pages, 7035 KiB  
Article
Biochemical and Microbiological Properties of the Cotton–Copper Composite Material Obtained via Sputter Deposition
by Małgorzata Świerczyńska, Zdzisława Mrozińska, Michał Juszczak, Katarzyna Woźniak and Marcin H. Kudzin
Coatings 2024, 14(7), 900; https://doi.org/10.3390/coatings14070900 - 18 Jul 2024
Viewed by 920
Abstract
This study investigated the biochemical and microbiological properties of Cotton–Copper composite materials obtained using magnetron sputtering technology. Copper particles were precisely distributed on the fabric surface, ensuring free airflow without the need to create additional layers. The Cotton–Copper composite materials were subjected to [...] Read more.
This study investigated the biochemical and microbiological properties of Cotton–Copper composite materials obtained using magnetron sputtering technology. Copper particles were precisely distributed on the fabric surface, ensuring free airflow without the need to create additional layers. The Cotton–Copper composite materials were subjected to physiochemical and biological investigations. The physiochemical analysis included the elemental analysis of composites (C, N, O, S, Cu) and analyses of their microscopic and surface properties (specific surface area and total pore volume). The biological investigations consisted of microbiological and biochemical–hematological tests, including evaluation of the activated partial thromboplastin time and prothrombin time. Experiments showed significant effectiveness of the antibacterial material against representative strains of fungi and bacterial species. We also demonstrated the ability of the cotton–copper material to interact directly with the plasmid DNA. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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19 pages, 29254 KiB  
Article
Biochemical Evaluation and Structural Characteristics of Copper Coating Cellulose Nonwovens Prepared by Magnetron Sputtering Technology
by Małgorzata Świerczyńska, Zdzisława Mrozińska, Agnieszka Lisiak-Kucińska, Anetta Walawska and Marcin H. Kudzin
Coatings 2024, 14(7), 843; https://doi.org/10.3390/coatings14070843 - 5 Jul 2024
Viewed by 644
Abstract
The research aimed to enhance the aqua-jet/spunlace cellulose nonwoven fabric by deposition of copper coating by magnetron sputtering technology. Plasma technology facilitated the efficient distribution of copper particles on the surface of the cellulose nonwoven fabric, while maintaining free airflow and eliminating the [...] Read more.
The research aimed to enhance the aqua-jet/spunlace cellulose nonwoven fabric by deposition of copper coating by magnetron sputtering technology. Plasma technology facilitated the efficient distribution of copper particles on the surface of the cellulose nonwoven fabric, while maintaining free airflow and eliminating the need for additional layers. New cellulose-copper composites exhibit potential in biomedical applications, while minimizing their impact on biological processes such as blood plasma coagulation. Consequently, they can be utilized in the production of dressings, bandages, and other medical products requiring effective protection against bacterial infections. The cellulose-copper composite material was subjected to the physiochemical and biological investigations. The physiochemical analysis included the elemental analysis of composites, their microscopic analysis and the surface properties analysis (specific surface area and total pore volume). The biological investigations consisted of biochemical-hematological tests including the evaluation of the activated partial thromboplastin time and pro-thrombin time. Biodegradable materials based on cellulose nonwoven fabrics with the addition of copper offer a promising alternative to conventional materials. Their innovative properties, coupled with environmental friendliness and minimal impact on biological processes, offer vast application possibilities in healthcare and the production of hygiene products. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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11 pages, 3091 KiB  
Communication
Expanding (Bio)Conjugation Strategies: Metal-Free Thiol-Yne Photo-Click Reaction for Immobilization onto PLLA Surfaces
by Julia Sánchez-Bodón, Maria Diaz-Galbarriatu, Leyre Pérez-Álvarez, José Luis Vilas-Vilela and Isabel Moreno-Benítez
Coatings 2024, 14(7), 839; https://doi.org/10.3390/coatings14070839 - 4 Jul 2024
Viewed by 800
Abstract
The study delves into the use of the thiol-yne click reaction to enhance (bio)conjugation methodologies, particularly focusing on immobilizing biomolecules onto PLLA surfaces. The thiol-yne click reaction, known for its efficiency, selectivity, and versatility in forming carbon-sulfur bonds under mild conditions without transition [...] Read more.
The study delves into the use of the thiol-yne click reaction to enhance (bio)conjugation methodologies, particularly focusing on immobilizing biomolecules onto PLLA surfaces. The thiol-yne click reaction, known for its efficiency, selectivity, and versatility in forming carbon-sulfur bonds under mild conditions without transition metal catalysts, is explored for conjugating the fluorophore dansyl onto PLLA surfaces. This approach aims to broaden bioconjugation strategies beyond traditional methods like the Michael-type reaction, expanding their applicability to diverse biomolecules. Utilizing a photoinitiator and specific light for photo-immobilization, the thiol-yne click reaction offers spatial and temporal control, with the absence of transition metal catalysts mitigating concerns of cytotoxicity and metal contamination, rendering it suitable for biomedical applications. The objectives of this research encompass demonstrating the feasibility of the thiol-yne click reaction for surface functionalization and enriching bioconjugation strategies for tailoring PLLA surfaces, ultimately advancing biomedical technologies through precise control over surface properties and functionality. For this purpose, PLLA surfaces were activated through hydrolysis and amidation to introduce the activated alkyne moiety (PLLA-Alkyne), followed by photo-induced dansyl immobilization (PLLA-Dns) with Irgacure 651. Various surface characterization techniques, including SEM, WCA, XPS, ATR-FTIR, and fluorescence microscopy and spectroscopy, validated the successful conjugation. This metal-free method preserves the material’s bulk properties while enabling thiol-containing molecule immobilization. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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17 pages, 3539 KiB  
Article
Chitosan-Caffeic Acid Antibacterial Coating for PDMS Surfaces: A Sustained Moxifloxacin Release and Prolonged Coating Adhesion
by Felipe da Silva Veloso, Pascale Chevallier, Helton José Wiggers, Francesco Copes, Bernard Drouin and Diego Mantovani
Coatings 2024, 14(3), 291; https://doi.org/10.3390/coatings14030291 - 28 Feb 2024
Viewed by 1591
Abstract
Central venous catheters (CVCs) are largely used to administer chemotherapy, hemodialysis, and other treatments. Mostly made of polydimethylsiloxane (PDMS), these medical devices present an intrinsic risk of infection due to the possible formation of biofilm, thus increasing the risk of complications. Drug-releasing polymer [...] Read more.
Central venous catheters (CVCs) are largely used to administer chemotherapy, hemodialysis, and other treatments. Mostly made of polydimethylsiloxane (PDMS), these medical devices present an intrinsic risk of infection due to the possible formation of biofilm, thus increasing the risk of complications. Drug-releasing polymer coatings are a well-recognized strategy for combating biofilm formation. However, adhesion of the coating to the substrate over time is a major challenge. Therefore, this work aimed to design a chitosan-based coating designed to have maximum adhesion and stability to guarantee sustained drug release and antibacterial properties for at least 14 days. A coating composed of chitosan (CS) as a drug carrier, caffeic acid (CA) and copper sulphate (Cu) as crosslinkers, and moxifloxacin (Mox) as an antibiotic, was deposited through a controlled casting process onto functionalized PDMS surface. PDMS surface modification was investigated by X-ray photoelectron spectroscopy (XPS), and Fourier-transfer infrared (FTIR). Antibiotic release over time was measured in pseudo-physiological conditions (pH 7.4 and at 37 °C). Indirect cytotoxicity assays were performed on human dermal fibroblasts (HDF). The adhesion of the as-designed coating was evaluated by a specially designed pull-off test, before and after aging for 14 days in PBS. XPS and FTIR analyses confirmed the successful PDMS surface modification. The CS-CA-Cu-Mox coating resulted in being non-cytotoxic towards HDF and exhibited sustained moxifloxacin release for up to 49 days. Furthermore, the CS-CA and CS-CA-Cu coatings presented antibacterial activity for 21 days against E. coli, and for 14 days against S. aureus. Importantly, the coating maintained stable adhesion after 14 days in pseudo-physiological conditions. This study provides new insights into the adhesion behavior of polymeric coatings for medical devices, which is rarely reported in the literature. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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17 pages, 6065 KiB  
Article
Surface Modification of Pure Mg for Enhanced Biocompatibility and Controlled Biodegradation: A Study on Graphene Oxide (GO)/Strontium Apatite (SrAp) Biocomposite Coatings
by Oktay Yigit, Turan Gurgenc, Burak Dikici, Mosab Kaseem, Carl Boehlert and Ersin Arslan
Coatings 2023, 13(5), 890; https://doi.org/10.3390/coatings13050890 - 9 May 2023
Cited by 4 | Viewed by 1741
Abstract
Magnesium alloys have excellent biodegradability but suffer from high corrosion rates and unfavorable biological responses. Thus, a surface modification strategy to regulate the corrosion rate and enhance biocompatibility is required. In this study, pure Mg substrate surfaces were coated with strontium apatite (SrAp) [...] Read more.
Magnesium alloys have excellent biodegradability but suffer from high corrosion rates and unfavorable biological responses. Thus, a surface modification strategy to regulate the corrosion rate and enhance biocompatibility is required. In this study, pure Mg substrate surfaces were coated with strontium apatite (SrAp) and graphene oxide (GO) biocomposite structures using the hydrothermal method to increase the biocompatibility of the surface of the Mg and obtain a moderate biodegradation rate. The effect of the GO concentration (0, 2, 4, and 6 wt.%) on the surface microstructure and its corrosion behavior were systematically studied. The corrosion behavior of the coatings was characterized in-vitro using the electrochemical polarization method in Hank’s solution. An EDS-connected SEM was used to examine the coatings’ surface properties. The functional groups of the coatings were identified using ATR-IR spectroscopy. To determine the degree of crystallization and examine the elemental distribution of the coatings, an XRD was used with a grazing incidence attachment. The XRD and SEM-EDS results showed that increasing the GO ratio in the SrAp-based coatings significantly enhanced the homogeneity and crystallinity, and the ATR-IR spectroscopy revealed that the SrAp/GO coatings were rich in functional groups, including hydroxyl, phosphate, and carbonate groups, that are known to promote bone formation and regeneration. The results of the electrochemical polarization tests demonstrated a considerable decrease in the corrosion rates for the samples with SrAp matrix and GO coatings. Additionally, the coatings containing GO exhibited higher polarization resistance (Rp) values, indicating their potential as a promising surface modification technique for biodegradable implants. These findings suggest that incorporating GO into the SrAp coatings could enhance their biocompatibility and provide a moderate biodegradation rate, which is desirable for biomedical applications. Full article
(This article belongs to the Special Issue Advances in Functional Bio-Coatings)
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