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Review

Enzyme-Based Single Solid-State Nanochannel Biosensors

by
L. Miguel Hernández Parra
,
Omar Azzaroni
and
Waldemar A. Marmisollé
*
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), CONICET, Boulevard 113 y 64, La Plata 1900, Argentina
*
Author to whom correspondence should be addressed.
Chemosensors 2025, 13(8), 275; https://doi.org/10.3390/chemosensors13080275
Submission received: 27 June 2025 / Revised: 21 July 2025 / Accepted: 23 July 2025 / Published: 25 July 2025

Abstract

Sensing technologies play a critical role in healthcare, not only for diagnosis and treatment but especially for prevention and early intervention. Recent advances in biology, medicine, and materials science have expanded the landscape of measurable biological markers and enabled the development of nanotechnology-based biosensing platforms. Among the most prominent strategies in biosensing are those that take inspiration from nature, particularly through the integration of biological components such as enzymes. This review focuses on the intersection between enzymatic catalysis and single solid-state nanochannel (SSN) technologies as a promising approach for the development of advanced biosensing devices. We provide an overview of the historical background, current state of the art, and major achievements in enzyme-based biosensors and artificial nanochannel platforms, highlighting their synergistic potential. Particular attention is given to the challenges associated with enzyme integration into artificial environments, including stability and functionality retention, and the strategies employed to overcome them. Finally, we discuss the prospects and limitations of combining enzymes with SSNs, aiming to inspire future research in this emerging and multidisciplinary field.
Keywords: solid-state nanochannels; enzymatic biosensor; iontronics solid-state nanochannels; enzymatic biosensor; iontronics

Share and Cite

MDPI and ACS Style

Hernández Parra, L.M.; Azzaroni, O.; Marmisollé, W.A. Enzyme-Based Single Solid-State Nanochannel Biosensors. Chemosensors 2025, 13, 275. https://doi.org/10.3390/chemosensors13080275

AMA Style

Hernández Parra LM, Azzaroni O, Marmisollé WA. Enzyme-Based Single Solid-State Nanochannel Biosensors. Chemosensors. 2025; 13(8):275. https://doi.org/10.3390/chemosensors13080275

Chicago/Turabian Style

Hernández Parra, L. Miguel, Omar Azzaroni, and Waldemar A. Marmisollé. 2025. "Enzyme-Based Single Solid-State Nanochannel Biosensors" Chemosensors 13, no. 8: 275. https://doi.org/10.3390/chemosensors13080275

APA Style

Hernández Parra, L. M., Azzaroni, O., & Marmisollé, W. A. (2025). Enzyme-Based Single Solid-State Nanochannel Biosensors. Chemosensors, 13(8), 275. https://doi.org/10.3390/chemosensors13080275

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