Special Issue "Skeletal Muscle Atrophy: Mechanisms at a Cellular Level"
Deadline for manuscript submissions: 15 October 2020.
Interests: neurodegenerative diseases; androgens; polyglutamine; metabolism; skeletal muscle
Interests: neurotoxins; muscle paralysis; neuromuscular junction; neuromuscular disorders; nerve regeneration
Skeletal muscles constitute the largest body organ, making up about half of a mammal’s bodyweight. Several conditions, including neuromuscular disorders, aging, cancer, and those associated with toxins, can lead to losses in muscle mass and function. This acquired condition, referred to as muscle atrophy, is an emerging health concern and a burden for human health. The cellular and molecular factors involved in muscle atrophy are still relatively unknown, despite great effort being made over the last two decades to decipher the pathophysiological bases underlying muscle loss. A wide range of cellular (e.g., myocites and satellite cells) and subcellular (e.g., neuromuscular junctions) compartments, organelles (e.g., mitochondria, ER, SR), degradation pathways (e.g., UPS and autophagy), molecular signaling networks (e.g., AKT, mTOR, etc.), and genes (e.g., atrogenes) have been identified as critical players in the regulation of muscle mass and atrophy and may play roles in the plasticity and vulnerability of muscle tissue under physiological and pathological conditions.
This Special Issue of Cells aims to provide a general overview of the cellular and molecular mechanisms responsible for muscle atrophy and to stimulate the identification of novel strategies to tackle conditions or disorders associated with muscle loss.
We look forward to your contributions.
Dr. Maria Pennuto
Dr. Marco Pirazzini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- muscle atrophy
- muscle proteostasis
- muscle disuse
- neuromuscular disorder
- muscle degeneration
- neuromuscular paralysis
- cancer cachexia
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Protein arginine methyltransferases in skeletal muscle and neuromuscular function
Authors: Jong-sun Kang
Affiliation: SungKyunKwan University, Suwon, South Korea
Title: Future use of myostatin – learning from the past
Authors: John Vissing
Affiliation: Department of Neurology, University of Copenhagen, Copenhagen, Denmark
Title: Insights into muscle atrophy from mass spectrometry profiling: Common properties of myocellular proteomes under stress
Authors: Siegfried Labeit
Affiliation: Medical Faculty Mannheim, University of Heidelberg, Germany