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NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy

Institut de Neurociències (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain
Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain
Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Current address: Institut Necker Enfants-Malades (INEM), INSERM U1151, Laboratory “Hormonal regulation of brain development and functions”—Team 8, Université Paris Descartes, Sorbonne Paris Cité, 75015 Paris, France.
Cells 2020, 9(7), 1575;
Received: 15 May 2020 / Revised: 23 June 2020 / Accepted: 24 June 2020 / Published: 28 June 2020
(This article belongs to the Special Issue Skeletal Muscle Atrophy: Mechanisms at a Cellular Level)
Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-α (TNFα). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies. View Full-Text
Keywords: NeuroHeal; skeletal muscle atrophy; sirtuin 1; autophagy; proteasome NeuroHeal; skeletal muscle atrophy; sirtuin 1; autophagy; proteasome
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MDPI and ACS Style

Marmolejo-Martínez-Artesero, S.; Romeo-Guitart, D.; Mañas-García, L.; Barreiro, E.; Casas, C. NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. Cells 2020, 9, 1575.

AMA Style

Marmolejo-Martínez-Artesero S, Romeo-Guitart D, Mañas-García L, Barreiro E, Casas C. NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy. Cells. 2020; 9(7):1575.

Chicago/Turabian Style

Marmolejo-Martínez-Artesero, Sara, David Romeo-Guitart, Laura Mañas-García, Esther Barreiro, and Caty Casas. 2020. "NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy" Cells 9, no. 7: 1575.

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