The Roles of Notch Signaling in Cancers

Dear Colleagues,

The Notch signaling pathway is a conserved system involved in embryonic cell fate decisions and in the maintenance of adult stem cells through cell to cell communication. Many studies have shown the relevance of Notch signaling in different human diseases and in particular in cancer, where it is emerging as a major player. Indeed, dysregulation of Notch signaling has been found in a variety of human malignancies, where it is involved in either survival or death pathways, growth arrest, or proliferation and differentiation. The cellular outcome of this aberrant Notch signaling is highly dependent on the context and on the interactions with the tumor microenvironment; thus, it is not surprising that Notch receptors can act as an oncogene or tumor suppressor in different contexts. This Special Issue is aimed at summarizing the current knowledge on the role of Notch in cancer and possible therapeutic perspectives.

Dr. Catia Giovannini
Guest Editor

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