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Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression

Institute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland
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Cells 2020, 9(8), 1879; https://doi.org/10.3390/cells9081879
Received: 20 July 2020 / Revised: 4 August 2020 / Accepted: 5 August 2020 / Published: 11 August 2020
(This article belongs to the Special Issue The Roles of Notch Signaling in Cancers)
The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in preserving self-renewal and amplification of cancer stem cells, supporting the formation, spread and recurrence of the tumor. As the function of Notch signaling is context dependent, we here provide an overview of its activity in a variety of tumors, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells. Finally, we analyze the potential of molecules of the Notch pathway as diagnostic and therapeutic tools against the various cancers. View Full-Text
Keywords: Notch signaling pathway; cancer; stem cells; cancer stem cells; radioresistance; chemoresistance; cancer therapy; metastasis; cancer diagnosis Notch signaling pathway; cancer; stem cells; cancer stem cells; radioresistance; chemoresistance; cancer therapy; metastasis; cancer diagnosis
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MDPI and ACS Style

Meisel, C.T.; Porcheri, C.; Mitsiadis, T.A. Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression. Cells 2020, 9, 1879. https://doi.org/10.3390/cells9081879

AMA Style

Meisel CT, Porcheri C, Mitsiadis TA. Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression. Cells. 2020; 9(8):1879. https://doi.org/10.3390/cells9081879

Chicago/Turabian Style

Meisel, Christian T., Cristina Porcheri, and Thimios A. Mitsiadis 2020. "Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression" Cells 9, no. 8: 1879. https://doi.org/10.3390/cells9081879

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