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Special Issue "Autophagy in Neurodegenerative Diseases"
Deadline for manuscript submissions: closed (30 September 2019).
Cellular homeostasis depends on the proper functioning of quality control systems, among which autophagy plays a pivotal role. The clearance of misfolded proteins and aggregates and the turnover of organelles are essential to guarantee normal cellular function, particularly in post-mitotic cells like neurons, which require effective and constitutive autophagic activity to maintain cellular viability.
Growing evidence indicates a role of autophagy dysfunction in many human diseases, especially in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease Huntington’s disease and amyotrophic lateral sclerosis, among others. In recent years, a vast amount of work has facilitated a better understanding of the role of autophagy in neurons and the origin and consequences of autophagic failure in each neurodegenerative disease.
The elucidation of dysfunctional autophagic processes may help in the design of new therapeutic approaches based on autophagy modulation to ultimately attenuate or prevent neurodegeneration.
This Special Issue aims to summarize the current knowledge on the role of autophagy in neurodegeneration and the ongoing therapeutic modulation of autophagy as a new challenge to fight neurodegenerative diseases.
Dr. Marta Martinez-Vicente
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- lysosomal dysfunction
- neurodegenerative diseases
- Parkinson’s disease,
- Huntington’s disease
- Alzheimer’s disease
- endosomal–lysosomal system
- therapeutic autophagy modulators