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Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

by Marie-Laure Arotcarena 1,2,†, Margaux Teil 1,2,† and Benjamin Dehay 1,2,*
1
Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France
2
CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(6), 565; https://doi.org/10.3390/cells8060565
Received: 28 May 2019 / Revised: 6 June 2019 / Accepted: 8 June 2019 / Published: 9 June 2019
(This article belongs to the Special Issue Autophagy in Neurodegenerative Diseases)
Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the synucleinopathies present as Lewy bodies in Parkinson’s disease, dementia with Lewy bodies, or glial cytoplasmic inclusions in multiple system atrophy. These neurodegenerative diseases also exhibit cellular dyshomeostasis, such as autophagy impairment. Several decades of research have questioned the potential link between the autophagy machinery and alpha-synuclein protein toxicity in synucleinopathy and neurodegenerative processes. Here, we aimed to discuss the active participation of autophagy impairment in alpha-synuclein accumulation and propagation, as well as alpha-synuclein-independent neurodegenerative processes in the field of synucleinopathy. Therapeutic approaches targeting the restoration of autophagy have started to emerge as relevant strategies to reverse pathological features in synucleinopathies. View Full-Text
Keywords: Parkinson’s disease; multiple system atrophy; synucleinopathy; α-synuclein; macroautophagy; chaperone-mediated autophagy; mitophagy; neurodegeneration Parkinson’s disease; multiple system atrophy; synucleinopathy; α-synuclein; macroautophagy; chaperone-mediated autophagy; mitophagy; neurodegeneration
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Arotcarena, M.-L.; Teil, M.; Dehay, B. Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery. Cells 2019, 8, 565.

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