Advances in iPSC-Based Disease Modeling: From Two Dimensional Monolayers to Organoids

Dear Colleagues, 

Understanding the mechanisms underlying human diseases is important for the development of effective therapeutic strategies. Progress made during the last decade in stem cell biology with the discovery of induced pluripotent stem cell (iPSC) technology offers unprecedented opportunities to model human diseases. Disease-relevant cell types differentiated from iPSCs in two-dimensional (2D) monolayers have proven to be an extraordinary tool for uncovering diseases’ underlying molecular mechanisms. Interestingly, recent advances in this direction have led to the development of iPSC-derived 3D organoids that can more accurately recapitulate organ architecture, serving as a biological platform for investigating organs and tissues’ developmental processes under both normal and pathological conditions and paving the way for disease modeling, therapeutics, and regenerative medicine.

In this Special Issue of Cells, we invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of Disease Modeling with Human Induced Pluripotent Stem Cells. Articles describing mechanistic, functional, and cellular aspects of disease models based on iPSCs and iPSC-derived organoids are highly welcome.

Prof. Dr. Giovanni Cuda
Dr. Elvira Immacolata Parrotta
Guest Editors

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