Toll-Like Receptors in Pathologies

Dear Colleagues,

Toll-like receptors (TLRs) belong to pattern recognition receptors expressed by the most cells as transmembrane receptors or within endosomal compartments.

They play a key role in the innate immune system, and their involvement in the several immune and non-immune diseases is currently a matter of great debate and controversy.

Excessive TLR activation can be associated with systemic inflammation, tissue damage, and organ dysfunction.

Cumulative evidence suggests the contribution of TLR signaling dysregulation to the development and progression of almost all diseases, such as neurodegenerative diseases, cancer, chronic inflammation, autoimmune diseases, infectious disease, cardiovascular disorders, inflammatory bowel disease, asthma, obesity, type 2 diabetes mellitus, etc.

This Topical Collection will feature papers on in vitro and animal models of diseases, as well as on patients. The focus is on better understanding the molecular and cellular role of TLRs in the pathogenesis of diseases as well as their potential use as druggable targets for future therapeutics.

Dr. Carmela Conte
Collection Editor

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