Special Issue "Sphingolipids: From Pathology to Therapeutic Perspectives"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 May 2020.
Interests: sphingolipids; sphingosine-1-phosphate (S1P) S1P-lyase; neurodegeneration; autophagy; neurons; microglia; neuroglia
Sphingolipids are ubiquitous components of cellular membranes. Following their discovery in the brain and first description in 1884 by J.L.W. Thudichum, sphingolipids were largely overlooked for almost a century, perhaps due to their complexity and enigmatic nature. It was with the discovery of sphingolipidoses, a series of autosomatically inherited diseases caused by mutations of enzymes involved in sphingolipid degradation, leading to their intralysosomal storage, that sphingolipids came back into the limelight. The essential breakthrough came, however, decades later in the 1990s with the discovery that sphingolipids are not just structural elements of cells but also intra- and extracellular signaling molecules. It turned out that not only their complex carbohydrate headgroups but especially their lipid backbones, including ceramide and sphingosine-1-phosphate (S1P), have selective physiological functions. Due to this new concept, sphingolipids emerged as essential players in many pathologies, including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The aim of the present Special Issue is to highlight the function of sphingolipids starting from simple metabolic intermediates up to complex glycosphingolipids in diverse pathologies, with emphasis on the potential relevance of their metabolism for therapeutic strategies.
Prof. Dr. Gerhild van Echten-Deckert
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- sphingosine-1-phosphate (S1P)
- immune modulation