From Research on Vitamin B3, NAD+ and ADP-Ribose Metabolism to Clinical Applications in Human Health
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 24128
Special Issue Editors
Interests: inflammatory signaling; NAD; ADP-ribose; ADP-ribosylation; ADP-ribosyltransferase
Special Issue Information
Dear Colleagues,
Science writer David Rains Wallace once said that “fermentation may have been a better invention than fire.” Tongue-and-cheek, yes, but he was quite right: NAD+, a molecule essential for life, was in fact discovered (in 1906) while studying the mechanism of fermentation. Thirty years of research and three Nobel prizes later, the structure of NAD+ (i.e., a dinucleotide containing nicotinamide and adenine) and its function in fermentation (i.e., redox reactions known as hydride transfers) were resolved. The importance of NAD+ in human health was first demonstrated in 1937 when it was reported that the NAD+ biosynthetic precursors nicotinic acid and nicotinamide (also known as vitamin B3) could effectively be used for the treatment of pellagra, a devastating human disease that is due to NAD+ deficiency.
In the 1960s, a paradigm shift in the NAD+ field occurred when it was shown that an enzyme (now known as PARP1) cleaves the glycosidic bond of NAD+, transfers the ADP-ribose group to amino acid side chains, and forms polymers of ADP-ribose. Fast forward to today, we now know that multiple classes of NAD+-consuming enzymes exist, including PARPs (17 in humans) and other ADP-ribosyltransferases, cyclic ADP-ribose synthases, and NAD+-dependent protein deacetylases which are involved in fundamental processes affecting health and disease. While much focus of current research is on protein acceptors, DNA, RNA, and NAD itself have been identified as acceptors.
This Special Issue honors Myron (Mike) and Elaine Jacobson, who made an indelible imprint on the NAD+ field: from our understanding of NAD+ homeostasis and ADP-ribosylation to developing novel NAD+ precursors for the treatment of human diseases. The aim of this Special Issue is to summarize our current knowledge on the synthesis, biological, and functional roles of NAD+ and its metabolites and how they are clinically applied for human health.
We look forward to your contributions.
Prof. Dr. Michael Hottiger
Dr. Michael S. Cohen
Guest Editors
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Keywords
- vitamin B3
- nicotinic acid
- nicotinamide
- nicotine riboside
- NAD
- ADP-ribose
- ADP-ribosylation
- MARylation
- PARylation
- NAD metabolism
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