Role of the G Protein-Coupled Receptors in Cancer and Stromal Cells: From Functions to Novel Therapeutic Perspectives
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 40879
Special Issue Editor
Interests: estrogen; estrogen receptor; GPER; signal transduction; breast cancer; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Heterotrimeric G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) involved in a multifaceted signalling network through the G-protein coupled receptors (GPCRs) that belong to the largest gene family of cell-surface receptors. Considering that many GPCRs play a key role in numerous physiological functions, their involvement in various human diseases, including cancer, is not surprising. In this regard, emerging evidence strongly suggests that GPCRs may drive certain aberrant features that characterize the tumorigenic processes, such as cell proliferation, survival, invasion, metastasis, angiogenesis, immune evasion, and therapy resistance. To date, GPCRs represent the therapeutic targets of more than a quarter of the clinical drugs currently on the market. A deeper assessment of their action in cancer development may provide a further fascinating chance toward the identification of novel targets to be exploited in drug discovery and tumor treatment in line with the new era of precision medicine.
We invite scientists working on this topic to contribute to this Special Issue. Original research articles or reviews on all aspects related to the molecular and cellular mechanisms through which GPCRs trigger not only cancer cells but also the malignant liaison within the tumor microenvironment are welcome. Articles with insights from biological to therapeutic perspectives are especially welcome.
Prof. Marcello Maggiolini
Guest Editor
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Keywords
- G proteins
- GPCRs
- cancer
- tumor microenvironment
- therapeutic perspectives