Epigenetic Mechanisms of Longevity and Aging

Dear Colleagues,

Epigenetics, defined as heritable changes in gene function or phenotype, in the absence of DNA sequence changes, plays central roles in controlling gene expression in various fields. This is an especially important topic in aging, where epigenetic changes have been recognized as one of the molecular hallmarks of aging. Aging is associated with numerous molecular changes, such as altered metabolism, differential gene expression, and accumulated DNA damage. These changes are considered a general cause of aging, frailty and decreased life span.  While some mechanisms of the interplay between aging and epigenetics have been extensively studied in the last decade, the full understating of such processes is far from completion. In this Special Issue, we will consider state-of-the-art, innovative, and up-to-date studies that are in accordance with the exploration of roles of epigenetics in aging, using humans or other model organisms or substrates that will shed some light on this complex interaction. We invite you to contribute your thoughts, research articles and reviews of existing literature to this exciting new Special Issue.

Prof. Dr. Gil Atzmon
Dr. Michael Klutstein
Dr. Yitzhak Reizel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.