The 15th Anniversary of Genes: Feature Papers in the Human Genomics and Genetic Diseases Section

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 678

Special Issue Editors


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Guest Editor
Epigenetics and Genomics of Aging/Longevity, Department of Biology, Faculty of Natural Sciences University of Haifa Mount Carmel, Haifa 31905, Israel
Interests: longevity; genomic; epigenomic; genetic; epigenetic; healthy aging; healthy lifespan; diabetes
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Medical and Surgical Advanced Sciences, Second Division of Neurology , Center for Rare Neurological and Neuromuscular Diseases & Inter University Center for Research in Neurosciences, University of Campania Luigi Vanvitelli, Naples , Italy
2. Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Interests: genetics of rare neurologic and neuromuscular diseases; translational neurogenetics; clinical & molecular neurogenetics; applied stem cell biology; systems neuroscience; neuropathology and experimental neurobiology; nanotechnology in nutraceuticals and functional fods; roles of autophagy in neurodegenerative diseases; clinical neurology of adults and children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “The 15th Anniversary of Genes: Feature Papers in the Human Genomics and Genetic Diseases Section”, will gather high-quality reviews or research articles on all aspects of human health and disease, as well as the diagnosis, treatment, and prognosis of genetic disorders and heritable or acquired cancers. It will be dedicated to recent advances in the research area of genomics and genetics and will comprise a selection of exclusive papers from the Editorial Board Members (EBMs) of the Human Genomics and Genetic Section, as well as invited papers from relevant experts. We also invite senior experts in the field to contribute to this Special Issue.

This Special Issue will celebrate the 15th anniversary of Genes and the 10th anniversary of the journal receiving its first impact factor. We aim to showcase our section as an attractive open access publishing platform for genomics and genetic research.

Prof. Dr. Gil Atzmon
Prof. Dr. Mariarosa Anna Beatrice Melone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genetics of monogenic diseases and complex diseases
  • genotype–phenotype relationships
  • population genomics and genetic epidemiology
  • precision medicine
  • pharmacogenetics and pharmacogenomics
  • targeted genome editing
  • gene therapy and delivery systems
  • genetically engineered cell therapy
  • RNA- and small nucleic acid-based therapeutics
  • genetic testing and molecular diagnostics
  • biomarker development and application
  • genome-wide association studies
  • epigenetic therapy
  • developmental genetics, epigenetics, and epigenomics

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Published Papers (1 paper)

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Review

19 pages, 1286 KiB  
Review
Advances in Genitourinary Tumor Genomics and Immunotherapy
by Jasmine Vohra, Gabriela Barbosa, Lívia Bitencourt Pascoal and Leonardo O. Reis
Genes 2025, 16(6), 667; https://doi.org/10.3390/genes16060667 - 30 May 2025
Viewed by 528
Abstract
Advancements in immune monitoring and modulation technologies are driving transformative changes in cancer immunotherapy. These innovations are crucial for assessing patient-specific immune responses, enabling more accurate predictions of therapeutic efficacy and enhancing treatment outcomes. This review provides a comprehensive overview of current technologies [...] Read more.
Advancements in immune monitoring and modulation technologies are driving transformative changes in cancer immunotherapy. These innovations are crucial for assessing patient-specific immune responses, enabling more accurate predictions of therapeutic efficacy and enhancing treatment outcomes. This review provides a comprehensive overview of current technologies used in immune monitoring, such as flow cytometry, single-cell RNA sequencing, and multiplex cytokine profiling. It also explores cutting-edge immune modulation methods, such as biomaterials that activate immune cells and genetically engineered cell-based therapies. We examine the strengths and limitations of these techniques and identify areas where further progress is needed. In particular, we explore how personalized therapies, real-time monitoring systems, and artificial intelligence shape the future of immune-based treatments. Through a comparative analysis of existing platforms and emerging solutions, this paper underscores the importance of integrating diverse scientific approaches—from immunology and bioengineering to data science—in advancing safer, more effective cancer treatments. This interdisciplinary approach promises to enhance the precision and accessibility of immune-based therapies, offering new hope for improved cancer care. Full article
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