Special Issue "Double-Strand DNA Break Repair and Human Disease"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".

Deadline for manuscript submissions: 15 June 2020.

Special Issue Editor

Prof. Dr. George Iliakis
E-Mail Website
Guest Editor
Institute of Medical Radiation Biology, University of Duisburg-Essen, Medical School, Hufeland Str. 55, 45122 Essen, Germany
Interests: DNA double-strand breaks and their processing in the development of cancer and cellular responses to ionizing radiation
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

DNA double-strand breaks (DSBs) are highly consequential invertebrates because they pose unique requirements for their repair. In line with this unique characteristic, as lesions, DSBs are processed by four mechanistically distinct repair pathways: Classical non-homologous end-joining (c-NHEJ), gene conversion (GC)—a homologous recombination repair (HRR) subpathway, single-strand annealing (SSA), and alternative end-joining (alt-EJ). It is surprising that among these DSB repair pathways only GC is mechanistically equipped to restore the genome. The function of all other DSB repair pathways is associated with alterations at the DSB junction, as well as with the formation of translocations—both events that feed genomic instability and carcinogenesis. The evolution of DSB processing options with such a spectrum of mechanisms and outcomes suggests an underlying logic and flexible adaptation to necessities that are presently being elucidated. The present issue of Cells combines articles that summarize the state-of-the-art in DSB processing pathways, pathway utilization, and their consequences for genomic instability, carcinogenesis, and cancer treatment. Articles with breakthrough ideas and hypotheses that move the field forward are encouraged.

Prof. Dr. George Iliakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • DNA double-strand breaks
  • Gene conversion
  • C-NHEJ
  • Single-strand annealing
  • Alternative end-joining
  • Ionizing radiation
  • Genomic instability
  • Cancer development
  • Cancer treatment

Published Papers

This special issue is now open for submission.
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