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Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution

Department. of Biology, Tufts University, Medford, MA 02155, USA
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Author to whom correspondence should be addressed.
Cells 2020, 9(7), 1657; https://doi.org/10.3390/cells9071657
Received: 23 June 2020 / Revised: 6 July 2020 / Accepted: 7 July 2020 / Published: 9 July 2020
(This article belongs to the Special Issue Double-Strand DNA Break Repair and Human Disease)
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer. View Full-Text
Keywords: alt-EJ; polymerase theta; microhomology-mediated end joining; chromosome rearrangements; resection alt-EJ; polymerase theta; microhomology-mediated end joining; chromosome rearrangements; resection
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MDPI and ACS Style

Hanscom, T.; McVey, M. Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution. Cells 2020, 9, 1657. https://doi.org/10.3390/cells9071657

AMA Style

Hanscom T, McVey M. Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution. Cells. 2020; 9(7):1657. https://doi.org/10.3390/cells9071657

Chicago/Turabian Style

Hanscom, Terrence, and Mitch McVey. 2020. "Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution" Cells 9, no. 7: 1657. https://doi.org/10.3390/cells9071657

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