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Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks

Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA
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Cells 2020, 9(7), 1699; https://doi.org/10.3390/cells9071699
Received: 4 June 2020 / Revised: 10 July 2020 / Accepted: 14 July 2020 / Published: 16 July 2020
(This article belongs to the Special Issue Double-Strand DNA Break Repair and Human Disease)
Eukaryotic cells are constantly exposed to both endogenous and exogenous stressors that promote the induction of DNA damage. Of this damage, double strand breaks (DSBs) are the most lethal and must be efficiently repaired in order to maintain genomic integrity. Repair of DSBs occurs primarily through one of two major pathways: non-homologous end joining (NHEJ) or homologous recombination (HR). The choice between these pathways is in part regulated by histone post-translational modifications (PTMs) including ubiquitination. Ubiquitinated histones not only influence transcription and chromatin architecture at sites neighboring DSBs but serve as critical recruitment platforms for repair machinery as well. The reversal of these modifications by deubiquitinating enzymes (DUBs) is increasingly being recognized in a number of cellular processes including DSB repair. In this context, DUBs ensure proper levels of ubiquitin, regulate recruitment of downstream effectors, dictate repair pathway choice, and facilitate appropriate termination of the repair response. This review outlines the current understanding of histone ubiquitination in response to DSBs, followed by a comprehensive overview of the DUBs that catalyze the removal of these marks. View Full-Text
Keywords: DNA damage response; double strand break repair; DSBs; histones; ubiquitination; deubiquitinases; deubiquitinating enzymes; DUBs DNA damage response; double strand break repair; DSBs; histones; ubiquitination; deubiquitinases; deubiquitinating enzymes; DUBs
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MDPI and ACS Style

Aquila, L.; Atanassov, B.S. Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks. Cells 2020, 9, 1699. https://doi.org/10.3390/cells9071699

AMA Style

Aquila L, Atanassov BS. Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks. Cells. 2020; 9(7):1699. https://doi.org/10.3390/cells9071699

Chicago/Turabian Style

Aquila, Lanni; Atanassov, Boyko S. 2020. "Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks" Cells 9, no. 7: 1699. https://doi.org/10.3390/cells9071699

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