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Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication

1
Chemistry Department and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia
2
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow 119234, Russia;
*
Author to whom correspondence should be addressed.
Cells 2020, 9(8), 1907; https://doi.org/10.3390/cells9081907
Received: 5 July 2020 / Revised: 13 August 2020 / Accepted: 14 August 2020 / Published: 16 August 2020
(This article belongs to the Special Issue Double-Strand DNA Break Repair and Human Disease)
The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer. The kinase activity of DNA-PK is required for efficient repair of DNA double-strand breaks (DSB) by non-homologous end joining (NHEJ). We also showed that the kinase activity of DNA-PK is essential for post-integrational DNA repair in the case of HIV-1 infection. Besides, DNA-PK is known to participate in such cellular processes as protection of mammalian telomeres, transcription, and some others where the need for its phosphorylating activity is not clearly elucidated. We carried out a systematic search and analysis of DNA-PK targets described in the literature and identified 67 unique DNA-PK targets phosphorylated in response to various in vitro and/or in vivo stimuli. A functional enrichment analysis of DNA-PK targets and determination of protein–protein associations among them were performed. For 27 proteins from these 67 DNA-PK targets, their participation in the HIV-1 life cycle was demonstrated. This information may be useful for studying the functioning of DNA-PK in various cellular processes, as well as in various stages of HIV-1 replication. View Full-Text
Keywords: DNA-PK; HIV-1; DNA-damage; HIV-1 transcription regulation; post-integrational repair DNA-PK; HIV-1; DNA-damage; HIV-1 transcription regulation; post-integrational repair
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MDPI and ACS Style

Anisenko, A.; Kan, M.; Shadrina, O.; Brattseva, A.; Gottikh, M. Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication. Cells 2020, 9, 1907. https://doi.org/10.3390/cells9081907

AMA Style

Anisenko A, Kan M, Shadrina O, Brattseva A, Gottikh M. Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication. Cells. 2020; 9(8):1907. https://doi.org/10.3390/cells9081907

Chicago/Turabian Style

Anisenko, Andrey; Kan, Marina; Shadrina, Olga; Brattseva, Anna; Gottikh, Marina. 2020. "Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication" Cells 9, no. 8: 1907. https://doi.org/10.3390/cells9081907

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