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Cells
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Biomarkers and Cellular Biology in Perioperative Medicine
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Biomarkers and Cellular Biology in Perioperative Medicine

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 8480

Special Issue Editors

Dr. Markus M. Luedi

E-Mail Website
Guest Editor
Cantonal Hospital of St. Gallen, CH-9007 St. Gallen, Switzerland
Interests: biobanking; cardiovascular medicine; molecular biology; translational research; biomarkers
Special Issues, Collections and Topics in MDPI journals
Dr. Jan Larmann

E-Mail Website
Guest Editor
Department of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany
Interests: perioperative cardiac biomarkers; perioperative immune-modulation, digital medicine; perioperative data science

Special Issue Information

Dear Colleagues,

Surgical procedures alter tissue integrity, and contact with foreign materials implanted perioperatively induces a number of inflammatory reactions. Depending on the magnitude of such perioperative trauma, the molecular and cellular impact on homeostasis is tremendous, and postoperative injury-associated immunosuppression (IAI) has been shown to occur in a significant number of patients. The use of cardiopulmonary bypass (CPB), for example, may aggravate perioperative immunosuppression. However, biomarkers and cellular responses in perioperative medicine are generally neither specifically monitored nor well understood.

This Special Issue aims to investigate current developments and mechanistic discoveries regarding the impact of surgical and interventional procedures on organ systems. We provide a wide range of state-of-the-art papers from respected experts in anesthesiology and perioperative medicine.

Dr. Markus M. Luedi
Dr. Jan Larmann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • perioperative medicine
  • metabolics
  • acute phase proteins
  • inflammation
  • trauma
  • anesthesiology
  • cardiopulmonary bypass
  • perioperative immunosuppression

Published Papers (4 papers)

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Editorial

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2 pages, 178 KiB  
Editorial
Biomarkers and Cellular Biology in Perioperative Medicine
by Jan Larmann and Markus M. Luedi
Cells 2022, 11(7), 1147; https://doi.org/10.3390/cells11071147 - 29 Mar 2022
Viewed by 1403
Abstract
Surgical procedures alter tissue integrity; are associated with pain and activation of the sympathetic nervous system; and sometimes, cause exposure to foreign materials used during the surgery or implanted perioperatively [...] Full article
(This article belongs to the Special Issue Biomarkers and Cellular Biology in Perioperative Medicine)

Research

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13 pages, 1556 KiB  
Article
Improved Diagnosis of Iron Deficiency Anemia in the Critically Ill via Fluorescence Flowcytometric Hemoglobin Biomarkers
by Mascha Zuther, Marie-Luise Rübsam, Mathias Zimmermann, Alexander Zarbock and Christian Hönemann
Cells 2023, 12(1), 140; https://doi.org/10.3390/cells12010140 - 29 Dec 2022
Cited by 5 | Viewed by 1992
Abstract
Background: Iron deficiency anemia (IDA) is common in critically ill patients treated in the intensive care unit (ICU), and it can lead to severe consequences. Precise and immediate diagnostics are not available, but they are inevitably needed to administer adequate therapy. Serological parameters [...] Read more.
Background: Iron deficiency anemia (IDA) is common in critically ill patients treated in the intensive care unit (ICU), and it can lead to severe consequences. Precise and immediate diagnostics are not available, but they are inevitably needed to administer adequate therapy. Serological parameters such as serum ferritin and transferrin saturation (TSAT) are heavily influenced by simultaneous inflammation reactions, resulting in the need for more suitable parameters. Reticulocyte biomarkers such as reticulocyte hemoglobin content (RET-He) and Delta-hemoglobin equivalent (Delta-He) determined by fluorescence flowcytometry are more specific for the diagnosis of IDA-based anemia and should be investigated for this purpose. Methods: In a prospective cohort single-center study, serum ferritin and transferrin saturation (TSAT) were collected and compared to RET-He and Delta-He by performing a receiver operating curve (ROC) analysis. The sensitivity and specificity of a single variable or the combination of two variables, as well as cutoff values, for the diagnosis of IDA were calculated. A group comparison for IDA patients without IDA was performed for a control group. Results: A total of 314 patients were enrolled from an interdisciplinary ICU. RET-He (area under the curve (AUC) 0.847) and Delta-He (AUC 0.807) did indicate iron-deficient anemia that was more specific and sensitive in comparison to serum ferritin (AUC 0.678) and TSAT (AUC 0.754). The detection of functional iron deficiency (FID) occurred in 28.3% of cases with anemia. Conclusions: Determination of RET-He and Delta-He allows for the increased precision and sensitivity of iron-deficient anemia in the ICU. Full article
(This article belongs to the Special Issue Biomarkers and Cellular Biology in Perioperative Medicine)
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9 pages, 689 KiB  
Article
Inflammatory Glycoprotein YKL-40 Is Elevated after Coronary Artery Bypass Surgery and Correlates with Leukocyte Chemotaxis and Myocardial Injury, a Pilot Study
by Antti Laurikka, Katriina Vuolteenaho, Vesa Toikkanen, Timo Rinne, Tiina Leppänen, Mari Hämäläinen, Matti Tarkka, Jari Laurikka and Eeva Moilanen
Cells 2022, 11(21), 3378; https://doi.org/10.3390/cells11213378 - 26 Oct 2022
Cited by 1 | Viewed by 1275
Abstract
The aim of the present study was to investigate the levels of YKL-40 during and after coronary artery bypass grafting surgery (CABG) and to establish possible connections between YKL-40 and markers of oxidative stress, inflammation, and myocardial injury. Patients undergoing elective CABG utilizing [...] Read more.
The aim of the present study was to investigate the levels of YKL-40 during and after coronary artery bypass grafting surgery (CABG) and to establish possible connections between YKL-40 and markers of oxidative stress, inflammation, and myocardial injury. Patients undergoing elective CABG utilizing cardiopulmonary bypass (CPB) were recruited into the study. Blood samples were collected at the onset of anesthesia, during surgery and post-operatively. Levels of YKL-40, 8-isoprostane, interleukin-8 (IL-8), monocyte chemotactic protein-1 (MCP-1) and troponin T (TnT) were measured by immunoassay. YKL-40 levels increased significantly 24 h after CPB. Positive correlation was seen between post-operative TnT and YKL-40 levels (r = 0.457, p = 0.016) and, interestingly, baseline YKL-40 predicted post-operative TnT increase (r = 0.374, p = 0.050). There was also a clear association between YKL-40 and the chemotactic factors MCP-1 (r = 0.440, p = 0.028) and IL-8 (r = 0.484, p = 0.011) linking YKL-40 to cardiac inflammation and fibrosis following CABG. The present results show, for the first time, that YKL-40 is associated with myocardial injury and leukocyte-activating factors following coronary artery bypass surgery. YKL-40 may be a factor and/or biomarker of myocardial inflammation and injury and subsequent fibrosis following heart surgery. Full article
(This article belongs to the Special Issue Biomarkers and Cellular Biology in Perioperative Medicine)
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Review

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14 pages, 697 KiB  
Review
Endothelial Progenitor Cells as Biomarkers of Cardiovascular Pathologies: A Narrative Review
by Paul Philipp Heinisch, Corina Bello, Maximilian Y. Emmert, Thierry Carrel, Martina Dreßen, Jürgen Hörer, Bernhard Winkler and Markus M. Luedi
Cells 2022, 11(10), 1678; https://doi.org/10.3390/cells11101678 - 18 May 2022
Cited by 17 | Viewed by 2961
Abstract
Endothelial progenitor cells (EPC) may influence the integrity and stability of the vascular endothelium. The association of an altered total EPC number and function with cardiovascular diseases (CVD) and risk factors (CVF) was discussed; however, their role and applicability as biomarkers for clinical [...] Read more.
Endothelial progenitor cells (EPC) may influence the integrity and stability of the vascular endothelium. The association of an altered total EPC number and function with cardiovascular diseases (CVD) and risk factors (CVF) was discussed; however, their role and applicability as biomarkers for clinical purposes have not yet been defined. Endothelial dysfunction is one of the key mechanisms in CVD. The assessment of endothelial dysfunction in vivo remains a major challenge, especially for a clinical evaluation of the need for therapeutic interventions or for primary prevention of CVD. One of the main challenges is the heterogeneity of this particular cell population. Endothelial cells (EC) can become senescent, and the majority of circulating endothelial cells (CEC) show evidence of apoptosis or necrosis. There are a few viable CECs that have properties similar to those of an endothelial progenitor cell. To use EPC levels as a biomarker for vascular function and cumulative cardiovascular risk, a correct definition of their phenotype, as well as an update on the clinical application and practicability of current isolation methods, are an urgent priority. Full article
(This article belongs to the Special Issue Biomarkers and Cellular Biology in Perioperative Medicine)
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