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Metabolites
Special Issues
Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases
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Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 450

Special Issue Editors

Dr. Mark G. Filipovic

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Guest Editor
Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Interests: cardiovascular; biomarkers; cardiac surgery; anaesthesia; intensive care; risk factors; outcome
Special Issues, Collections and Topics in MDPI journals
Dr. Corina Manuela Bello

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Guest Editor
1. Department of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
2. Institute of Radiology and Nuclear Medicine, Hirslanden Klinik St. Anna, Lucerne, Switzerland
Interests: cardiovascular; biomarkers; anaesthesia; outcomes; patient-centred outcomes; patient satisfaction
Dr. Markus M. Luedi

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Guest Editor
Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
Interests: anesthesiology; management; neuro-oncology; medical statistics; anaesthesiology; resuscitation; anesthesia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a special issue of Metabolites focused on Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases. This special issue aims to highlight the latest advancements in the identification, validation, and clinical application of biomarkers related to cardiovascular health, with an emphasis on the role of metabolomics in understanding disease mechanisms and therapeutic targets.

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide, making the discovery of novel biomarkers and biomarkers-based therapeutic strategies crucial. Metabolomics, as a powerful tool to profile small molecules in complex biological systems, has the potential to provide unique insights into the pathophysiology of cardiovascular conditions and to catalyse personalized medicine approaches.

Dr. Mark G. Filipovic
Dr. Corina Manuela Bello
Dr. Markus M. Luedi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular
  • biomarkers
  • risk factors
  • outcome
  • prognostication
  • metabolism
  • metabolomics
  • risk markers

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Published Papers (1 paper)

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39 pages, 1588 KiB  
Systematic Review
Current Prognostic Biomarkers for Peripheral Arterial Disease: A Comprehensive Systematic Review of the Literature
by Hamzah Khan, Natasha R. Girdharry, Sophia Z. Massin, Mohamed Abu-Raisi, Gustavo Saposnik, Muhammad Mamdani and Mohammad Qadura
Metabolites 2025, 15(4), 224; https://doi.org/10.3390/metabo15040224 - 25 Mar 2025
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Abstract
Background: Peripheral arterial disease (PAD) is a chronic atherosclerotic disease characterized by atheromatous plaque buildup within arteries of the lower limbs. It can lead to claudication, skin ulcerations, and, in severe cases, chronic limb-threatening ischemia, requiring amputation. There are several plasma protein biomarkers [...] Read more.
Background: Peripheral arterial disease (PAD) is a chronic atherosclerotic disease characterized by atheromatous plaque buildup within arteries of the lower limbs. It can lead to claudication, skin ulcerations, and, in severe cases, chronic limb-threatening ischemia, requiring amputation. There are several plasma protein biomarkers that have been suggested as prognostic markers for adverse events, including major adverse cardiovascular and limb events. However, the clinical benefit and ability to clinically adapt these biomarkers remains uncertain due to inconsistent findings possibly related to heterogenous study designs and differences in methodology. Objectives: This review aims to evaluate the current literature on the prognostic value of plasma protein biomarkers for PAD, their predictive ability for PAD-related adverse outcomes, and their potential roles in guiding PAD management. Methods: To address these challenges, we conducted a systematic review of MEDLINE, Embase, and Cochrane CENTRAL libraries of the current literature (2010–2024). Results: We found 55 studies that evaluated the prognostic value of 44 distinct plasma proteins across various pathophysiological processes. These included markers of immunity and inflammation, markers of metabolism, cardiac biomarkers, markers of kidney function, growth factors and hormones, markers of coagulation and platelet function, extracellular matrix and tissue remodeling proteins, and transport proteins. This review summarizes the existing evidence for prognostic protein plasma biomarkers for PAD and their association with adverse events related to PAD. Conclusions: With this review, we hope to provide a comprehensive list of the prognostic markers and their value as prognostic biomarkers to guide clinical decision making in these patients. Full article
(This article belongs to the Special Issue Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases)
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