Autophagy and Human Cancers

Dear Colleagues,

Autophagy is a conserved catabolic process, essential for the maintenance of cellular homeostasis. In cancer, autophagy is related to the cell type, the different tumor, the microenvironment and the stage of the disease. During tumor development, autophagy is able to disfavor malignant transformation, limiting the production of reactive oxygen species and DNA damage. In advanced stages of the disease, autophagy evolves to support cancer progression through the regulation of the immune response or the secretion of cytokines and growth factors. Furthermore, autophagy can be involved in mechanisms of resistance to anticancer therapy. In this Special Issue, we will try to improve the understanding of autophagy mechanisms, especially those involved in the growth and aggressiveness of the tumor and the regulation of resistance to chemotherapy.

Dr. Maria Condello
Prof. Dr. Stefania Meschini
Guest Editors

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