Autophagy and Tumor Microenvironment
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 1820
Special Issue Editor
Interests: characterization of multidrug-resistant tumor cells; in vitro study of apoptosis induced by chemotherapeutic drugs; in vitro study of autophagy (cell survival mechanism or type II programmed cell death); in vitro study of new anticancer strategies based on the use of natural products in combination with drugs, on electrochemotherapy, and on liposomes; study of interaction between cells and metal nanoparticles (ZnO or Ag-NPs) to investigate nanotoxicology
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Special Issue Information
Dear Colleagues,
Autophagy is a conserved catabolic process, essential for the maintenance of cellular homeostasis. It exhibits a dual-sided role in cancer: it promotes clearance of transformed cells and inhibits tumorigenesis, while also sustaining cancer as a drug-resistance mechanism. Autophagy signaling in the tumor microenvironment (TME) during cancer growth and therapy is not adequately understood.
The aims of this Special Issue are the following:
- Highlight the role of autophagy signaling pathways to support cancer growth and progression in adaptation to the oxidative and hypoxic context of the TME;
- Understand the role of autophagy in regulating the metabolic switch for generating sufficient levels of high-energy metabolites for cancer cell survival;
- Clarify its critical role in modulating tumor-associated fibroblasts resulting in cytokine- and paracrine-signaling-mediated angiogenesis and invasion of pre-metastatic niches to secondary tumor sites;
- Understand how autophagy promotes immune evasion to inhibit antitumor immunity;
- Uncover the role of autophagy in the TME in maintaining and supporting the survival of cancer stem cells resulting in chemoresistance and therapy recurrence.
Understanding the molecular mechanisms underlying the multiple roles of autophagy is important for the development of autophagy modulators for autophagy-based cancer therapy.
Dr. Maria Condello
Guest Editor
Manuscript Submission Information
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Keywords
- autophagy
- cancer growth
- cancer therapy
- chemoresistance
- microenvironment
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