Adipose Tissue Inflammation 2022
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 51732
Special Issue Editor
Interests: obesity; dietary treatment; adipose tissue dysfunction; inflammation; adipokines; metabolic surgery; cardiometabolic risk improvement; body composition changes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the last decades, obesity has become one of the most prevalent metabolic disorders. Excess adiposity favors the development of cardiometabolic alterations, such as type 2 diabetes (T2D), cardiovascular disease, dyslipidemia, steatohepatitis, and cancer. In the last years, adipose tissue inflammation has been shown to be one of the major mechanisms underlying adipose tissue dysfunction, contributing to the development of metabolic derangements in other organs. The contribution of the different adipose tissue depots, the discovery of the function of molecules such as MCP-1, the involvement of the inflammasome, or the dual effect of macrophage polarization have greatly contributed to the improved understating produced in the last years, of the role played by adipose tissue inflammation in the development of metabolic alterations.
In this Special Issue, we welcome contributions related to any aspect of adipose tissue inflammation, from mechanistic issues related to the different types of cells involved; the role of proinflammatory molecules; the effect of adipokines; the connection with other processes implicated such as fibrosis, hypoxia, angiogenesis, or extracellular matrix remodeling; to its metabolic consequences. We aim to provide readers with a clear view of the pathophysiological relevance of adipose tissue inflammation and the cross-talk with other organs such as the liver, the skeletal muscle, the pancreas, or the brain, not only in the development of obesity-associated comorbidities, such as T2D or cardiovascular problems, but also in the link with other metabolic alterations, such as non-alcoholic fatty liver disease or dyslipidemia, or in the development of cancer. Studies analyzing the role of adipose tissue inflammation in obesity subphenotyping in relation to the presence of metabolically healthy or unhealthy obesity will be also welcome.
Dr. Javier Gómez-Ambrosi
Guest Editor
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Keywords
- adipose tissue
- inflammation
- obesity
- adipokines
- fibrosis
- ECM remodeling
- macrophage polarization
- type 2 diabetes
- NAFLD
- oxidative stress
- metabolically healthy obesity
- cancer
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