Special Issue "Immune Response in Transplantation"
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 2496
2. Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Interests: hematopoietic stem cell transplant; immune reconstitution; opportunistic infection
Allogeneic hematopoietic stem cell transplant (HCT) is followed by a period of profound immune compromise with defects in both innate and adaptive immunity. Critical to successful HCT is re-establishing both arms of immunity with innate immunity typically being restored in the first month or so after HCT. The reconstitution of T cell immunity occurs more slowly by both homeostatic expansion of populations infused at the time of transplant as well as by de novo thymic dependent T cell production. For over two decades we have understood that the pace of these processes contributes to transplant outcomes including relapse and non-relapse mortality and is controlled by both modifiable and non-modifiable variables. This issue will explore recent advances in measuring as well as modifying the process of immune reconstitution and link these advances to the infectious complications associated with defects in immunity seen after HCT.
We propose a special issue focused on the interaction in the post-hematopoietic stem cell transplant period between components of immune reconstitution and infectious complications. We would solicit manuscripts on reconstitution of innate and adaptive immunity, manuscripts on specific infectious risks related to defects in each of these components of protective immunity, and a position paper on identifying high risk patients and approaches to monitoring in these patients, as well as what the future looks like in this arena.
Dr. Susan E. Prockop
Dr. Tanvi Sharma
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- hematopoietic stem cell transplant
- immune reconstitution
- opportunistic infection