Best Paper Award

The Cells Best Paper Award is granted annually to highlight publications of high quality, scientific significance, and extensive influence. The evaluation committee members choose six articles of exceptional quality that were published in the journal the year before the previous year and announce them online by the end of June.

The Prize:
– First prize (one research article and one review): CHF 500 and a voucher for a full discount on the article processing charge of one paper, valid for one year.
– Second prize (two research articles and two reviews): a voucher for a full discount on the article processing charge of one paper, valid for one year.
– Each winner will receive an electronic certificate.

 
Cells Best Paper Award
 
Winner announcement: 30 June 2026

Eligibility and Requirements

– All papers published in Cells are eligible (both regular and Special Issue submissions).

Selection Criteria

– Scientific merit and broad impact.
– Originality of the research objectives and/or the ideas presented.
– Creativity of the study design or uniqueness of the approaches and concepts.
– Clarity of the presentation.
– Citations and downloads.

 
Past Winners
 
Year: 

Winner

33 pages, 1345 KB  
Review
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
by Chiara Mazziotta, Mauro Tognon, Fernanda Martini, Elena Torreggiani and John Charles Rotondo
Cells 2023, 12(1), 184; https://doi.org/10.3390/cells12010184 - 2 Jan 2023
30 pages, 1693 KB  
Review
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity
by Mateusz Kciuk, Adrianna Gielecińska, Somdutt Mujwar, Damian Kołat, Żaneta Kałuzińska-Kołat, Ismail Celik and Renata Kontek
Cells 2023, 12(4), 659; https://doi.org/10.3390/cells12040659 - 19 Feb 2023
26 pages, 3795 KB  
Review
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
by Juanjuan Wang, Ningning Zhu, Xiaomin Su, Yunhuan Gao and Rongcun Yang
Cells 2023, 12(5), 793; https://doi.org/10.3390/cells12050793 - 2 Mar 2023
21 pages, 4369 KB  
Article
Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin
by Seyeon Oh, Je Hyuk Lee, Hyoung Moon Kim, Sosorburam Batsukh, Mi Jeong Sung, Tae Hwan Lim, Myoung Hoon Lee, Kuk Hui Son and Kyunghee Byun
Cells 2023, 12(9), 1320; https://doi.org/10.3390/cells12091320 - 5 May 2023
13 pages, 3889 KB  
Article
SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation
by Han Su, Aubrey C. Cantrell, Jian-Xiong Chen, Wei Gu and Heng Zeng
Cells 2023, 12(10), 1428; https://doi.org/10.3390/cells12101428 - 19 May 2023
31 pages, 7464 KB  
Article
The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
by Elliot J. Glotfelty, Luis B. Tovar-y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson and Nigel H. Greig
Cells 2023, 12(10), 1367; https://doi.org/10.3390/cells12101367 - 11 May 2023

Award Committee

Dr. Alexander E. Kalyuzhny Chairperson
University of Minnesota
Dr. Francisco Rivero
University of Hull
Dr. Changshun Shao
Prof. Dr. Ursula Stochaj

Winner

36 pages, 3675 KB  
Review
Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs
by Aleksandra Twarda-Clapa, Aleksandra Olczak, Aneta M. Białkowska and Maria Koziołkiewicz
Cells 2022, 11(8), 1312; https://doi.org/10.3390/cells11081312 - 12 Apr 2022
52 pages, 3719 KB  
Review
Microglia Phenotypes in Aging and Neurodegenerative Diseases
by Menbere Y. Wendimu and Shelley B. Hooks
Cells 2022, 11(13), 2091; https://doi.org/10.3390/cells11132091 - 30 Jun 2022
48 pages, 2385 KB  
Review
Interconnections between Inflammageing and Immunosenescence during Ageing
by Thibault Teissier, Eric Boulanger and Lynne S. Cox
Cells 2022, 11(3), 359; https://doi.org/10.3390/cells11030359 - 21 Jan 2022
14 pages, 3009 KB  
Article
S100A8/A9 Is a Marker for the Release of Neutrophil Extracellular Traps and Induces Neutrophil Activation
by Evelien G. G. Sprenkeler, Judith Zandstra, Nadine D. van Kleef, Ines Goetschalckx, Bibian Verstegen, Cathelijn E. M. Aarts, Hans Janssen, Anton T. J. Tool, Gerard van Mierlo, Robin van Bruggen, Ilse Jongerius and Taco W. Kuijpers
Cells 2022, 11(2), 236; https://doi.org/10.3390/cells11020236 - 11 Jan 2022
23 pages, 4210 KB  
Article
Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy
by Daniela Paasch, Johann Meyer, Andriana Stamopoulou, Daniela Lenz, Johannes Kuehle, Doreen Kloos, Theresa Buchegger, Astrid Holzinger, Christine S. Falk, Christina Kloth, Constantin S. von Kaisenberg, Hinrich Abken, Axel Schambach, Nico Lachmann, Michael Morgan and Thomas Moritz
Cells 2022, 11(6), 994; https://doi.org/10.3390/cells11060994 - 15 Mar 2022
19 pages, 4578 KB  
Article
Extracellular Release of Mitochondrial DNA: Triggered by Cigarette Smoke and Detected in COPD
by Luca Giordano, Alyssa D. Gregory, Mireia Pérez Verdaguer, Sarah A. Ware, Hayley Harvey, Evan DeVallance, Tomasz Brzoska, Prithu Sundd, Yingze Zhang, Frank C. Sciurba, Steven D. Shapiro and Brett A. Kaufman
Cells 2022, 11(3), 369; https://doi.org/10.3390/cells11030369 - 22 Jan 2022

Award Committee

Dr. Alexander E. Kalyuzhny Chairperson
University of Minnesota
Dr. Alessandro Poggi
Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino
Dr. Francisco Rivero
University of Hull

Winner

18 pages, 2150 KB  
Article
Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA
by Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni, Vincenzo Camisa, Annapaola Santoro, Rita Brugaletta, Nicola Magnavita, Alessandra Ruggiero, Nicola Cotugno, Donato Amodio, Marta Luisa Ciofi Degli Atti, Daniela Giorgio, Nicoletta Russo, Guglielmo Salvatori, Tiziana Corsetti, Franco Locatelli, Carlo Federico Perno, Salvatore Zaffina and Rita Carsettiadd Show full author list remove Hide full author list
Cells 2021, 10(10), 2541; https://doi.org/10.3390/cells10102541 - 26 Sep 2021
17 pages, 3151 KB  
Article
Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease
by Pradeep K. Shukla, David F. Delotterie, Jianfeng Xiao, Joseph F. Pierre, RadhaKrishna Rao, Michael P. McDonald and Mohammad Moshahid Khan
Cells 2021, 10(4), 779; https://doi.org/10.3390/cells10040779 - 1 Apr 2021
23 pages, 3439 KB  
Article
Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma
by Tomás Duraj, Noemí García-Romero, Josefa Carrión-Navarro, Rodrigo Madurga, Ana Ortiz de Mendivil, Ricardo Prat-Acin, Lina Garcia-Cañamaque and Angel Ayuso-Sacido
Cells 2021, 10(2), 202; https://doi.org/10.3390/cells10020202 - 20 Jan 2021
13 pages, 1017 KB  
Review
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease
by Pooja S. Salvi and Robert A. Cowles
Cells 2021, 10(7), 1775; https://doi.org/10.3390/cells10071775 - 14 Jul 2021
48 pages, 5371 KB  
Review
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
by Mangesh D. Hade, Caitlin N. Suire and Zucai Suo
Cells 2021, 10(8), 1959; https://doi.org/10.3390/cells10081959 - 1 Aug 2021
19 pages, 2032 KB  
Review
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases
by Jae-Won Lee, Wanjoo Chun, Hee Jae Lee, Jae-Hong Min, Seong-Man Kim, Ji-Yun Seo, Kyung-Seop Ahn and Sei-Ryang Oh
Cells 2021, 10(4), 897; https://doi.org/10.3390/cells10040897 - 14 Apr 2021

Award Committee

Dr. Alexander E. Kalyuzhny Chairperson
University of Minnesota
Prof. Hiroshi Miyamoto
University of Rochester Medical Center
Dr. Kay-Dietrich Wagner
iBV
Dr. Francisco Rivero
University of Hull
Prof. Christian Neri

Winner

16 pages, 3080 KB  
Article
Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes
by Jinli Wang, Emily E. Bonacquisti, Adam D. Brown and Juliane Nguyen
Cells 2020, 9(3), 660; https://doi.org/10.3390/cells9030660 - 9 Mar 2020
17 pages, 1911 KB  
Article
Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness
by Zuzana Parackova, Irena Zentsova, Marketa Bloomfield, Petra Vrabcova, Jitka Smetanova, Adam Klocperk, Grigorij Mesežnikov, Luis Fernando Casas Mendez, Tomas Vymazal and Anna Sediva
Cells 2020, 9(10), 2206; https://doi.org/10.3390/cells9102206 - 29 Sep 2020
22 pages, 4622 KB  
Review
A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping
by Maria Romano, Alessia Ruggiero, Flavia Squeglia, Giovanni Maga and Rita Berisio
Cells 2020, 9(5), 1267; https://doi.org/10.3390/cells9051267 - 20 May 2020
14 pages, 835 KB  
Review
Osteoblast-Osteoclast Communication and Bone Homeostasis
by Jung-Min Kim, Chujiao Lin, Zheni Stavre, Matthew B. Greenblatt and Jae-Hyuck Shim
Cells 2020, 9(9), 2073; https://doi.org/10.3390/cells9092073 - 10 Sep 2020

Winner

Ferry Ossendorp
Leiden University Medical Center
Peter ten Dijke
Leiden University Medical Center
Dinender K. Singla
University of Central Florida
Michael Zhuo Wang
University of Kansas
Yanbo Zhang
China-Japan Union Hospital of Jilin University
Yuping Han
China-Japan Union Hospital of Jilin University
Fei Chang
The Second Hospital of Jilin University

Award Committee

Dr. Alexander E. Kalyuzhny Chairperson
University of Minnesota

Winner

Benny Abraham Kaipparettu
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA paper link: https://www.mdpi.com/2073-4409/7/3/21
Irene Meyer
Department of Cell Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam-Golm, Germany paper link: https://www.mdpi.com/2073-4409/7/4/32
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