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Osteoblast-Osteoclast Communication and Bone Homeostasis

1
Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
2
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
3
Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, MA 01605, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(9), 2073; https://doi.org/10.3390/cells9092073
Received: 25 August 2020 / Revised: 8 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Molecular Basis of Osteoclast Differentiation and Activation)
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts or osteoclasts. Alternatively, osteoblasts produce a range of different secretory molecules, including M-CSF, RANKL/OPG, WNT5A, and WNT16, that promote or suppress osteoclast differentiation and development. Osteoclasts also influence osteoblast formation and differentiation through secretion of soluble factors, including S1P, SEMA4D, CTHRC1 and C3. Here we review the current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts. View Full-Text
Keywords: bone; osteoblast; osteoclast; bone remodeling bone; osteoblast; osteoclast; bone remodeling
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MDPI and ACS Style

Kim, J.-M.; Lin, C.; Stavre, Z.; Greenblatt, M.B.; Shim, J.-H. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells 2020, 9, 2073. https://doi.org/10.3390/cells9092073

AMA Style

Kim J-M, Lin C, Stavre Z, Greenblatt MB, Shim J-H. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells. 2020; 9(9):2073. https://doi.org/10.3390/cells9092073

Chicago/Turabian Style

Kim, Jung-Min; Lin, Chujiao; Stavre, Zheni; Greenblatt, Matthew B.; Shim, Jae-Hyuck. 2020. "Osteoblast-Osteoclast Communication and Bone Homeostasis" Cells 9, no. 9: 2073. https://doi.org/10.3390/cells9092073

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