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Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells

Osteoblast-Osteoclast Communication and Bone Homeostasis

Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, MA 01605, USA
Author to whom correspondence should be addressed.
Cells 2020, 9(9), 2073;
Received: 25 August 2020 / Revised: 8 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Molecular Basis of Osteoclast Differentiation and Activation)
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts or osteoclasts. Alternatively, osteoblasts produce a range of different secretory molecules, including M-CSF, RANKL/OPG, WNT5A, and WNT16, that promote or suppress osteoclast differentiation and development. Osteoclasts also influence osteoblast formation and differentiation through secretion of soluble factors, including S1P, SEMA4D, CTHRC1 and C3. Here we review the current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts. View Full-Text
Keywords: bone; osteoblast; osteoclast; bone remodeling bone; osteoblast; osteoclast; bone remodeling
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MDPI and ACS Style

Kim, J.-M.; Lin, C.; Stavre, Z.; Greenblatt, M.B.; Shim, J.-H. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells 2020, 9, 2073.

AMA Style

Kim J-M, Lin C, Stavre Z, Greenblatt MB, Shim J-H. Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells. 2020; 9(9):2073.

Chicago/Turabian Style

Kim, Jung-Min; Lin, Chujiao; Stavre, Zheni; Greenblatt, Matthew B.; Shim, Jae-Hyuck. 2020. "Osteoblast-Osteoclast Communication and Bone Homeostasis" Cells 9, no. 9: 2073.

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