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Review

The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases

1
Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk, Cheongju 28116, Korea
2
Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Korea
3
College of Pharmacy, Chungbuk National University, Cheongju 28160, Korea
4
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Martin Thurnher
Cells 2021, 10(4), 897; https://doi.org/10.3390/cells10040897
Received: 27 March 2021 / Revised: 8 April 2021 / Accepted: 13 April 2021 / Published: 14 April 2021
Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases. View Full-Text
Keywords: macrophages; M1/M2 polarization; cytokines; acute/chronic inflammatory diseases macrophages; M1/M2 polarization; cytokines; acute/chronic inflammatory diseases
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MDPI and ACS Style

Lee, J.-W.; Chun, W.; Lee, H.J.; Min, J.-H.; Kim, S.-M.; Seo, J.-Y.; Ahn, K.-S.; Oh, S.-R. The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases. Cells 2021, 10, 897. https://doi.org/10.3390/cells10040897

AMA Style

Lee J-W, Chun W, Lee HJ, Min J-H, Kim S-M, Seo J-Y, Ahn K-S, Oh S-R. The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases. Cells. 2021; 10(4):897. https://doi.org/10.3390/cells10040897

Chicago/Turabian Style

Lee, Jae-Won, Wanjoo Chun, Hee Jae Lee, Jae-Hong Min, Seong-Man Kim, Ji-Yun Seo, Kyung-Seop Ahn, and Sei-Ryang Oh. 2021. "The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases" Cells 10, no. 4: 897. https://doi.org/10.3390/cells10040897

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