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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ras Signaling and Inhibitors: Strategies to Escape Resistance
edited by Gary Piazza
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2353 | Submission Open
Keywords: RAS; MAPK/AKT signaling; resistance; inhibitors; cancer
The Biomarkers of Oral Cancer
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2322 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; oral melanoma; surgery; combination therapy; radiation therapy; immunotherapy; drug resistance; biomarker; liquid biopsy; prognosis
(This special issue belongs to the Section Cancer Biomarkers)
Improving Outcomes in Resected Colorectal Liver Metastases: Risk-Stratified Chemotherapy and Aggressive Integration of Thermal Ablation
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2322 | Submission Open
Keywords: colorectal liver metastases (CRLM); liver resection; systemic chemotherapy; recurrence-risk stratification; carcinoembryonic antigen (CEA); carbohydrate antigen 19-9 (CA19-9); circulating tumor DNA (ctDNA); RAS mutation; thermal ablation
(This special issue belongs to the Section Cancer Metastasis)
Research and Treatment of Hepatocellular Carcinoma
edited by Chung Cheung Thomas Yau
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2058 | Submission Open
Keywords: hepatobiliary cancer; biomarker; immunotherapy; targeted therapy; combination treatments
(This special issue belongs to the Section Cancer Therapy)
Evolving Paradigms in Acute Myeloid Leukemia: From Molecular Risk to Targeted Treatment
edited by Talha Badar
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2014 | Submission Open
Keywords: acute myeloid leukemia; targeted therapy; precision medicine; menin inhibitors; venetoclax; measurable residual disease (MRD); risk stratification; allogeneic hematopoietic cell transplantation; molecular profiling; AML consolidation therapy
Overcoming Drug Resistance: Precision Medicine Drug Therapy
edited by , Yuting Huang and Raveena Manem
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1900 | Submission Open
Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system
(This special issue belongs to the Section Cancer Drug Development)
AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive and Adaptive Cancer Treatment
edited by Zhen Tian and Chaoqiong Ma
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1847 | Submission Open
Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Metabolism and Precision Oncology
edited by Rays H. Y. Jiang and Gloria C. Ferreira
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1783 | Submission Open
Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting
(This special issue belongs to the Section Cancer Pathophysiology)
Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition submission deadline 31 Oct 2026 | 1 articles | Viewed by 1554 | Submission Open
Keywords: acromegaly; adrenocorticotropic hormone; Cushing’s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment
Precision Medicine in Hematological Malignancies: Current Insights and Future Directions
edited by Giuseppe Saglio and Mohamed Yassin
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1529 | Submission Open
Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling
(This special issue belongs to the Section Cancer Therapy)
Molecular Markers and Targeted Therapy for Hepatobiliary Tumors: 2nd Edition
edited by Masaki Kuwatani
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1447 | Submission Open
Keywords: cholangiocarcinoma; hepatocellular carcinoma; molecule; gene; chemotherapy; phototherapy
The Role of Lifestyle Choices in Cancer Risk
edited by Itunu O. Sokale, Aaron P. Thrift and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1274 | Submission Open
Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention
The Next Generation of Prognosis: Novel Biomarkers in AML and MDS
edited by , Andrija Bogdanovic and Ljubomir Jakovic
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1247 | Submission Open
Keywords: acute myeloid leukemia; myelodysplastic syndrome; biomarkers; minimal residual disease; novel prognostic factors; immune-related biomarkers; molecular targets; genomics; risk stratification
(This special issue belongs to the Section Clinical Research in Cancer)
Advances in Imaging Techniques of Molecular Oncology (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1230 | Submission Open
Keywords: cancer; oncological imaging; molecular imaging; SPECT/TC; PET/CT; PET/MRI; DWI; DCE-MRI; nanotheranostics; artificial intelligence; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Prognostic Markers in Endometrial Cancer
edited by and Maciej Jóźwik
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1135 | Submission Open
Keywords: endometrial cancer; prognostic markers; overall survival; disease-free survival; genetic markers; immunohistochemical markers; immunological markers
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Biliary Tract Cancer: Multidisciplinary Perspectives in Surgery, Endoscopic Management, and Epidemiology
edited by Hiroyuki Kato
submission deadline 31 Oct 2026 | 2 articles | Viewed by 1099 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; ampullary cancer; hepatobiliary surgery; ERCP; biliary drainage; epidemiology; immunotherapy; multidisciplinary treatment; translational research
Non-Melanoma Skin Cancer: Promises and Challenges submission deadline 31 Oct 2026 | 1 articles | Viewed by 1077 | Submission Open
Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique
(This special issue belongs to the Section Cancer Therapy)
Innovations in Surgical and Management Strategies for Complex and Advanced Gastric Cancer submission deadline 31 Oct 2026 | 1 articles | Viewed by 1054 | Submission Open
Keywords: advanced gastric cancer; surgical innovation; multimodal therapy; minimally invasive gastrectomy (robotic/laparoscopic); perioperative management; immunotherapy; precision medicine; peritoneal metastasis
(This special issue belongs to the Section Clinical Research in Cancer)
Role of Myeloid Cells in the Regulation of Cancer Onset and Development
edited by Rita Campanelli
submission deadline 31 Oct 2026 | 1 articles | Viewed by 1027 | Submission Open
Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis
(This special issue belongs to the Section Tumor Microenvironment)
Feature Papers in Section "Tumor Microenvironment" (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 998 | Submission Open
Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response
(This special issue belongs to the Section Tumor Microenvironment)
Metabolomic Biomarkers for Cancers
edited by and Burak Derkuş
submission deadline 31 Oct 2026 | 1 articles | Viewed by 919 | Submission Open
Keywords: metabolomics; lipidomics; fluxomics; cancer biomarkers; precision oncology; biofluids; exosomes; organoids; extracellular vesicles; multi-omics integration; personalized medicine
(This special issue belongs to the Section Cancer Biomarkers)
Mechanisms of Resistance and Response to Immune Checkpoint Inhibitors in Squamous Cell Carcinomas
edited by and
submission deadline 31 Oct 2026 | 2 articles | Viewed by 897 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy resistance; squamous cell carcinoma; tumor microenvironment; tumor–immune interactions; immune evasion mechanisms; biomarkers of immunotherapy response; tumor–host interactions neuro-immune signaling; tumor metabolism and immunity
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research
(This special issue belongs to the Section Cancer Informatics and Big Data)
Biomarkers in the Management of Lung Cancer
edited by Ole Hilberg
submission deadline 31 Oct 2026 | 1 articles | Viewed by 834 | Submission Open
Keywords: lung cancer; biomarker; precision medicine
(This special issue belongs to the Section Cancer Biomarkers)
Metabolic Reprogramming in Cancer: Implications for Tumor Progression, Metastasis, Immune Evasion and Therapy Resistance
edited by and Bramanandam Manavathi
submission deadline 31 Oct 2026 | Viewed by 742 | Submission Open
Keywords: cancer and mitochondrial metabolism; metabolic reprogramming; glutamine metabolism; tumor microenvironment; metabolic plasticity; oxidative phosphorylation; drug resistance; immune evasion; cancer metastasis; therapeutic metabolic targeting
(This special issue belongs to the Section Molecular Cancer Biology)
Current Treatment Options for Rectal Cancer
edited by Jesús Pedro Paredes Cotoré
submission deadline 31 Oct 2026 | 1 articles | Viewed by 711 | Submission Open
Keywords: rectal cancer; therapeutic approach; rectal surgery; neoadjuvant treatment; radiotherapy; immunotherapy; chemotherapy; quality of life
(This special issue belongs to the Section Cancer Therapy)
Molecular Imaging in Oncology: Recent Advances (2nd Edition) submission deadline 31 Oct 2026 | 1 articles | Viewed by 698 | Submission Open
Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry
(This special issue belongs to the Section Cancer Therapy)
Novel Diagnostic and Therapeutic Approaches in Hepato-Pancreato-Biliary Cancer
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 683 | Submission Open
Keywords: cholangiocarcinoma; intrahepatic; resection; targeted therapy; chemotherapy; outcomes
(This special issue belongs to the Section Cancer Therapy)
Oral Potentially Malignant Disorders and Oral Cavity Cancer: 2nd Edition
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 661 | Submission Open
Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine
(This special issue belongs to the Section Cancer Therapy)
Clinical Research in Gynecological Cancers
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 628 | Submission Open
Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery
(This special issue belongs to the Section Clinical Research in Cancer)
From Metronomic Chemotherapy to Time-Optimized Cancer Treatments
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 625 | Submission Open
Keywords: metronomic chemotherapy; time-dependent treatment; chemotherapy; immunotherapy; pharmacokinetics; pharmacodynamics
Pathological and Molecular Insights into Urothelial Carcinoma
edited by Gabriela M. Quiroga-Garza, and Dimitrios Korentzelos
submission deadline 31 Oct 2026 | 1 articles | Viewed by 598 | Submission Open
Keywords: bladder cancer; urothelial carcinoma; diagnosis; histopathology; molecular; genomics; biomarkers; prognosis; immunotherapy
The Development and Application of Imaging Biomarkers in Cancer: 2nd Edition
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 573 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
The Role of Nutrients in Cancer Progression
edited by
submission deadline 31 Oct 2026 | Viewed by 559 | Submission Open
Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Pathophysiology)
Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy
edited by and
submission deadline 31 Oct 2026 | Viewed by 532 | Submission Open
Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial–mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment of Oral Cancer
edited by Zhigang Cai and
submission deadline 31 Oct 2026 | Viewed by 466 | Submission Open
Keywords: oral cancer; surgical treatment; neck dissection; reconstructive surgery; free flap; transoral robotic surgery (TORS); complications; salvage surgery; quality of life; multidisciplinary management
(This special issue belongs to the Section Cancer Therapy)
Clinical Benefit of Hybrid PET/MRI Molecular Imaging in Oncology
edited by Ana María García-Vicente and
submission deadline 31 Oct 2026 | Viewed by 457 | Submission Open
Keywords: PET/MRI; hybrid imaging; gynecological cancer; prostate cancer; glioma; brain metastases; brain meningioma; sarcoma; liver cancer; hepato-biliary cancer; pancreatic cancer; rectal cancer; breast cancer
(This special issue belongs to the Section Clinical Research in Cancer)
Targeted and Translational Therapies in Genitourinary Cancers: Addressing Unmet Clinical Needs Through Organ-Specific Innovation submission deadline 31 Oct 2026 | Viewed by 436 | Submission Open
Keywords: genitourinary cancer; therapeutic resistance; precision oncology; biomarker-guided therapy; antibody-drug conjugates; prostate cancer; renal cell carcinoma; bladder cancer; testicular cancer; novel modalities; organ-specific strategies
(This special issue belongs to the Section Cancer Therapy)
Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes
edited by
submission deadline 31 Oct 2026 | Viewed by 427 | Submission Open
Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Signaling Networks and Systems Biology in Cancer submission deadline 31 Oct 2026 | Viewed by 417 | Submission Open
Keywords: cancer signaling; immuno-oncology; cancer nanotechnology; AI/ML in cancer; systems oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)
edited by and
submission deadline 31 Oct 2026 | Viewed by 410 | Submission Open
Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance
(This special issue belongs to the Section Cancer Therapy)
Non-Pharmacological Interventions in Oncology Supportive and Palliative Care
edited by
submission deadline 31 Oct 2026 | Viewed by 408 | Submission Open
Keywords: integrative palliative care; integrative therapies; non-pharmacological therapies; symptom management; palliative care; supportive care; massage; acupuncture; tai chi; virtual reality
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities
edited by , Giacomo Miserocchi and
submission deadline 31 Oct 2026 | Viewed by 405 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; tumor–stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models
(This special issue belongs to the Section Tumor Microenvironment)
Opportunities and Challenges for Effective Cancer Immunotherapies
edited by
submission deadline 31 Oct 2026 | Viewed by 363 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis
edited by
submission deadline 31 Oct 2026 | Viewed by 351 | Submission Open
Keywords: CTCs; liquid biopsy; metastasis; biomarkers
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies submission deadline 31 Oct 2026 | Viewed by 343 | Submission Open
Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery
(This special issue belongs to the Section Cancer Therapy)
Advances in Skull Base Tumor Surgery: From Diagnosis to Minimally Invasive Treatment
edited by James P Chandler and
submission deadline 31 Oct 2026 | 1 articles | Viewed by 340 | Submission Open
Keywords: skull base tumors; minimally invasive neurosurgery; advanced imaging; molecular diagnostics; cranial base reconstruction; targeted therapies; radiosurgery; precision medicine
(This special issue belongs to the Section Clinical Research in Cancer)
Targeting the Hypoxic Axis: HIF Signaling and Therapeutic Resistance in the Tumor Microenvironment
edited by and
submission deadline 31 Oct 2026 | Viewed by 340 | Submission Open
Keywords: hypoxia-inducible factors (HIFs); tumor microenvironment; hypoxia signaling; therapeutic resistance; cancer metabolism; angiogenesis; immune evasion; targeted cancer therapy
(This special issue belongs to the Section Tumor Microenvironment)
Genetic Disorders and Cancer Susceptibility: Molecular Mechanisms, Risk Assessment and Targeted Therapies
edited by Silmara de Lima
submission deadline 31 Oct 2026 | Viewed by 338 | Submission Open
Keywords: neurofibromatosis type-1; optic pathway glioma; retinal ganglion cell survival; myelination; vision loss; targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Sarcoma Biology and Therapeutics: From Mechanisms to Novel Treatments
edited by
submission deadline 31 Oct 2026 | Viewed by 322 | Submission Open
Keywords: sarcoma; bone and soft tissue sarcoma; tumor biology; molecular mechanisms; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening
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