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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiotherapy for Sarcomas and Connective Tissue Tumors
edited by Kevin X. Liu and Fantine N. Giap
submission deadline 31 Mar 2027 | Viewed by 223 | Submission Open
Keywords: radiotherapy; sarcoma; connective tissue tumors; proton radiotherapy; oligometastatic disease; palliative radiotherapy; radiation toxicity
Advanced Imaging and AI in Head and Neck Oncology
edited by
submission deadline 31 Mar 2027 | Viewed by 223 | Submission Open
Keywords: head and neck cancer; artificial intelligence; machine learning; advanced imaging; biomarker development; multimodal data integration; precision oncology; treatment toxicity; large language model; radiomics
Papillomaviruses and Cancer
edited by Peter Angeletti
submission deadline 31 Mar 2027 | Viewed by 203 | Submission Open
Keywords: cervical cancer; oral cancer; squamous cell carcinoma; human papillomavirus (HPV); inflammation; microbiome; biomarkers; cancer therapy
(This special issue belongs to the Section Infectious Agents and Cancer)
Robotic Surgery in Oesophagogastric Cancer
edited by Steve Hornby and Simon Higgs
submission deadline 31 Mar 2027 | Viewed by 197 | Submission Open
Keywords: oesophagogastric cancer; robotic surgery; minimally invasive surgery; robotic oesophagectomy; robotic gastrectomy; clinical outcomes; surgical training; digital surgical systems; intelligent surgery; implementation science
(This special issue belongs to the Section Methods and Technologies Development)
Advanced Diagnostics and Optical Imaging Technologies in Cancer Research (2nd Edition)
edited by Vlad Mihai Voiculescu
submission deadline 31 Mar 2027 | Viewed by 182 | Submission Open
Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies
Pregnancy and Breast Cancer: Distinguishing Breast Cancer During Pregnancy, Post-Partum Breast Cancer (PPBC), and the Impact of Breastfeeding
edited by Doris Germain
submission deadline 31 Mar 2027 | Viewed by 172 | Submission Open
Keywords: post-partum breast cancer; pregnancy; mammary gland involution; breastfeeding; lactation; parity; SEMA7A; PAPP-A; COX2
Clinical Research in Renal Cell Carcinoma: Advancements in Biomarkers submission deadline 31 Mar 2027 | Viewed by 153 | Submission Open
Keywords: biomarkers; KIM-1; radiomics
(This special issue belongs to the Section Cancer Biomarkers)
Innovative Clinical Trial Designs Shaping the Future of Cancer Research submission deadline 31 Mar 2027 | Viewed by 144 | Submission Open
Keywords: clinical trial design; precision oncology; early drug development; biomarkers; artificial intelligence
(This special issue belongs to the Section Clinical Research in Cancer)
The Molecular Pathology of Breast Cancer: Insights into Tumor Biology, Prognostic Biomarkers, and Potential Therapeutic Targets
edited by and Gregor Krings
submission deadline 31 Mar 2027 | Viewed by 139 | Submission Open
Keywords: breast cancer; molecular pathology; tumor biology; biomarkers; ESR1; HER2 low and ultralow; triple negative breast cancer; lobular carcinoma; phyllodes tumors; breast salivary gland-like tumors
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Medical Imaging for Cancer Diagnosis and Management
edited by
submission deadline 31 Mar 2027 | Viewed by 129 | Submission Open
Keywords: medical imaging; cancer diagnosis; deep learning; image segmentation; artificial intelligence
Screening and Early Detection in Urological Oncology
edited by , and Lukasz Dolowy
submission deadline 31 Mar 2027 | Viewed by 128 | Submission Open
Keywords: screening; prostate cancer; bladder cancer; testicular cancer; oncology; early detection; algorithm; artificial intelligence
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Proteogenomics of Lung, Thoracic and Breast Cancers: Enter the Era of Precision Oncology submission deadline 31 Mar 2027 | Viewed by 116 | Submission Open
Keywords: thoracic cancers; breast cancer; proteogenomics; precision oncology; multi-omics; biomarkers; liquid biopsy; spatial omics; single cell omics; tumor microenvironment; artificial intelligence
(This special issue belongs to the Section Molecular Cancer Biology)
Psychosocial Approaches and Interventions to Improve Quality of Life and Cancer Outcomes submission deadline 31 Mar 2027 | Viewed by 111 | Submission Open
Keywords: psycho-oncology; quality of life; cancer care; psychosocial interventions; patient-reported outcomes; cancer survivorship; emotional well-being; supportive care; cancer outcomes; psychosocial adjustment
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Oncogenic and Metabolic Signaling Pathways Within the Tumor Microenvironment
edited by and Pratibha Pandey
submission deadline 31 Mar 2027 | Viewed by 103 | Submission Open
Keywords: tumor microenvironment; signaling pathways; metabolic reprogramming; antitumor immunity; multitargeted therapy
(This special issue belongs to the Section Tumor Microenvironment)
Advancements in Child, Adolescent, and Young Adult Cancer Survivorship (2nd Edition) submission deadline 31 Mar 2027 | Viewed by 93 | Submission Open
Keywords: late effects; chronic diseases; prevention; rehabilitation; remediation; psychosocial factors; quality of life; lifestyles; surveillance; survivors; educational strategies
(This special issue belongs to the Section Pediatric Oncology)
Advances in B-Cell Lymphoma: From Diagnostics to Cure (2nd Edition)
edited by and Megan E. Melody
submission deadline 31 Mar 2027 | Viewed by 89 | Submission Open
Keywords: B-cell lymphoma; treatment; molecular profiling; immunotherapies; cellular therapies
(This special issue belongs to the Section Cancer Therapy)
Large Language Models and Agentic AI in the Management of Thoracic and Abdominal Malignancies: From Diagnosis to Survivorship
edited by
submission deadline 31 Mar 2027 | Viewed by 81 | Submission Open
Keywords: large language models; agentic AI; thoracic malignancies; abdominal malignancies; clinical decision support; electronic health records; patient education and survivorship; clinical trial matching; AI safety and evaluation; privacy-preserving deployment
PD-(L)1-Centered Immune Combination Therapy: Synergistic Mechanisms and Clinical Breakthroughs
edited by
submission deadline 31 Mar 2027 | Viewed by 74 | Submission Open
Keywords: PD-1/PD-L1 blockade; combination immunotherapy; tumor microenvironment; immune resistance; cold-to-hot tumor conversion
Improving Lung Cancer Outcomes Through Innovation in Screening and Early Detection
edited by Dan J. Raz
submission deadline 31 Mar 2027 | Viewed by 73 | Submission Open
Keywords: lung cancer screening; early lung cancer detection; low-dose CT; artificial intelligence; liquid biopsy; biomarkers; radiomics; risk stratification; health equity; implementation science
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Computational Innovations Enabling Precision Oncology
edited by and
submission deadline 31 Mar 2027 | Viewed by 73 | Submission Open
Keywords: bioinformatics; genomics; proteomics; microbiomics; metabolomics; multi-omics; machine learning; deep learning; medical informatics; drug discovery
Emerging Concepts in HER2 Breast Cancer: From Resistance Mechanisms to Next-Generation Therapies
edited by Xiaoting Zhang
submission deadline 31 Mar 2027 | Viewed by 61 | Submission Open
Keywords: HER2; breast cancer; treatment resistance; tumor microenvironment; immune evasion; epigenetics; transcriptional regulation; biomarkers; precision oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer Cell Metabolism and Tumor Microenvironment Remodeling
edited by
submission deadline 31 Mar 2027 | Viewed by 60 | Submission Open
Keywords: metabolic reprogramming; tumor microenvironment; immunometabolism; cell death; single-cell and spatial multi-omics; oncolytic virotherapy; therapy resistance
(This special issue belongs to the Section Tumor Microenvironment)
Precision Molecular Diagnostics and Biomarker-Driven Pathology in Breast and Gynecologic Cancers
edited by
submission deadline 31 Mar 2027 | Viewed by 56 | Submission Open
Keywords: tumor genomics; molecular diagnosis; predictive biomarkers; targeted therapies; antibody–drug conjugates; homologous recombination deficiency; breast cancer; gynecologic cancer
Clinical Treatment of Pediatric Solid Tumors
edited by Sara Claire Horton
submission deadline 31 Mar 2027 | Viewed by 34 | Submission Open
Keywords: pediatric solid tumor; pediatric radiation therapy; pediatric oncology; pediatric sarcoma; pediatric liver tumor; pediatric renal tumor; pediatric surgical oncology
(This special issue belongs to the Section Pediatric Oncology)
Cellular Plasticity in Cancer
edited by Farzana Alam
submission deadline 31 Mar 2027 | Viewed by 32 | Submission Open
Keywords: cellular plasticity; tumor heterogeneity; epithelial–mesenchymal transition; cancer stem cells; cell fate reprogramming; tumor microenvironment; therapy resistance; metastasis; single-cell omics; cancer evolution
(This special issue belongs to the Section Molecular Cancer Biology)
From Bench to Bedside: The Evolving Role of Gene and Cell Therapy in Oncology
edited by Jacquelyn J. Bower
submission deadline 31 Mar 2027 | Viewed by 29 | Submission Open
Keywords: cancer gene therapy; cell therapy; adeno-associated virus; lentivirus; immunotherapy; oncolytic viruses; cancer stem cells; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Screening and Surveillance of Gastrointestinal and Pancreatic Cancers: 2nd Edition
edited by and Darina Kohoutová
submission deadline 31 Mar 2027 | Viewed by 18 | Submission Open
Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Nanotechnology and Smart Biomaterials in Cancer Diagnosis and Therapy
edited by Giulia Mesiano
submission deadline 31 Mar 2027 | Viewed by 15 | Submission Open
Keywords: nanotechnology; smart biomaterials; nanomedicine; targeted drug delivery; theranostics; tumor microenvironment; 3D tumor models; ECM-mimicking scaffolds; organ-on-chip; microfluidics; precision oncology; clinical translation
(This special issue belongs to the Section Methods and Technologies Development)
The Power of Combination: Optimizing Radio-Chemotherapeutic Synergy in Multimodal Oncology
edited by , Chittalsinh Raulji and Bhavina Sharma
submission deadline 31 Mar 2027 | Viewed by 9 | Submission Open
Keywords: radio-chemotherapy; multimodal oncology; radioprotectors, radiomitigators; radiosensitizers; tumor microenvironment; immunomodulation; chemo-radiation biology; radionuclide therapy
(This special issue belongs to the Section Cancer Therapy)
Stereotactic Radiosurgery for Brain Metastases: Evidence for Daily Practice
edited by
submission deadline 31 Mar 2027 | Viewed by 2 | Submission Open
Keywords: brain metastases; stereotactic radiosurgery (SRS); stereotactic radiotherapy (SRT); gamma knife radiosurgery; whole-brain radiotherapy (WBRT); systemic therapy; targeted therapy; immune checkpoint inhibition; radioimmunotherapy; treatment sequencing; breast cancer; non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); melanoma; renal cell carcinoma; multiple brain metastases; large brain metastases; hypofractionated SRS; adaptive radiosurgery; perioperative SRS; resection cavity radiosurgery; reirradiation; salvage radiosurgery; adverse radiation effects; radiation necrosis; immunobiology; neuroimaging; response assessment; neurocognition; quality of life; treatment platforms; patient selection; referral pathways; access to care
Targeting JAK/STAT Signaling Pathways for Studying Cancer Pathogenesis, Discovering Cancer Markers, Developing Therapies, and Bypassing Drug Resistance
edited by
submission deadline 1 Apr 2027 | Viewed by 363 | Submission Open
Keywords: JAK-STAT; cancer markers; drug resistance; tumoroids; CAR T-cell therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Neoadjuvant and Perioperative Therapy for Lung Cancer
edited by Erminia Massarelli
submission deadline 1 Apr 2027 | Viewed by 111 | Submission Open
Keywords: neoadjuvant therapy; perioperative therapy; lung cancer; immunotherapy; immune checkpoint inhibitors; targeted therapy; pathological complete response; event-free survival; biomarkers; circulating tumor DNA
(This special issue belongs to the Section Cancer Therapy)
Updates on Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes
edited by and Xiaoqing Cathy Cheng
submission deadline 1 Apr 2027 | Viewed by 99 | Submission Open
Keywords: tumor hypoxia; hypoxia-targeted therapy; HIF signaling; therapeutic resistance; tumor microenvironment; cancer metabolism; hypoxia-activated prodrugs; combination therapy; precision oncology
Complications After Gastrectomy for Cancer
edited by , Simone Giacopuzzi and Felix Berlth
submission deadline 1 Apr 2027 | Viewed by 36 | Submission Open
Keywords: gastric cancer; gastrectomy; surgical oncology; postoperative complications; postoperative morbidity; anastomotic leakage; duodenal stump leakage; minimally invasive surgery; robotic surgery; perioperative care; prehabilitation; enhanced recovery after surgery; failure to rescue; nutritional outcomes; quality of life; multicenter registries; clinical decision support; postoperative bleeding; cardiopulmonary complications; delayed gastric emptying; postoperative nutritional impairment
Advances in Immunotherapy and Targeted Therapy for Lung Cancer
edited by
submission deadline 3 Apr 2027 | 1 articles | Viewed by 1176 | Submission Open
Keywords: thoracic oncology; immune checkpoint inhibitor; antibody-drug conjugate; bispecific antibody; targeted therapy; precision medicine; combination therapy; biomarker
(This special issue belongs to the Section Cancer Therapy)
Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition
edited by
submission deadline 9 Apr 2027 | 4 articles | Viewed by 17017 | Submission Open
Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives submission deadline 10 Apr 2027 | 2 articles | Viewed by 2127 | Submission Open
Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship
(This special issue belongs to the Section Clinical Research in Cancer)
Robotic Versus Laparoscopic Surgery for Colorectal Cancer
edited by Richard Garfinkle and Nicholas P. McKenna
submission deadline 10 Apr 2027 | 2 articles | Viewed by 1037 | Submission Open
Keywords: colon cancer; rectal cancer; colorectal cancer; robotic surgery; laparoscopic surgery; transanal surgery; minimally invasive surgery
(This special issue belongs to the Section Methods and Technologies Development)
Flow Cytometry and Molecular Studies in Hematological Malignancies
edited by Kirill A. Lyapichev
submission deadline 10 Apr 2027 | Viewed by 588 | Submission Open
Keywords: flow cytometry; molecular studies; hematological neoplasms; lymphoma; leukemia
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Lung Cancer Treatment Strategies submission deadline 15 Apr 2027 | 5 articles | Viewed by 6180 | Submission Open
Keywords: lung cancer; immunotherapy; immune checkpoint inhibitors; chemoimmunotherapy; target therapy; biomarkers; non-small cell lung cancer; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Rare Genitourinary Cancers submission deadline 15 Apr 2027 | 2 articles | Viewed by 2690 | Submission Open
Keywords: rare genitourinary tumors; penile cancer; testicular cancer; urethral cancer; adrenal cancer; variant histology; upper tract urothelial carcinoma; extramammary Paget’s disease; urologic oncology; rare cancers
(This special issue belongs to the Section Clinical Research in Cancer)
Pain Management and Palliative Care for Patients with Advanced Cancer
edited by Magdalena Anitescu
submission deadline 15 Apr 2027 | Viewed by 166 | Submission Open
Keywords: interventional pain procedures; cancer-related pain; radiological images in spine metastases; palliative surgical interventions; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Cellular Pharmacology for Cancer Therapy: Drug Response, Resistance and Precision Treatment Strategies
edited by and Mitesh Patel
submission deadline 15 Apr 2027 | Viewed by 79 | Submission Open
Keywords: cellular pharmacology; cancer therapy; drug response; drug resistance; precision oncology; targeted therapy; combination therapy; tumour microenvironment; pharmacogenomics; anticancer drug development
(This special issue belongs to the Section Cancer Drug Development)
Biomarker-Driven Treatment in Breast Cancer: From Genomic Profiling to Antibody–Drug Conjugates
edited by and Caterina Marchiò
submission deadline 15 Apr 2027 | Viewed by 44 | Submission Open
Keywords: breast cancer; personalized treatment; risk-adapted treatment strategies; molecular diagnostics; plasticity; comprehensive genomic profiling
(This special issue belongs to the Section Cancer Biomarkers)
Precision Medicine and Therapeutic Innovation in Pancreatic Cancer
edited by Ben George
submission deadline 16 Apr 2027 | Viewed by 68 | Submission Open
Keywords: pancreatic cancer; KRAS; targeted therapy; immunotherapy; surgery; clinical trial; genomic profiling; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Advances in Precision Medicine for Chronic Lymphocytic Leukemia
edited by
submission deadline 18 Apr 2027 | Viewed by 69 | Submission Open
Keywords: CLL; precision medicine; patient comorbidities; logistics; patient preference
(This special issue belongs to the Section Cancer Therapy)
Pain and Palliative Care in Patients with Cancers submission deadline 20 Apr 2027 | 3 articles | Viewed by 4043 | Submission Open
Keywords: cancer pain; palliative care; opioid tolerance
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Emerging Biomarkers for Immune Checkpoint Inhibitor Sensitivity and Resistance in Non-Small-Cell Lung Cancer
edited by Minglei Zhuo
submission deadline 20 Apr 2027 | Viewed by 576 | Submission Open
Keywords: non-small-cell lung cancer; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers; tumor microenvironment; PD-L1; circulating biomarkers; microbiota; translational oncology; combination strategies
(This special issue belongs to the Section Cancer Biomarkers)
Computational Oncology: Machine Learning, Digital Biomarkers, and Clinical Decision Support submission deadline 20 Apr 2027 | Viewed by 251 | Submission Open
Keywords: computational oncology; machine learning; deep learning; digital biomarkers; clinical decision support; precision oncology; explainable artificial intelligence; radiomics; multi-omics integration; cancer diagnosis and prognosis
(This special issue belongs to the Section Cancer Informatics and Big Data)
Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer
edited by and
submission deadline 25 Apr 2027 | 1 articles | Viewed by 1822 | Submission Open
Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)
(This special issue belongs to the Section Methods and Technologies Development)
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