Special Issue "Multiple Myeloma: Targeted Therapy and Immunotherapy"
Deadline for manuscript submissions: closed (31 August 2021).
Interests: multiple myeloma; Waldenstrom; immune therapy; proteasome; transplantation
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A cure for multiple myeloma, the second most common hematologic malignancy, remains elusive. Dysregulation of the immune system is a hallmark of this disease both at onset and during progression. Immune therapy — initially in the form of maintenance interferon therapy — has been around for at least four decades. Nevertheless, a highly effective therapy— at least in part — through the rectification of the compromised immune component of the bone marrow niche has gained general acceptance in the form of proteasome inhibitors, immune-modulatory agents (IMIDs), and more recently, monoclonal antibodies.
The further development of immune-based therapies has recently increased the clinical options for relapsed and/or refractory myeloma, which not only include “bare” monoclonal antibodies (alone or in combination), but also promising antibody–drug conjugates, bispecific antibodies, and bispecific T-cell engagers. Furthermore, chimeric antigen T-cell therapy is fast gaining approval in the treatment of multiple myeloma. Inhibition of the immune checkpoint blockade in relapsed myeloma has been hindered by unexpected toxicity. If the toxic side effect problem can be solved, the substantial antimyeloma activity seen in early trials may also provide breakthroughs. It is also expected that these novel therapeutics — in the field of newly diagnosed disease — will lead to further improvements in clinical results and eventually to a cure in a substantial number of patients.
This Special Issue will highlight one of the most rapidly developing fields of hematological cancer therapy, which may also serve as a model for other areas. Basic and clinical aspects will be covered to increase our understanding of targeted and immunotherapy in myeloma to facilitate progress from the bench to the bedside.
Dr. Gabor Mikala
Manuscript Submission Information
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