Topical Collection "Germ Cell Tumors"
A topical collection in Cancers (ISSN 2072-6694).
Interests: urological tumors; molecular pathology; tumor markers; epigenetics; epitranscriptomics; epi-drugs
Interests: Germ cell tumors, fertility, disorders of sex development; (Molecular) Biomarkers; Treatment sensitivity and resistance
Interests: uropathology; cancer biomarkers; epigenetics
Special Issues and Collections in MDPI journals
Malignant germ cell tumors (GCTs) are among the most common cancers afflicting young adults. Despite their high curability, incidence is rising as well as disease burden, owing to chemo- and radiotherapy-induced morbidity. Moreover, a restricted, but significant, number of patients develop therapy-resistance, entailing poor prognosis, and the underlying mechanisms are mostly unknown. GCTs are archetypes of morphological heterogeneity, although the genetic background is rather similar. Hence, improved understanding of immunological signatures, molecular pathways and epigenetic alterations underlying the pathology is mandatory. Finally, the limitations of “classical” biomarkers (AFP, betaHCG) have stimulated the search for novel disease biomarkers, allowing for improved disease monitoring and refinement of therapeutic strategies, especially for the most aggressive subtypes.
Thus, in this Special Issue, we aim to cover all relevant aspects of malignant GCT encompassing basic, preclinical, and clinical research in this challenging tumor model.
Prof. Carmen Jerónimo
Prof. Leendert H.J. Looijenga
Prof. Rui Henrique
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- similarities and differences between gonadal and extragonadal GCT
- advances in pathological assessment of GCT
- epigenetics and epigenomics of GCT/subtyping/molecular profiling of GCT
- micro-environment and selection
- GCT tumor microenvironment/GCT cancer stem cells
- signaling pathways in GCT
- biomarkers for detection and monitoring of GCT
- GCT tumorigenesis, heterogeneity and metastasis
- preclinical models
- animal models of GCT
- in vitro models of GCT
- clinical aspects
- imaging of GCT
- drug delivery to GCT cells
- molecular targeted therapies for GCT
- precision medicine for GCT
- innovative therapeutic strategies for GCT