Germ Cell Tumors
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 16 October 2024 | Viewed by 52564
Special Issue Editors
RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal
Porto Comprehensive Cancer Center (Porto.CCC), School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal
Interests: epigenome of tumor cells; the identification of functional changes involved in cell epigenetic homeostasis breakdown; epigenetic biomarkers
Special Issues, Collections and Topics in MDPI journals
Interests: Germ cell tumors, fertility, disorders of sex development; (Molecular) Biomarkers; Treatment sensitivity and resistance
Interests: uropathology; cancer biomarkers; epigenetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Malignant germ cell tumors (GCTs) are among the most common cancers afflicting young adults. Despite their high curability, incidence is rising as well as disease burden, owing to chemo- and radiotherapy-induced morbidity. Moreover, a restricted, but significant, number of patients develop therapy-resistance, entailing poor prognosis, and the underlying mechanisms are mostly unknown. GCTs are archetypes of morphological heterogeneity, although the genetic background is rather similar. Hence, improved understanding of immunological signatures, molecular pathways and epigenetic alterations underlying the pathology is mandatory. Finally, the limitations of “classical” biomarkers (AFP, betaHCG) have stimulated the search for novel disease biomarkers, allowing for improved disease monitoring and refinement of therapeutic strategies, especially for the most aggressive subtypes.
Thus, in this Special Issue, we aim to cover all relevant aspects of malignant GCT encompassing basic, preclinical, and clinical research in this challenging tumor model.
Prof. Carmen Jerónimo
Prof. Leendert H.J. Looijenga
Prof. Rui Henrique
Collection Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pathogenesis
- similarities and differences between gonadal and extragonadal GCT
- advances in pathological assessment of GCT
- epigenetics and epigenomics of GCT/subtyping/molecular profiling of GCT
- micro-environment and selection
- GCT tumor microenvironment/GCT cancer stem cells
- signaling pathways in GCT
- biomarkers for detection and monitoring of GCT
- GCT tumorigenesis, heterogeneity and metastasis
- preclinical models
- animal models of GCT
- in vitro models of GCT
- clinical aspects
- imaging of GCT
- drug delivery to GCT cells
- molecular targeted therapies for GCT
- precision medicine for GCT
- innovative therapeutic strategies for GCT
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.