Special Issue "Advances in Cancer Stem Cell Research"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 86041
Interests: cancer stem cells; tumor microenvironment; angiogenesis; cancer biology; growth factors and cytokines; drug delivery systems; targeting cancer; liposomes; drug screening; self-organizing map
Although cancer stem cells (CSCs) and their significant importance have frequently been described during the last decade, they have not been sufficiently analyzed, mainly due to the small population in cancer tissues and the difference depending on patients.
To date, CSCs are believed responsible for intratumoral heterogeneity due to plasticity, which should be controlled by epigenetic and genetic changes.
The effects on the changes are described as the tumor microenvironment. The induction of CSCs from normal cells is yet unknown, but suspected to be triggered by chronic condition such as inflammation, which would provide the microenvironment for the development of CSCs. In fact, Wnt/β-Catenin and TGF-β/Smad signaling pathways are thought to crosstalk with the NF-κB signaling pathway. Hedgehog and Notch signaling pathways are also considered to be involved in inflammatory sequences.
On the other hand, these signaling pathways are again considered significant to maintain CSCs in tumor tissues composing the niche. The factors involved in the niche might be traced to hypoxia, Nodal/Cripto-1 and the metabolome specific to CSCs. Investigation of the niche will reveal new CSC markers, which will be the good targets to treat CSCs.
The ecosystem of tumors surrounded by the cancer associated fibroblasts, macrophages, and adipocytes should be closely linked with the epithelial–mesenchymal transition, angiogenesis and so on.
This Special Issue will highlight the recent advances of the biology of cancer stem cells and their niche related significant events.
Prof. Dr. Masaharu Seno
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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- cancer heterogeneity
- plasticity, epigenetics
- epithelial–mesenchymal transition