Special Issue "Targeting Bone Metastasis in Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 April 2018).
Interests: cancer bone metastasis; cancer-induced bone pain; cancer-associated cachexia
Once cancer metastasizes to bone, the mortality rate of patients increases significantly. It has been appreciated that host microenvironment actively influences cancer cells, leading to progressive and incurable bone metastasis, full understanding of the mechanisms involved in bone metastasis remains unknown. It has been suggested that the interactions among cancer cells, tumor microenvironment (e.g., immune cells, cells involved in bone remodeling, stromal fibroblasts), and factors produced by these host cells (e.g., growth factors, cytokines, chemokines, microRNAs) control bone metastatic process. Greater understanding of these interactions will therefore lead us to a better understanding of bone metastatic progression and enable us to pursue innovative and important directions toward treatments.
We invite authors to submit original articles and review articles that seek to explore the interaction between bone metastatic cancer cells and their microenvironment. We are particularly interested in articles describing new insights into the function and morphology of the microenvironment that controls bone metastatic progression.
Potential topics include, but are not limited to:
- Identification of factors derived from the tumor microenvironment which influence bone metastatic process
- The roles of the bone marrow microenvironment in the progression of bone metastasis
- The participation of the nervous system in the development of bone metastasis
- Innovative model systems to test and understand the molecular mechanisms of bone metastasis
- Status of biomaterial-based approaches to reveal the mechanisms of bone metastasis
- The gap between major clinical problems and basic research in bone metastasis
- The current situation of treatment for bone metastasis
Dr. Yusuke Shiozawa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.