Emerging and Established Models of Bone Metastasis
AbstractMetastasis is the leading cause of cancer-related death and drives patient morbidity as well as healthcare costs. Bone is the primary site of metastasis for several cancers—breast and prostate cancers in particular. Efforts to treat bone metastases have been stymied by a lack of models to study the progression, cellular players, and signaling pathways driving bone metastasis. In this review, we examine newly described and classic models of bone metastasis. Through the use of current in vivo, microfluidic, and in silico computational bone metastasis models we may eventually understand how cells escape the primary tumor and how these circulating tumor cells then home to and colonize the bone marrow. Further, future models may uncover how cells enter and then escape dormancy to develop into overt metastases. Recreating the metastatic process will lead to the discovery of therapeutic targets for disrupting and treating bone metastasis. View Full-Text
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Jinnah, A.H.; Zacks, B.C.; Gwam, C.U.; Kerr, B.A. Emerging and Established Models of Bone Metastasis. Cancers 2018, 10, 176.
Jinnah AH, Zacks BC, Gwam CU, Kerr BA. Emerging and Established Models of Bone Metastasis. Cancers. 2018; 10(6):176.Chicago/Turabian Style
Jinnah, Alexander H.; Zacks, Benjamin C.; Gwam, Chukwuweike U.; Kerr, Bethany A. 2018. "Emerging and Established Models of Bone Metastasis." Cancers 10, no. 6: 176.
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