Pleural Cavity Tumor Microenvironment: Primary and Metastatic Tumors

Dear Colleagues,

Pleural effusion is a major diagnostic and therapeutic problem with more than 1.5 million patients suffering from this condition in the United States every year. Cancer is one of the commonest etiologies of pleural effusion, and both metastatic diseases and primary tumors show poor prognosis and urge for therapeutic advance. Immunotherapy has demonstrated promising results in various forms of cancer, and its utility in pleural diseases is under investigation. Furthermore, basic, and translational studies are trying to elucidate the role of the numerous factors of the tumor microenvironment, like inflammatory cells, vascular bed, extracellular matrix, extracellular vesicles, neural fibers in various forms of cancer, including the pleural cavity, which has unique physiological characteristics.

This Special Issue aims to gather all recent development in the tumor microenvironment of the pleural cavity, in terms of basic and translational science, but also of clinical and therapeutic advance.

Dr. Georgia Karpathiou
Prof. Dr. Marios Froudarakis
Guest Editors

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