Special Issue "Protein Kinases and Cancers"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 February 2019)
Prof. Dr. Richard Bayliss
Dr. Sharon Yeoh
School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
Interests: Enzymology, enzyme kinetics
The regulation of protein function through phosphorylation is a major component of cellular signalling pathways, such as those that govern cell cycle progression, control gene expression or determine whether a cell survives or dies. In humans, the phosphorylation of proteins is catalysed by over 500 protein kinases, most of which specifically modify either Ser/Thr or Tyr side chains. Their catalytic activities are regulated through molecular mechanisms that are dysregulated in cancer by mutations that cause uncontrolled kinase activity. Tumours that harbour such mutations can be addicted to the activity of a single protein kinase, and kinase inhibitors have recently become a successful class of cancer therapeutic.
Despite rapid progress in the field of “Protein Kinases and Cancer”, opportunities remain for further developments that would transform our understanding of cancer and its treatment. For example, most research is focused on a small subset of human kinases and the biological functions of many cancer-relevant kinases have yet to be explored. This needs to be corrected if we are to fully exploit the potential of protein kinases in cancer therapy. A second example is the trend in drug discovery programmes towards developing approaches to overcome resistance to current therapeutics, such as allosteric kinase inhibitors. This innovative approach takes advantage of developments in our understanding of the structural mechanisms of kinase regulation.
We aim to stimulate discussion by bringing together expert opinion and new science from across the field in a Special Issue of Cancers. We welcome submissions that cover any relevant topic, including protein kinases and non-oncogene addiction; non-canonical protein kinases; protein kinase structure and dynamics; mechanisms of dysregulation in cancer; small molecule inhibitors of protein kinases; allostery in protein kinases; the future of protein kinase therapeutics.Prof. Richard Bayliss
Dr. Sharon Yeoh
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.