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Cancers 2019, 11(4), 523; https://doi.org/10.3390/cancers11040523

Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis

1
Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014 Oulu, Finland
2
Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany
*
Author to whom correspondence should be addressed.
Those authors contributed equally to this work.
Received: 10 February 2019 / Revised: 30 March 2019 / Accepted: 8 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Protein Kinases and Cancers)
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Abstract

The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells. View Full-Text
Keywords: upstream stimulatory factor 2 (USF2); cyclin-dependent kinase-5 (CDK5); CRISPR-Cas9; phosphorylation; proliferation; migration upstream stimulatory factor 2 (USF2); cyclin-dependent kinase-5 (CDK5); CRISPR-Cas9; phosphorylation; proliferation; migration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chi, T.F.; Horbach, T.; Götz, C.; Kietzmann, T.; Dimova, E.Y. Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis. Cancers 2019, 11, 523.

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