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Cancers
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Orthopedic Oncology: Surgical Innovations in 2022
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Orthopedic Oncology: Surgical Innovations in 2022

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5677

Special Issue Editor

Prof. Dr. Michiel A. J. van de Sande

E-Mail Website1 Website2
Guest Editor
1. Department of Pediatric Orthopedic Oncology, Prionces Maxima Center for pediatric Cancer, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands
2. Department of Orthopedic Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Interests: bone and soft tissue sarcomas; pediatric orthopedics; surgical treatment; limb reconstruction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Sarcoma treatment and research focuses mainly on a cure, but at present, 50–60% of patients will still face a metastatic and/or progressive disease within 5 years after diagnosis. Surgical treatment remains the mainstay of treatment with curative intent, not only aiming to improve the chances of survival but also to improve or maintain a high quality of life and limb function. This Issue focuses on the treatment of bone and soft tissue tumors and highlights both improvements in surgical margin optimalization and perfecting functional reconstructions. We aim to include innovative new reconstructions as well as long-term outcomes of classic limb salvage surgery.

You may choose our Joint Special Issue in Current Oncology.

Prof. Dr. Michiel A. J. van de Sande
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological reconstruction
  • joint reconstruction
  • limb salvage
  • surgical margins
  • computer-assisted surgery
  • near infrared fluorescent surgery

Published Papers (2 papers)

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Research

15 pages, 11651 KiB  
Article
Soft Tissue Reconstruction of the Posterior Trunk after Tumor Excision: A Surgical Algorithm
by Marco Innocenti, Francesco Mori, Francesca Alice Pedrini, Luca Salmaso, Andrea Gennaro and Paolo Sassu
Cancers 2023, 15(4), 1214; https://doi.org/10.3390/cancers15041214 - 14 Feb 2023
Viewed by 2895
Abstract
Background: The posterior trunk has been considered a challenging area to reconstruct following soft tissue tumor excision because of the shortage of local donor sites. The advent of innovative procedures such as perforator flaps has radically changed this perspective and offered a new [...] Read more.
Background: The posterior trunk has been considered a challenging area to reconstruct following soft tissue tumor excision because of the shortage of local donor sites. The advent of innovative procedures such as perforator flaps has radically changed this perspective and offered a new approach to the problem. Methods: Upon a review of the literature and the personal experiences of the senior author, an algorithm is developed according to the most updated procedure, combined with more conventional options that maintain a role in decision-making. Results: The upper back latissimus dorsi and trapezium flap are still the most reliable approaches, while perforator flaps based either on the circumflex scapular arteries or the transverse cervical artery represent a more refined option. In the middle third, few indications remain for the reverse latissimus dorsi, while the gold standard is represented by local perforator flaps based on the posterior intercostal system. In the lower back, conventional VY advancement flaps are still a safe and effective option in the sacral area, and perforator flaps based on posterior intercostal arteries, lumbar arteries and superior gluteal arteries are the first choice in most cases. Conclusions: Using perforator flaps significantly improved soft tissue reconstruction in the posterior trunk. Full article
(This article belongs to the Special Issue Orthopedic Oncology: Surgical Innovations in 2022)
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12 pages, 1304 KiB  
Article
One-Stage Synovectomies Result in Improved Short-Term Outcomes Compared to Two-Stage Synovectomies of Diffuse-Type Tenosynovial Giant Cell Tumor (D-TGCT) of the Knee: A Multicenter, Retrospective, Cohort Study
by Geert Spierenburg, Floortje G. M. Verspoor, Jay S. Wunder, Anthony M. Griffin, Peter C. Ferguson, Matthew T. Houdek, David M. King, Richard Boyle, Robert Lor Randall, Steven W. Thorpe, Jacob I. Priester, Erik J. Geiger, Lizz van der Heijden, Nicholas M. Bernthal, Bart H. W. B. Schreuder, Hans Gelderblom and Michiel A. J. van de Sande
Cancers 2023, 15(3), 941; https://doi.org/10.3390/cancers15030941 - 02 Feb 2023
Cited by 1 | Viewed by 1863
Abstract
Diffuse-type tenosynovial giant cell tumors’ (D-TGCTs) intra- and extra-articular expansion about the knee often necessitates an anterior and posterior surgical approach to facilitate an extensive synovectomy. There is no consensus on whether two-sided synovectomies should be performed in one or two stages. This [...] Read more.
Diffuse-type tenosynovial giant cell tumors’ (D-TGCTs) intra- and extra-articular expansion about the knee often necessitates an anterior and posterior surgical approach to facilitate an extensive synovectomy. There is no consensus on whether two-sided synovectomies should be performed in one or two stages. This retrospective study included 191 D-TGCT patients from nine sarcoma centers worldwide to compare the postoperative short-term outcomes between both treatments. Secondary outcomes were rates of radiological progression and subsequent treatments. Between 2000 and 2020, 117 patients underwent one-stage and 74 patients underwent two-stage synovectomies. The maximum range of motion achieved within one year postoperatively was similar (flexion 123–120°, p = 0.109; extension 0°, p = 0.093). Patients undergoing two-stage synovectomies stayed longer in the hospital (6 vs. 4 days, p < 0.0001). Complications occurred more often after two-stage synovectomies, although this was not statistically different (36% vs. 24%, p = 0.095). Patients treated with two-stage synovectomies exhibited more radiological progression and required subsequent treatments more often than patients treated with one-stage synovectomies (52% vs. 37%, p = 0.036) (54% vs. 34%, p = 0.007). In conclusion, D-TGCT of the knee requiring two-side synovectomies should be treated by one-stage synovectomies if feasible, since patients achieve a similar range of motion, do not have more complications, but stay for a shorter time in the hospital. Full article
(This article belongs to the Special Issue Orthopedic Oncology: Surgical Innovations in 2022)
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