The Impact of Iron Metabolism in Cancer

Dear Colleagues, 

Iron is an essential element for the human body. However, excess iron is known to cause some kinds of cancer such as malignant mesothelioma, renal cancer, and ovarian cancer. Excess-free iron induces oxidative stress, which explains the carcinogenesis and acquisition of more malignant potential. The stemness ability of cancer is also known to be closely related with iron metabolism. Interestingly, both over oxidative stress and iron depletion induce cell death such as ferroptosis and apoptosis. This is controversial, making it more suitable for cancer therapy. Furthermore, immune cells and cancer-associated fibroblast are also affected by iron metabolism the same as cancer cells. However, the detailed mechanism and therapeutic approach remain unclear. Thus, this Special Issue aims to reveal the impact of iron metabolism in cancer and tumor, helping to conquer cancer.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: iron metabolism in cancer and tumor microenvironment, iron-related carcinogenesis and progress of malignant potential, iron control cancer therapy (such as iron chelator and ferroptosis inducer), and cancer therapy targeting mitochondria.

We look forward to receiving your contributions. 

Dr. Toshiaki Ohara
Dr. Meera Nanjundan
Guest Editors

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