Pluripotent Stem Cell Applications in Neurological Disease Modeling, Drug Screening, and Regenerative Medicine
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 9607
Special Issue Editors
Interests: embryonic stem cells; induced pluripotent stem cells; developmental biology; disease modeling; neurodegenerative diseases; neurodevelopmental diseases; 2D and 3D cellular models; organoids; co-culture cellular systems; drug screening; personalized medicine; cellular replacement therapy and regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Interests: embryonic stem cells; induced pluripotent stem cells; developmental biology; disease modeling; neurodegenerative diseases; neurodevelopmental diseases; 2D and 3D cellular models; organoids; co-culture cellular systems; drug screening; personalized medicine; cellular replacement therapy and regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A major challenge in human neurodevelopmental and neurodegenerative diseases is the understanding of the detailed mechanisms responsible for the clinical features. In fact, the lack of access to the affected tissue has limited the study of the molecular and cell biological aspects of the pathogenesis of such disorders. The discovery that human pluripotent stem cells (PSCs) can be differentiated into virtually any neural cell type and tissue has opened a new field of investigation in human brain developmental biology and disease. Over the last decade, human PSCs (including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)) have emerged as a valuable and powerful material for the study of neurodevelopmental and neurodegenerative diseases. In addition to disease modeling, the main areas of applications for PSCs are drug discovery and regenerative medicine. Indeed, PSCs could also be of great interest in evaluating the efficacy and toxicity of many compounds in drug discovery. Finally, the use of PSC-derived cells in clinical trials has also increased tremendously, as these cells have shown promising therapeutic effects in animal models.
This Research Topic on “Pluripotent Stem Cell Applications in Neurological Disease Modeling, Drug Screening, and Regenerative Medicine” considers original research articles, review articles, commentaries, and perspectives from all areas of brain research, stem cell biology, and organoid research. This includes but is not limited to 2D and 3D cellular models derived from PSCs for disease modeling, developmental biology, drug screening, toxicity testing, tissue engineering approaches, mathematical models, and tissue regeneration. Co-culture cellular systems including neural cells with other cell types will also be considered for publication in this topic.
Prof. Dr. Anis Feki
Dr. Hibaoui Youssef
Guest Editors
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Keywords
- embryonic stem cells
- induced pluripotent stem cells
- developmental biology
- disease modeling
- neurodegenerative diseases
- neurodevelopmental diseases
- neuropsychiatric diseases
- 2D and 3D cellular models
- organoids
- co-culture cellular systems
- drug screening
- personalized medicine
- cellular replacement therapy and regenerative medicine
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