SERS-Based Sensors: Design and Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: closed (10 May 2018) | Viewed by 33676

Special Issue Editors


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Guest Editor
Professor of Chemical Engineering, Bioengineering, Chemistry & Chemical Biology, Head of Research and Innovation, University Mohamed VI Polytechnic, Lot 660 – Hay Moulay Rachid, 43150 Benguerir, Morocco
Interests: nanomaterials; biomaterials; supramolecular engineering; self-assembly; drug delivery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA
Interests: biomaterials; cryogels; drug delivery; tissue engineering; cancer immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Surface Enhanced Raman Scattering (SERS) spectroscopy is a powerful and well-established analytical method for sensing and ultra-detection (down to a single molecule). Several novel strategies for the design, fabrication, and implementation of SERS-based sensors for applications in life sciences and medicine have emerged in recent years. This Special Issue of Biosensors will focus on: (a) specific nanoscale design and fabrication criteria for SERS-based sensors, (b) the effects of shape, size, periodicity, and chemical composition on signal enhancement, (c) chemical/physical modification to impart sensor specificity/selectivity, (d) biocompatibility, (e) in-vitro and in-vivo sensing in life sciences and medicine, and (f) theranostics (diagnostic imaging and targeted therapy) using SERS-active nanomaterials.

We encourage original contributions or reviews of recent literature in any of these areas.

Prof. Dr. Hicham Fenniri
Assist. Prof. Dr. Sidi M. Bencherif
Guest Editors

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Published Papers (2 papers)

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Review

25 pages, 3315 KiB  
Review
In Vitro and In Vivo SERS Biosensing for Disease Diagnosis
by T. Joshua Moore, Amber S. Moody, Taylor D. Payne, Grace M. Sarabia, Alyssa R. Daniel and Bhavya Sharma
Biosensors 2018, 8(2), 46; https://doi.org/10.3390/bios8020046 - 11 May 2018
Cited by 124 | Viewed by 15320
Abstract
For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the [...] Read more.
For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light. This results in enhancement of the Raman scattering signal, which allows for the detection of low concentration analytes, giving rise to the use of SERS as a diagnostic tool for disease. Here, we present a review of recent developments in the field of in vivo and in vitro SERS biosensing for a range of disease states including neurological disease, diabetes, cardiovascular disease, cancer, and viral disease. Full article
(This article belongs to the Special Issue SERS-Based Sensors: Design and Biomedical Applications)
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5627 KiB  
Review
Review on SERS of Bacteria
by Pamela A. Mosier-Boss
Biosensors 2017, 7(4), 51; https://doi.org/10.3390/bios7040051 - 13 Nov 2017
Cited by 113 | Viewed by 16934
Abstract
Surface enhanced Raman spectroscopy (SERS) has been widely used for chemical detection. Moreover, the inherent richness of the spectral data has made SERS attractive for use in detecting biological materials, including bacteria. This review discusses methods that have been used to obtain SERS [...] Read more.
Surface enhanced Raman spectroscopy (SERS) has been widely used for chemical detection. Moreover, the inherent richness of the spectral data has made SERS attractive for use in detecting biological materials, including bacteria. This review discusses methods that have been used to obtain SERS spectra of bacteria. The kinds of SERS substrates employed to obtain SERS spectra are discussed as well as how bacteria interact with silver and gold nanoparticles. The roll of capping agents on Ag/Au NPs in obtaining SERS spectra is examined as well as the interpretation of the spectral data. Full article
(This article belongs to the Special Issue SERS-Based Sensors: Design and Biomedical Applications)
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