Two-Dimensional Nanomaterials for (Bio)sensing Application

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 812

Special Issue Editor

Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
Interests: nanomaterials; biosensors; electrochemical sensors; SERS sensors; microneedle-based biosensors
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Special Issue Information

Dear Colleagues,

The family of two-dimensional (2D) materials is diverse, including substances such as graphene, transition metal sulfides, and black phosphorus, all of which exhibit high specific surface areas, outstanding carrier mobilities, and tunable band structures. Furthermore, the influence of quantum confinement on electronic and optical properties is also common to most 2D materials.

Over the past two decades, research on 2D materials has attracted a large number of academics in the scientific community, including synthetic chemists and materials scientists, with research advancements in numerous areas, such as supercapacitors, batteries, (photo)catalysis, electrocatalysis, and photovoltaics and so on. In the field of sensors, 2D materials have played a crucial role in dramatically reducing the detection limits of environmental pollutants and harmful residues in food. In biosensing applications, they enable the identification of extremely low levels of biomarkers during the early stages of illness.

This Special Issue aims to compile the latest advancements in 2D material-based sensor technologies. Original research articles, short communications, and reviews are all welcome.

Dr. Jian Ju
Guest Editor

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Keywords

  • two-dimensional nanomaterials
  • synthesis
  • optoelectronics
  • sensors
  • biosensors
  • optical sensing
  • electrochemical sensing
  • environmental pollutant detection
  • food analysis
  • biomarker detection

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Published Papers (1 paper)

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Research

12 pages, 2100 KiB  
Article
Detection of IgG Antibodies Against COVID-19 N-Protein by Hybrid Graphene–Nanorod Sensor
by R. V. A. Boaventura, C. L. Pereira, C. Junqueira, K. B. Gonçalves, N. P. Rezende, I. A. Borges, R. C. Barcelos, F. B. Oréfice, F. F. Bagno, F. G. Fonseca, A. Corrêa, Jr., L. S. Gomes and R. G. Lacerda
Biosensors 2025, 15(3), 164; https://doi.org/10.3390/bios15030164 - 4 Mar 2025
Viewed by 699
Abstract
The COVID-19 pandemic highlighted the global necessity to develop fast, affordable, and user-friendly diagnostic alternatives. Alongside recognized tests such as ELISA, nanotechnologies have since been explored for direct and indirect diagnosis of SARS-CoV-2, the etiological agent of COVID-19. Accordingly, in this work, we [...] Read more.
The COVID-19 pandemic highlighted the global necessity to develop fast, affordable, and user-friendly diagnostic alternatives. Alongside recognized tests such as ELISA, nanotechnologies have since been explored for direct and indirect diagnosis of SARS-CoV-2, the etiological agent of COVID-19. Accordingly, in this work, we report a method to detect anti-SARS-CoV-2 antibodies based on graphene-based field-effect transistors (GFETs), using a nanostructured platform of graphene with added gold nanorods (GNRs) and a specific viral protein. To detect anti-N-protein IgG antibodies for COVID-19 in human sera, gold nanorods were functionalized with the nucleocapsid (N) protein of SARS-CoV-2, and subsequently deposited onto graphene devices. Our test results demonstrate that the sensor is highly sensitive and can detect antibody concentrations as low as 100 pg/mL. Using the sensor to test human sera that were previously diagnosed with ELISA showed a 90% accuracy rate compared to the ELISA results, with the test completed in under 15 min. Integrating graphene and nanorods eliminates the need for a blocker, simplifying sensor fabrication. This hybrid sensor holds robust potential to serve as a simple and efficient point-of-care platform. Full article
(This article belongs to the Special Issue Two-Dimensional Nanomaterials for (Bio)sensing Application)
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