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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomarkers and Molecular Basis of Psychiatry

edited by

Massimo Tusconi

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5796 | Submission Open

Keywords: mental health; bipolar disorders; mood; anxiety; psychosis; schizophrenia; biomarkers

(This special issue belongs to the Section Biological Factors)

Molecular and Cellular Mechanisms in Anti-Thrombosis

edited by

Joen-Rong Sheu

and

Thanasekaran Jayakumar

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5664 | Submission Open

Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms

(This special issue belongs to the Section Molecular Medicine)

Structural Biology of Protein

edited by

Nabanita Saikia

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5629 | Submission Open

Keywords: structural characterization; protein structure– function paradigm; biophysical techniques; computational methods; conformational dynamics; drug discovery; protein– protein interactions

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction

edited by

Jianli Dong

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4962 | Submission Open

Keywords: laboratory genetics and genomics; genetic and genomic biomarkers; diagnostic; prognostic; predictive; companion diagnosis; targeted therapy; nucleic acid

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Signalling Pathways in Tumorigenesis and Tumor Suppression

edited by

Kiyoshi Ohtani

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4822 | Submission Open

Keywords: E2F; RB; p53; cancer; tumor suppression

(This special issue belongs to the Section Biological Factors)

New Insights into Forensic Molecular Genetics

edited by

Erin K. Hanson

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4688 | Submission Open

Keywords: forensic; DNA; RNA; protein; mtDNA; epigenetics; microbiome

(This special issue belongs to the Section Molecular Genetics)

Heterocyclic Compounds as Novel Anti-Cancer Agents and Their Mechanisms of Action

edited by Chandra Mishra and

Dnyaneshwar N. Garad

submission deadline 28 Feb 2026 | 2 articles | Viewed by 4041 | Submission Open

Keywords: heterocyclic compounds; anticancer; synthetic; natural

(This special issue belongs to the Section Molecular Medicine)

Advancing Molecular Regulation in Brain Injury Research: Mechanisms, Diagnosis, and Rehabilitation

edited by Guanglin Zhang and

Pavan Thapak

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3902 | Submission Open

Keywords: brain injury; biomarkers; neurodegeneration; neuroplasticity; neuroimaging; microbial dysbiosis; gut– brain axis; cognitive rehabilitation

(This special issue belongs to the Section Molecular Biology)

Glutamate and Glutamate Receptors in Health and Diseases, Second Edition

edited by

Jolanta H. Kotlińska

and

Marta Marszalek-Grabska

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3651 | Submission Open

Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration

(This special issue belongs to the Section Molecular Biology)

Biomarkers in Metabolic Diseases, 2nd Edition

edited by

Anna Tylki-Szymańska

and

Patryk Lipiński

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2837 | Submission Open

Keywords: metabolic disorders; inborn errors of metabolism; surrogate biomarkers; biochemical markers; diagnostic markers; newborn screening; molecular analyses; metabolomics; disease progression; treatment efficacy

(This special issue belongs to the Section Molecular Biomarkers)

Polyphosphate (PolyP) in Health and Disease

edited by

Félix A. Ruiz

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2517 | Submission Open

Keywords: polyphosphate; polyP; biomarker and therapeutic target

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Tumor Genomics and Liquid Biopsy in Cancer Biology

edited by

Milena Urbini

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2381 | Submission Open

Keywords: circulating tumor DNA (ctDNA); circulating tumor cells (CTCs); exosomes and extracellular vesicles; circulating free RNAs and microRNAs; tumor heterogeneity; mechanisms of metastasis; tumor clonal evolution; drug resistance; tumor microenvironment; multi-omics integration

(This special issue belongs to the Section Molecular Biology)

Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition

edited by

Michele Scuruchi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2103 | Submission Open

Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2089 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione; carbonic anhydrase; etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Single-Molecule Protein Electronics

edited by

Stuart Lindsay

and Bintian Zhang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2019 | Submission Open

Keywords: protein electronics; molecular electronics; single-molecule conductance; protein detection; protein sensing; label-free detection; conductance gating in proteins; electron transport mechanisms in proteins; coherence and dephasing in proteins; role of water in protein conductance; extended electronic states in proteins; hopping conductance in proteins; long-range hopping in proteins; electrode– protein interfaces; charge injection barriers at protein– electrode interfaces; proteins as electronic devices; protein assemblies as electronic devices; DNA electronics; electron transport in DNA; DNA– electrode interfaces; charge injection at a DNA– electrode interface; barrier to charge injection at a DNA– electrode interface

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanism and Detection of SARS-CoV-2

edited by

Zaki A. Sherif

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1945 | Submission Open

Keywords: SARS-CoV-2 spike protein; ACE2 receptor; viral pathogenesis; host-viral protein interactions; molecular diagnostics; RNA virus replication; immune response; viral structural proteins; pathobiology; RT-PCR detection

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Age-Related Macular Degeneration: From Pathogenesis to Therapeutic Strategies

edited by

Serena Fragiotta

, Pier Luigi Grenga and Chiara Ciancimino

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1733 | Submission Open

Keywords: age-related macular degeneration; vascular endothelial growth factor (VEGF); inflammation; neurodegeneration; single-nucleotide polymorphisms (SNP)

(This special issue belongs to the Section Molecular Biology)

Advances in the Pathology of Prostate Cancer: 2nd Edition

edited by

Piwen Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1140 | Submission Open

Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy

(This special issue belongs to the Section Chemical Biology)

Cellular and Molecular Mechanisms in Cardiorenal Syndrome

edited by

Rosemary Wangensteen

, María Carmen Ruiz Fuentes and Maria José Espigares Huete

submission deadline 28 Feb 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure

(This special issue belongs to the Section Molecular Biology)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 28 Feb 2026 | 2 articles | Viewed by 954 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 28 Feb 2026 | 1 articles | Viewed by 759 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Chemical Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 28 Feb 2026 | 1 articles | Viewed by 714 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

Molecular and Cellular Mechanisms of Aortic Diseases

edited by Maria Giovanna Scioli

submission deadline 28 Feb 2026 | 1 articles | Viewed by 502 | Submission Open

Keywords: aortic aneurysms; acute aortic syndromes; aortic dissection; intramural haematoma; penetrating atherosclerotic ulcer; traumatic aortic injury; pseudoaneurysm; aortic rupture; atherosclerotic; inflammatory affections; Marfan syndrome; congenital abnormalities; aortic diseases

(This special issue belongs to the Section Molecular Biology)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 28 Feb 2026 | 1 articles | Viewed by 404 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Exploring Novel Molecular Pathways and Emerging Treatments for Neuromuscular Disorders

edited by

Arturo Lopez-Castel

submission deadline 28 Feb 2026 | Viewed by 368 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 28 Feb 2026 | Viewed by 260 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 28 Feb 2026 | Viewed by 246 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biology)

Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics

edited by

Tong-You Wei

submission deadline 28 Feb 2026 | Viewed by 206 | Submission Open

Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 28 Feb 2026 | Viewed by 166 | Submission Open

Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis

Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches, 2nd Edition

edited by Alice Romagnoli,

Stefano Motta

and

Jesmina Rexha

submission deadline 28 Feb 2026 | Viewed by 161 | Submission Open

Keywords: protein structure and dynamics; protein– protein interactions; point mutations; molecular biology; molecular modeling; molecular dynamics; biochemistry; bioinformatics; protein– ligand interaction; protein– nucleic acid interaction; protein conformational changes

(This special issue belongs to the Section Chemical Biology)

Membrane Clusters in Health and Neurodegenerative Disease

edited by Tayuan Chang and Catherine C. Y. Chang

submission deadline 28 Feb 2026 | Viewed by 138 | Submission Open

Keywords: membrane cluster; membrane lipids; membrane proteins; caveolin; lipid rafts; phospholipid; cholesterol; sphingolipids; cholesteryl esters

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 28 Feb 2026 | Viewed by 137 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Novel Insights and Applications of Pluripotent Stem Cells

edited by

Huseyin Sumer

and Ben Rollo

submission deadline 28 Feb 2026 | Viewed by 130 | Submission Open

Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery

(This special issue belongs to the Section Cellular Biochemistry)

VDAC1 as a Hub Protein–Modulation of VDAC1-Mediated Prograde Cell Death, Metabolism, Inflammation and Immunity via Interacting Proteins, Metabolites and Small Molecules

edited by Jay H. Chung and

Vito De Pinto

submission deadline 28 Feb 2026 | Viewed by 130 | Submission Open

Keywords: apoptosis; binding sites; ferroptosis; inflammation; metabolism; mitochondria; oxidative strass; pyroptosis; small molecules; VDAC

(This special issue belongs to the Section Cellular Biochemistry)

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 28 Feb 2026 | Viewed by 125 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases

edited by Ann Christin Brorsson

submission deadline 28 Feb 2026 | Viewed by 122 | Submission Open

Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism

Functional Analysis of Genes Related to DNA Damage

edited by Ryan P. Barnes and Amy M. Whitaker

submission deadline 28 Feb 2026 | Viewed by 121 | Submission Open

Keywords: DNA damage; DNA repair; genome stability; DNA replication stress

(This special issue belongs to the Section Molecular Biology)

Modern Studies of Nucleic Acid Dynamics

edited by

Gary A. Meints

submission deadline 28 Feb 2026 | Viewed by 117 | Submission Open

Keywords: nucleic acid dynamics; DNA; RNA; nucleic acid energetics; dynamics of biomolecular recognition; timescales and magnitudes of dynamics

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 28 Feb 2026 | Viewed by 115 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood– brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

The N-Methyl-D-Aspartate (NMDA) Receptor: From Pathophysiology to Clinical Significance

edited by

Motohiro Okada

submission deadline 28 Feb 2026 | Viewed by 111 | Submission Open

Keywords: L-glutamate; D-serine; ionotropic glutamate receptors; psychiatric disorders; neurodegeneration; synaptic plasticity; epilepsy; pathophysiology; signaling

Biomarkers and Therapeutic Approaches in Melanoma: New Omics-Strategies

edited by

Italia Falcone

Fabio Valenti

and

Stefano Giuliani

submission deadline 28 Feb 2026 | Viewed by 106 | Submission Open

Keywords: melanoma; biomarkers; omics; precision oncology; drug resistance

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Genetics of Parasitic Protozoa

edited by

Paştiu Anamaria Ioana

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health

(This special issue belongs to the Section Molecular Genetics)

Photosynthetic Adaptation and Photoprotection in Plants

edited by

Roland Valcke

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: pigment– protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies

edited by

Suzanne M. De La Monte

submission deadline 14 Mar 2026 | Viewed by 75 | Submission Open

Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases

edited by Kristina Seiffert-Sinha and Animesh A. Sinha

submission deadline 15 Mar 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Mar 2026 | Viewed by 62 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition

edited by

Marina Piscopo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1575 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 20 Mar 2026 | Viewed by 179 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health

edited by

Giacomo Fais

and

Giorgia Sarais

submission deadline 20 Mar 2026 | Viewed by 134 | Submission Open

Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems

The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics

edited by Gregory F. Oxenkrug

submission deadline 27 Mar 2026 | Viewed by 79 | Submission Open

Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation

(This special issue belongs to the Section Biological Factors)

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